ICS line text

This website uses cookies to ensure you get the best experience on our website. Learn more

About ICS

Follow ICS

A resource of targeted mutant mouse lines for 5,061 genes.

Birling MC, Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bürger A, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Hérault Y, de Angelis MH, Jiang ST, Justice MJ, Kasparek P, King RE, Kühn R, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Pavlovic G, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Schick J, Seavitt JR, Sedlacek R, Seisenberger C, Seong JK, Skarnes WC, Sorg T, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wattenhofer-Donzé M, Wells S, Wiles MV, Willis BJ, Wood JA, Wurst W, Xu Y, Teboul L, Murray SA
Nat Genet 2021 Apr;53(4):416-419

View on PubMed

Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society

Dierssen M.a,b,c · Herault Y.d · Helguera P.e · Martínez de Lagran M.a,c · Vazquez A.b · Christian B.f · Carmona-Iragui M.g,h · Wiseman F.i · Mobley W.j · Fisher E.M.C.k · Brault V.d · Esbensen A.l · Jacola L.M.m · Potier M.C.n · Hamlett E.D.o · Abbeduto L.p · del Hoyo Soriano L.p · Busciglio J.q · Iulita M.F.r · Crispino J.s · Malinge S.t · Barone E.u · Perluigi M.u · Costanzo F.v · Delabar J.M.n · Bartesaghi R.w · Dekker A.D.x · De Deyn P.x,y · Fortea Ormaechea J.g,h · Shaw P.A.z · Haydar T.F.z · Sherman S.L.A · Strydom A.B · Bhattacharyya A.f
Molecular Syndromology 2021 MAY 2021

Characterization of the spontaneous degenerative mitral valve disease in FVB mice.

Ayme-Dietrich E, Da Silva S, Bouabout GA, Arnoux A, Guyonnet J, Becker G, Monassier L
Plos One 2021 ;16(9):e0257022

View on PubMed

Droplet digital PCR or quantitative PCR for in-depth genomic and functional validation of genetically altered rodents.

Lindner L, Cayrou P, Rosahl TW, Zhou HH, Birling MC, Herault Y, Pavlovic G
Methods 2021 Jul;191():107-119

View on PubMed

Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome.

Brault V, Nguyen TL, Flores-Gutiérrez J, Iacono G, Birling MC, Lalanne V, Meziane H, Manousopoulou A, Pavlovic G, Lindner L, Selloum M, Sorg T, Yu E, Garbis SD, Hérault Y
Plos Genet 2021 Sep;17(9):e1009777

View on PubMed

HDAC inhibitor ameliorates behavioral deficits in Mecp2(308/y) mouse model of Rett syndrome.

Lebrun N, Delépine C, Selloum M, Meziane H, Nectoux J, Herault Y, Bienvenu T
Brain Res 2021 Dec 1;1772():147670

View on PubMed

High Resolution Episcopic Microscopy for Qualitative and Quantitative Data in Phenotyping Altered Embryos and Adult Mice Using the New "Histo3D" System.

Wendling O, Hentsch D, Jacobs H, Lemercier N, Taubert S, Pertuy F, Vonesch JL, Sorg T, Di Michele M, Le Cam L, Rosahl T, Carballo-Jane E, Liu M, Mu J, Mark M, Herault Y
Biomedicines 2021 Jul 1;9(7):

View on PubMed

Importing genetically altered animals: ensuring quality.

Birling MC, Fray MD, Kasparek P, Kopkanova J, Massimi M, Matteoni R, Montoliu L, Nutter LMJ, Raspa M, Rozman J, Ryder EJ, Scavizzi F, Voikar V, Wells S, Pavlovic G, Teboul L
Mamm Genome 2021 Sep 18

View on PubMed

INFRAFRONTIER quality principles in systemic phenotyping.

