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2023Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in miceKim Reid, Eileen G Daniels, Goutham Vasam, Rashmi Kamble, Georges E Janssens, Iman M Hu, Alexander E Green, Riekelt H Houtkooper, Keir J Menzies |
Androgen receptor coordinates muscle metabolic and contractile functionsKamar Ghaibour, Mélanie Schuh, Sirine Souali-Crespo, Céline Chambon, Anouk Charlot, Joe Rizk, Daniela Rovito, Anna-Isavella Rerra, Qingshuang Cai, Nadia Messaddeq, Joffrey Zoll, Delphine Duteil & Daniel Metzger |
CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intakeKarl Vivot, Gergö Meszaros, Evanthia Pangou, Zhirong Zhang, Mengdi Qu, Eric Erbs, Gagik Yeghiazaryan, Mar Quiñones, Erwan Grandgirard, Anna Schneider, Etienne Clauss-Creusot, Alexandre Charlet, Maya Faour, Claire Martin, Fedor Berditchevski, Izabela Sumara, Serge Luquet, Peter Kloppenburg, Ruben Nogueiras, Romeo Ricci |
Altered X-chromosome inactivation predisposes to autoimmune manifestations in miceChristophe Huret, Antoine David, Myriame Mohamed, Nicolas Valentin, Frédéric Charlotte, Michele Goodhardt, Claire Rougeulle and Céline Morey
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2022CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a Nonredundant Role in Lupus-Like Disease DevelopmentJohn Tchen, Quentin Simon, Léa Chapart, Christophe Pellefigues, Hajime Karasuyama, Kensuke Miyake, Ulrich Blank, Marc Benhamou, Eric Daugas, Nicolas Charles |
The Shank3Venus/Venus knock in mouse enables isoform-specific functional studies of Shank3aNathalie Bouquier, Sophie Sakkaki, Fabrice Raynaud, Anne-Laure Hemonnot-Girard, Vincent Seube, Vincent Compan, Federica Bertaso, Julie Perroy, Enora Moutin |
Differential impact of ubiquitous and muscle dynamin 2 isoforms in muscle physiology and centronuclear myopathyRaquel Gómez-Oca, Evelina Edelweiss, Sarah Djeddi, Mathias Gerbier, Xènia Massana-Muñoz, Mustapha Oulad-Abdelghani, Corinne Crucifix, Coralie Spiegelhalter, Nadia Messaddeq, Pierre Poussin-Courmontagne, Pascale Koebel, Belinda S. Cowling and Jocelyn Laporte |
The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapsesCharlotte Calvet, Thibault Peineau, Najate Benamer, Maxence Cornille , Andrea Lelli, Baptiste Plion, Ghizlène Lahlou, Julia Fanchette, Sylvie Nouaille, Jacques Boutet de Monvel, Amrit Estivalet, Philippe Jean, Vincent Michel , Martin Sachse, Nicolas Michalski, Paul Avan, Christine Petit , Didier Dulon, Saaid Safieddine |
2021A medullary centre for lapping in miceBowen Dempsey, Selvee Sungeelee, Phillip Bokiniec, Zoubida Chettouh, Séverine Diem, Sandra Autran, Evan R Harrell, James F A Poulet, Carmen Birchmeier , Harry Carey, Auguste Genovesio, Simon McMullan, Christo Goridis, Gilles Fortin, Jean-François Brunet |
Pain behavior in SCN9A (Nav1.7) and SCN10A (Nav1.8) mutant rodent models.Xue Y, Chidiac C, Herault Y, Gaveriaux-Ruff C |
Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.Deshpande D, Agarwal N, Fleming T, Gaveriaux-Ruff C, Klose CSN, Tappe-Theodor A, Kuner R, Nawroth P |
2020Characteristic dental pattern with hypodontia and short roots in Fraser syndrome.Kunz F, Kayserili H, Midro A, de Silva D, Basnayake S, Guven Y, Borys J, Schanze D, Stellzig-Eisenhauer A, Bloch-Zupan A, Zenker M |
Evidence that corticofugal propagation of ALS pathology is not mediated by prion-like mechanismJelena Scekic-Zahirovic , Mathieu Fischer , Geoffrey Stuart-Lopez , Thibaut Burg , Johan Gilet , Sylvie Dirrig-Grosch , Christine Marques , Marie-Christine Birling , Pascal Kessler , Caroline Rouaux
