Advanced Histological Stainings at ICS

ICS is proud to offer new capabilities for histological examinations, the Masson’s trichrome and the Russell-Movat pentachrome stains. 

Both these stains are excellent means for visualizing collagen deposits (fibroses), but with the Movat’s pentachrome stain one can also differentiate elastic fibres, muscle, mucin, and fibrin.  For detailed histological examinations or high quality images for publication, consider these stains to improve your understanding and impress your colleagues. 

 

Left picture: Masson trichrone staining of a heart with massive fibrosis (in blue)

Right picture: Movat Pentachrome Phamini modification: collagen is stained by light green

Model Creation Services

Charles River Europe has joined forces with PHENOMIN-ICS, a scientific leader in functional genomics, to deliver a complete solution for mouse and rat model creation.

Neuromuscular Phenotyping

ICS is proud to offer novel assays for assessment of neuromuscular and muscular defects as part of our phenotyping. 

Mouse Reaching and Grasping (MoRaG) assay as well as automated gait (DigiGait) analysis now complement our existing grip strength, rotorod, and beam walking assays.  Along with  isolated muscular strength assays that are coming soon, we provide excellent capabilities to assess neuromuscular and muscular defects in your animals.  

European Consortium 'CanPathPro' started !

New platform for predictive modelling of cancer signaling started ! 

PHENOMIN-ICS is involved in the CanPathPro project with respect to the generation of genetically modified mouse models.

CanPathPro brings together the complex molecular data from the "omics" technologies (genomics, transcriptomics and proteomics) that explain the basis of cancers and also reflects their heterogeneity for most, and the mathematical tools of systems biology to visualize and predict signaling pathways for new preclinical, clinical and biotechnology applications. Read more.

Direct blastocyst genotyping

Validate your cryopreserved line by direct blastocyst genotyping

Direct blastocyst genotyping is now available for your lines at PHENOMIN-ICS. Using this method instead of conventional post-implantation genotyping protocols leads to significant reductions in animal welfare concerns, processing time, technical requirements, and cost. For details, see the publication we coauthored in Transgenic Res (F. Scavizzi et al, 2015).

Comprehensive analysis of ageing phenotypes

In concert with the research community and the International Mouse Phenotyping Consortium (IMPC), INFRAFRONTIER is currently developing new pilot platforms and services for the research on ageing and age-related diseases. Read more.