Ehlich H, Cater HL, Flenniken AM, Goncalves Da Cruz I, Mura AM, Ntafis V, Raess M, Selloum M, Stoeger C, Suchanova S, Vuolteenaho R, Brown SDM, Hérault Y, Hinttala R, Hrabě de Angelis M, Kollias G, Kontoyiannis DL, Malissen B, McKerlie C, Sedláček R, Wells SE, Zarubica A, Rozman J, Sorg T
Mamm Genome 2021 Jul 30

View on PubMed

Integrative approach to interpret DYRK1A variants, leading to a frequent neurodevelopmental disorder.

Courraud J, Chater-Diehl E, Durand B, Vincent M, Del Mar Muniz Moreno M, Boujelbene I, Drouot N, Genschik L, Schaefer E, Nizon M, Gerard B, Abramowicz M, Cogné B, Bronicki L, Burglen L, Barth M, Charles P, Colin E, Coubes C, David A, Delobel B, Demurger F, Passemard S, Denommé AS, Faivre L, Feger C, Fradin M, Francannet C, Genevieve D, Goldenberg A, Guerrot AM, Isidor B, Johannesen KM, Keren B, Kibæk M, Kuentz P, Mathieu-Dramard M, Demeer B, Metreau J, Steensbjerre Møller R, Moutton S, Pasquier L, Pilekær Sørensen K, Perrin L, Renaud M, Saugier P, Rio M, Svane J, Thevenon J, Tran Mau Them F, Tronhjem CE, Vitobello A, Layet V, Auvin S, Khachnaoui K, Birling MC, Drunat S, Bayat A, Dubourg C, El Chehadeh S, Fagerberg C, Mignot C, Guipponi M, Bienvenu T, Herault Y, Thompson J, Willems M, Mandel JL, Weksberg R, Piton A
Genet Med 2021 Aug 3

View on PubMed

Introduction to mammalian genome special issue: the microbiome in human health and disease.

Pavlovic G, Seong JK, Weinstock GM
Mamm Genome 2021 Aug;32(4):205

View on PubMed

Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity.

Wang XL, Kooijman S, Gao Y, Tzeplaeff L, Cosquer B, Milanova I, Wolff SEC, Korpel N, Champy MF, Petit-Demoulière B, Goncalves Da Cruz I, Sorg-Guss T, Rensen PCN, Cassel JC, Kalsbeek A, Boutillier AL, Yi CX
Mol Psychiatry 2021 May 28

View on PubMed

Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models.

Duchon A, Del Mar Muniz Moreno M, Martin Lorenzo S, Silva de Souza MP, Chevalier C, Nalesso V, Meziane H, Loureiro de Sousa P, Noblet V, Armspach JP, Brault V, Herault Y
Hum Mol Genet 2021 May 28;30(9):771-788

View on PubMed

Pathogenesis of Anorectal Malformations in Retinoic Acid Receptor Knockout Mice Studied by HREM.

Mark M, Teletin M, Wendling O, Vonesch JL, Féret B, Hérault Y, Ghyselinck NB
Biomedicines 2021 Jun 28;9(7):

View on PubMed

Reliable and robust droplet digital PCR (ddPCR) and RT-ddPCR protocols for mouse studies.

Lindner L, Cayrou P, Jacquot S, Birling MC, Herault Y, Pavlovic G
Methods 2021 Jul;191():95-106

View on PubMed

SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2.

Niewiadomska-Cimicka A, Doussau F, Perot JB, Roux MJ, Keime C, Hache A, Piguet F, Novati A, Weber C, Yalcin B, Meziane H, Champy MF, Grandgirard E, Karam A, Messaddeq N, Eisenmann A, Brouillet E, Nguyen HHP, Flament J, Isope P, Trottier Y
J Neurosci 2021 Jun 2;41(22):4910-4936

View on PubMed

Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models.

Martin Lorenzo S, Nalesso V, Chevalier C, Birling MC, Herault Y
Mol Autism 2021 Jan 13;12(1):1

View on PubMed

search icon