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Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPNCamélia Benlabiod, Maira da Costa Cacemiro, Audrey Nédélec, Valérie Edmond, Delphine Muller, Philippe Rameau, Laure Touchard, Patrick Gonin, Stefan N Constantinescu, Hana Raslova, Jean-Luc Villeval, William Vainchenker, Isabelle Plo, Caroline Marty
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H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse musclesEdwige Belotti, Nicolas Lacoste, Thomas Simonet, Christophe Papin, Kiran Padmanabhan, Isabella Scionti, Yann-Gaël Gangloff, Lorrie Ramos, Defne Dalkara, Ali Hamiche, Stefan Dimitrov, Laurent Schaeffer |
High Levels of Frataxin Overexpression Lead to Mitochondrial and Cardiac Toxicity in Mouse ModelsBrahim Belbellaa, Laurence Reutenauer, Nadia Messaddeq, Laurent Monassier, HélènePuccio |
Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 SignatureOlivier Gouin, Claire Barbieux, Florent Leturcq, Mathilde Bonnet des Claustres, Evgeniya Petrova, Alain Hovnanian |
Targeting Morphine-Responsive Neurons: Generation of a Knock-In Mouse Line Expressing Cre Recombinase from the Mu-Opioid Receptor Gene LocusBailly J, Del Rossi N, Runtz L, Li JJ, Park D, Scherrer G, Tanti A, Birling MC, Darcq E, Kieffer BL |
Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an alpha5-selective GABA(A) inverse agonist.Duchon A, Gruart A, Albac C, Delatour B, Zorrilla de San Martin J, Delgado-Garcia JM, Herault Y, Potier MC |
Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking.Da Costa R, Bordessoules M, Guilleman M, Carmignac V, Lhussiez V, Courot H, Bataille A, Chlémaire A, Bruno C, Fauque P, Thauvin C, Faivre L, Duplomb L. |
2019BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylationMaxime Sartori,Tiago Mendes,Shruti Desai,Alessia Lasorsa, Adrien Herledan,Nicolas Malmanche,Petra Mäkinen,Mikael Marttinen,Idir Malki,Julien Chapuis,Amandine Flaig,Anaïs-Camille Vreulx,Marion Ciancia,Philippe Amouyel,Florence Leroux,Benoit Déprez,François-Xavier Cantrelle,Damien Maréchal,Laurent Pradier,Mikko Hiltunen,Isabelle Landrieu,Devrim Kilinc,Yann Herault,Jocelyn Laporte, Jean-Charles Lambert
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Disrupting the IL-36 and IL-23/IL-17 loop underlies the efficacy of calcipotriol and corticosteroid therapy for psoriasis.Germán B, Wei R, Hener P, Martins C5, Ye T, Gottwick C, Yang J, Seneschal J, Boniface K, Li M. |
STIM1 over-activation generates a multi-systemic phenotype affecting the skeletal muscle, spleen, eye, skin, bones and immune system in mice.Silva-Rojas R, Treves S, Jacobs H, Kessler P, Messaddeq N, Laporte J, Böhm J. |
Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL. |
Mitochondrial defect in muscle precedes neuromuscular junction degeneration and motor neuron death in CHCHD10S59L/+ mouse.Genin EC, Madji Hounoum B, Bannwarth S, Fragaki K, Lacas-Gervais S, Mauri-Crouzet A, Lespinasse F, Neveu J, Ropert B, Augé G, Cochaud C, Lefebvre-Omar C, Bigou S, Chiot A, Mochel F, Boillée S, Lobsiger CS, Bohl D, Ricci JE, Paquis-Flucklinger V. |
Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models.Souchet B, Duchon A, Gu Y, Dairou J, Chevalier C, Daubigney F, Nalesso V, Créau N, Yu Y, Janel N, Herault Y, Delabar JM. |
2018The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen InfectionHideki Hara, Sergey S Seregin , Dahai Yang, Koichi Fukase , Mathias Chamaillard, Emad S Alnemri , Naohiro Inohara, Grace Y Chen , Gabriel Núñez
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Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent mannerKim YH, Noh JR, Hwang JH, Kim KS, Choi DH, Kim JH, Moon SJ, Choi JH, Hérault Y, Lee TG, Choi HS, Lee CH |
Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammationPariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW. |
Single Intramuscular Injection of AAV-shRNA Reduces DNM2 and Prevents Myotubular Myopathy in MiceHichem Tasfaout, Valentina M. Lionello, Christine Kretz, Pascale Koebel, Nadia Messaddeq, Deborah Bitz, Jocelyn Laporte. |
2017A molecular mechanism for the topographic alignment of convergent neural maps.Savier E1, Eglen SJ2,3, Bathélémy A1, Perraut M1, Pfrieger FW1, Lemke G4, Reber M1,3. |
Col4a1 mutation generates vascular abnormalities correlated with neuronal damage in a mouse model of HANAC syndromeAlix Trouillet, Henri Lorach, Elisabeth Dubus, Brahim El Mathari, Ivana Ivkovic, Julie Dégardin, Manuel Simonutti, Michel Paques, Xavier Guillonneau, Florian Sennlaub, José-Alain Sahel, Pierre Ronco, Emmanuelle Plaisier, Serge Picaud |
Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice.Arefin TM, Mechling AE, Meirsman AC, Bienert T, Hübner NS, Lee HL, Ben Hamida S, Ehrlich A, Roquet D, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA. |
Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction.Libé-Philippot B, Michel V, Boutet de Monvel J, Le Gal S, Dupont T, Avan P, Métin C, Michalski N, Petit C.
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Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson’s disease motor symptoms without neuronal degeneration in adult mice.Isingrini E, Guinaudie C, Perret LC, Rainer Q, Moquin L, Gratton A, Giros B. |
VMAT2-mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation.Xu Y, Lu Y, Xu P, Mangieri LR, Isingrini E, Xu Y, Giros B and Tong Q. |
RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis.Han YH, Kim HJ, Na H, Nam MW, Kim JY, Kim JS, Koo SH, Lee MO. |
Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, Bolte S, Bernard V, Vigneault E, Goutagny R, Ahnert-Hilger G, Giros B, Daumas S, Williams S, El Mestikawy S. |
Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processingAliza T. Ehrlich, Meriem Semache, Julie Bailly, Stefan Wojcik, Tanzil M. Arefin, Christine Colley, Christian Le Gouill, Florence Gross,Viktoriya Lukasheva, Mireille Hogue, Emmanuel Darcq, Laura-Adela Harsan, Michel Bouvier, Brigitte L. Kieffer. |
Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression.Bonet C, Luciani F, Ottavi JF, Leclerc J, Jouenne FM, Boncompagni M, Bille K, Hofman V, Bossis G, Marco de Donatis G, Strub T, Cheli Y, Ohanna M, Luciano F, Marchetti S, Rocchi S, Birling MC, Avril MF, Poulalhon N, Luc T, Bertolotto C.
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Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA. |
2016The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic FidelityYohan Roulland, Khalid Ouararhni, Mladen Naidenov, Lorrie Ramos, Muhammad Shuaib, Sajad Hussain Syed, Imtiaz Nizar Lone, Ramachandran Boopathi, Emeline Fontaine, Gabor Papai, Hiroaki Tachiwana, Thierry Gautier, Dimitrios Skoufias, Kiran Padmanabhan, Jan Bednar, Hitoshi Kurumizaka, Patrick Schultz, Dimitar Angelov, Ali Hamiche, Stefan Dimitrov |
The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Hérault Y, Guillou F, Bourc'his D. |
Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist.
Meirsman AC1, Le Merrer J2, Pellissier LP3, Diaz J4, Clesse D5, Kieffer BL6, Becker JA2. |
Selective genetic disruption of dopaminergic, serotoninergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behavior.Isingrini E, Perret L, Rainer Q, Sagueby S, Moquin L, Gratton A, Giros B. |
GPR88 in A2AR Neurons Enhances Anxiety-Like BehaviorsAura Carole Meirsman, Anne Robé, Alban de Kerchove d’Exaerde, and Brigitte Lina Kieffer
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Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain.McDonald T, Liang HA, Sanoja R, Gotter AL, Kuduk SD, Coleman PJ, Smith KM, Winrow CJ, Renger JJ.
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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for DrugDevelopment in Down Syndrome.Duchon A, Herault Y. |
The Cannabinoid Receptor 2 Protects Against Alcoholic Liver Disease Via a Macrophage Autophagy-Dependent Pathway.Denaës T, Lodder J, Chobert MN, Ruiz I, Pawlotsky JM, Lotersztajn S, Teixeira-Clerc F. |
Rev-erbα in the brain is essential for circadian food entrainment.Delezie J, Dumont S, Sandu C, Reibel S, Pevet P, Challet E. |
Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable FoodPauline Charbogne, Olivier Gardon, Elena Martín-García, Helen L. Keyworth, Aya Matsui,
Anna E. Mechling, Thomas Bienert, Taufiq Nasseef, Anne Robé, Luc Moquin, Emmanuel Darcq,
Sami Ben Hamida, Patricia Robledo, Audrey Matifas, Katia Befort, Claire Gavériaux-Ruff,
Laura-Adela Harsan, Dominik von Elverfeldt, Jurgen Hennig, Alain Gratton, Ian Kitchen,
Alexis Bailey, Veronica A. Alvarez, Rafael Maldonado, and Brigitte L. Kieffer |
Resilience against chronic stress is mediated by noradrenergic regulation of dopamine neurons.Isingrini E, Perret L, Rainer Q, Amilhon B, Guma E, Tanti A, Martin G, Robinson J, Moquin L, Marti F, Mechawar N, Williams S, Gratton A, Giros B. |
Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice.Diaz-Castroverde S, Gómez-Hernández A, Fernández S, García-Gómez G, Di Scala M, González-Aseguinolaza G, Fernández-Millán E, González-Rodríguez Á, García-Bravo M, Chambon P, Álvarez C, Perdomo L, Beneit N, Escribano O, Benito M. |
A suppressor locus for MODY3-diabetes.Garcia-Gonzalez MA, Carette C, Bagattin A, Chiral M, Makinistoglu MP, Garbay S, Prévost G, Madaras C, Hérault Y, Leibovici M, Pontoglio M. |
2015A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.Huet T, Laverny G, Ciesielski F, Molnár F, Ramamoorthy TG, Belorusova AY, Antony P, Potier N, Metzger D, Moras D, Rochel N. |
Nociceptin/Orphanin-FQ Modulation of Learning and Memory.Abdel-Mouttalib O. |
Early embryonic-like cells are induced by downregulating replication-dependent chromatin assemblyTakashi Ishiuchi, Rocio Enriquez-Gasca, Eiji Mizutani, Ana Bošković, Celine Ziegler-Birling,
Diego Rodriguez-Terrones, Teruhiko Wakayama, Juan M Vaquerizas & Maria-Elena Torres-Padilla |
Generation and Validation of miR-142 Knock Out MiceAmit Shrestha,Gianni Carraro,Elie El Agha,Regina Mukhametshina,Cho-Ming Chao,Albert Rizvanov, Guillermo Barreto, Saverio Bellusci
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Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularizationNicolas Rama 1, Alexandre Dubrac 2, Thomas Mathivet 3, Róisín-Ana Ní Chárthaigh 1, Gael Genet 2, Brunella Cristofaro 3, Laurence Pibouin-Fragner 3, Le Ma 4, Anne Eichmann 5, Alain Chédotal 1 |
The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO2Pierre-Louis Ruffault, Fabien D’Autrévaux, John A Hayes, Marc Nomaksteinsky,
Sandra Autran, Tomoyuki Fujiyama, Mikio Hoshino, Martin Hägglund
Ole Kiehn, Jean-François Brunet, Gilles Fortin, Christo Goridis |
2014Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndromeSahún I, Marechal D, Pereira PL, Nalesso V, Gruart A, Garcia JM, Antonarakis
SE, Dierssen M, Herault Y
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LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity.Tajan M, Batut A, Cadoudal T, Deleruyelle S, Le Gonidec S, Saint Laurent C, Vomscheid M, Wanecq E, Tréguer K, De Rocca Serra-Nédélec A, Vinel C, Marques MA, Pozzo J, Kunduzova O, Salles JP, Tauber M, Raynal P, Cavé H, Edouard T, Valet P, Yart A. |
Proteomic survey reveals altered energetic patterns and metabolic failure prior to retinal degeneration.Griciuc A, Roux MJ, Merl J, Giangrande A, Hauck SM, Aron L, Ueffing M. |
Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.Weinl C, Wasylyk C, Garcia Garrido M, Sothilingam V, Beck SC, Riehle H, Stritt C, Roux MJ, Seeliger MW, Wasylyk B, Nordheim A |
Domains of genome-wide gene expression dysregulation in Down's syndrome.Letourneau A, Santoni FA, Bonilla X, Sailani MR, Gonzalez D, Kind J, Chevalier
C, Thurman R, Sandstrom RS, Hibaoui Y, Garieri M, Popadin K, Falconnet E,
Gagnebin M, Gehrig C, Vannier A, Guipponi M, Farinelli L, Robyr D, Migliavacca E,
Borel C, Deutsch S, Feki A, Stamatoyannopoulos JA, Herault Y, van Steensel B,
Guigo R, Antonarakis SE
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Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits.De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, Bäckhed F, Mithieux G. |
Intestinal gluconeogenesis is crucial to maintain a physiological fasting glycemia in the absence of hepatic glucose production in mice.Penhoat A, Fayard L, Stefanutti A, Mithieux G, Rajas F |
Dendrite Self-Avoidance Requires Cell-Autonomous Slit/Robo Signaling in Cerebellar Purkinje CellsDaniel A. Gibson, Stephen Tymanskyj, Rachel C. Yuan, Haiwen C. Leung, Julie L. Lefebvre, Joshua R., Sanes, Alain Chédotal and Le Ma |
Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder.Segura-Puimedon M, Sahún I, Velot E, Dubus P, Borralleras C, Rodrigues AJ,
Valero MC, Valverde O, Sousa N, Herault Y, Dierssen M, Pérez-Jurado LA, Campuzano
V.
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Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humansDe la Torre R, De Sola S, Pons M, Duchon A, de Lagran MM, Farré M, Fitó M,
Benejam B, Langohr K, Rodriguez J, Pujadas M, Bizot JC, Cuenca A, Janel N,
Catuara S, Covas MI, Blehaut H, Herault Y, Delabar JM, Dierssen M.
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The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.Labialle S1, Marty V1, Bortolin-Cavaillé ML1, Hoareau-Osman M1, Pradère JP2, Valet P2, Martin PG3, Cavaillé J4. |
Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actionsAdlanmerini M, Solinhac R, Abot A, Fabre A, Raymond-Letron I, Guihot AL, Boudou F, Sautier L, Vessières E, Kim SH, Lière P, Fontaine C, Krust A, Chambon P, Katzenellenbogen JA, Gourdy P, Shaul PW, Henrion D, Arnal JF, Lenfant F. |
NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation.Béchade C, Colasse S, Diana MA, Rouault M, Bessis A. |
The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acidsOlivia Tort, Sebastián Tanco, Cecilia Rocha, Ivan Bièche, Cecilia Seixas, Christophe Bosc, Annie Andrieux, Marie-Jo Moutin, Francesc Xavier Avilés, Julia Lorenzo and Carsten Janke |
Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.Rachdi L, Kariyawasam D, Aïello V, Herault Y, Janel N, Delabar JM, Polak M,
Scharfmann R.
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The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease.Niemann A, Huber N, Wagner KM, Somandin C, Horn M, Lebrun-Julien F, Angst B, Pereira JA, Halfter H, Welzl H, Feltri ML, Wrabetz L, Young P, Wessig C, Toyka KV, Suter U. |
2013Robo3-driven axon midline crossing conditions functional maturation of a large commissural synapse.Michalski N, Babai N, Renier N, Perkel DJ, Chédotal A, Schneggenburger R. |
Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRsMukherji A, Kobiita A, Ye T, Chambon P |
JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.Hasan S, Lacout C, Marty C, Cuingnet M, Solary E, Vainchenker W, Villeval JL. |
Climbing fiber input shapes reciprocity of purkinje cell firing.Badura A, Schonewille M, Voges K, Galliano E, Renier N, Gao Z, Witter L, Hoebeek FE, Chédotal A, De Zeeuw CI. |
Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease.Nemazanyy I, Blaauw B, Paolini C, Caillaud C, Protasi F, Mueller A, Proikas-Cezanne T, Russell RC, Guan KL, Nishino I, Sandri M, Pende M, Panasyuk G. |
Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.Ben M'Barek K1, Pla P, Orvoen S, Benstaali C, Godin JD, Gardier AM, Saudou F, David DJ, Humbert S. |
Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout MiceRaphaël Weibel, David Reiss, Laurie Karchewski, Olivier Gardon, Audrey Matifas, Dominique Filliol, Jérôme A. J. Becker, John N. Wood, Brigitte L. Kieffer, and Claire Gaveriaux-Ruff |
Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis.Kabashi E, El Oussini H, Bercier V, Gros-Louis F, Valdmanis PN, McDearmid J, Mejier IA, Dion PA, Dupre N, Hollinger D, Sinniger J, Dirrig-Grosch S, Camu W, Meininger V, Loeffler JP, René F, Drapeau P, Rouleau GA, Dupuis L. |
Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass CK. |
Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.Sun Z1, Feng D1, Fang B1, Mullican SE1, You SH1, Lim HW1, Everett LJ1, Nabel CS1, Li Y1, Selvakumaran V1, Won KJ1, Lazar MA2. |
p53-PGC-1a Pathway Mediates Oxidative Mitochondrial Damage and Cardiomyocyte Necrosis Induced by Monoamine Oxidase-A Upregulation: Role in Chronic Left Ventricular Dysfunction in MiceChristelle Villeneuve,1,2,* Ce´ line Guilbeau-Frugier,1,2,* Pierre Sicard,1,2 Olivier Lairez,1,2 Catherine Ordener,1,2 Thibaut Duparc,1,2 Damien De Paulis,3,4 Bettina Couderc,2 Odile Spreux-Varoquaux,5 Florence Tortosa,1,2 Anne Garnier,6 Claude Knauf,1,2 Philippe Valet,1,2 Elisabetta Borchi,7 Chiara Nediani,7 Abdallah Gharib,3,4 Michel Ovize,3,4 Marie-Bernadette Delisle,1,2 Angelo Parini,1,2 and Jeanne Mialet-Perez1,2 |
Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome.Koutsopoulos OS, Kretz C, Weller CM, Roux A, Mojzisova H, Böhm J, Koch C, Toussaint A, Heckel E, Stemkens D, Ter Horst SA, Thibault C, Koch M, Mehdi SQ, Bijlsma EK, Mandel JL, Vermot J, Laporte J. |
Hepatic glucose sensing is required to preserve β cell glucose competence.Seyer P, Vallois D, Poitry-Yamate C, Schütz F, Metref S, Tarussio D, Maechler P, Staels B, Lanz B, Grueter R, Decaris J, Turner S, da Costa A, Preitner F, Minehira K, Foretz M, Thorens B. |
Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin.Diaz SL, Narboux-Nême N, Trowbridge S, Scotto-Lomassese S, Kleine Borgmann FB, Jessberger S, Giros B, Maroteaux L, Deneris E, Gaspar P. |
Postnatal growth defects in mice with constitutive depletion of central serotonin.Narboux-Nême N, Angenard G, Mosienko V, Klempin F, Pitychoutis PM, Deneris E, Bader M, Giros B, Alenina N, Gaspar P.
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The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye.Berry DC, Jacobs H, Marwarha G, Gely-Pernot A, O'Byrne SM, DeSantis D, Klopfenstein M, Feret B, Dennefeld C, Blaner WS, Croniger CM, Mark M, Noy N, Ghyselinck NB. |
Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening David Adams, Richard Baldock, Shoumo Bhattacharya, Andrew J. Copp, Mary Dickinson, Nicholas D. E. Greene, Mark Henkelman, Monica Justice, Timothy Mohun, Stephen A. Murray, Erwin Pauws, Michael Raess, Janet Rossant,Tom Weaver, and David West.
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2012DYRK1A: a master regulatory protein controlling brain growth.Guedj F, Pereira PL, Najas S, Barallobre MJ, Chabert C, Souchet B, Sebrie C, Verney C, Herault Y, Arbones M, Delabar JM. |
The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.Raveau M, Lignon JM, Nalesso V, Duchon A, Groner Y, Sharp AJ, Dembele D, Brault V, Hérault Y. |
The in vivo Down syndrome genomic library in mouse.Herault Y, Duchon A, Velot E, Maréchal D, Brault V. |
The nuclear receptor REV-ERBalpha-/- is required for the daily balance of carbohydrate and lipid metabolismJulien Delezie, Stéphanie Dumont, Hugues Dardente, Hugues Oudart, Aline Gréchez-Cassiau, Paul Klosen, Michèle Teboul, Franck Delaunay, Paul Pévet and Etienne Challet |
An epigenetic silencing pathway controlling T helper 2 cell lineage commitmentAllan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, Roche D, Maison C, Quivy JP, Almouzni G, Amigorena S. |
LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: implications for Charcot-Marie-Tooth disease.Somandin C, Gerber D, Pereira JA, Horn M, Suter U. |
Primary T-tubule and autophagy defects in the phosphoinositide phosphatase Jumpy/MTMR14 knockout mice muscle.Hnia K, Kretz C, Amoasii L, Böhm J, Liu X, Messaddeq N, Qu CK, Laporte J. |
Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.Amoasii L, Bertazzi DL, Tronchère H, Hnia K, Chicanne G, Rinaldi B, Cowling BS, Ferry A, Klaholz B, Payrastre B, Laporte J, Friant S. |
Control of ground-state pluripotency by allelic regulation of Nanog.Miyanari Y, Torres-Padilla ME. |
Analysis of active chromatin modifications in early mammalian embryos reveals uncoupling of H2A.Z acetylation and H3K36 trimethylation from embryonic genome activation.Bošković A, Bender A, Gall L, Ziegler-Birling C, Beaujean N, Torres-Padilla ME. |
Structural and Functional Concepts in Current Mouse Phenotyping and Archiving FacilitiesKollmus H, Post R, Brielmeier M, Fernández J, Fuchs H, McKerlie C, Montoliu L, Otaegui PJ, Rebelo M, Riedesel H, Ruberte J, Sedlacek R, de Angelis MH, Schughart K. |
BBS-Induced Ciliary Defect Enhances Adipogenesis, Causing Paradoxical Higher-Insulin Sensitivity, Glucose Usage, and decreased Inflammatory responseBSMarion V, Mockel A, De Melo C, Obringer C, Claussmann A, Simon A, Messaddeq N, Durand M, Dupuis L, Loeffer JP, King P, Mutter-schmidt C, Petrovsky N, Stoetzel C, Dollfuss H |
Epilepsy gene LGI1 regulates postnatal developmental remodeling of retinogeniculate synapsesZhou YD, Zhang D, Ozkaynak E, Wang X, Kasper EM, Leguern E, Baulac S, Anderson MP |
Pharmacological modulation of the retinal unfolded protein response in Bardet-Biedl syndrome reduces apoptosis and preserves light detection abilityMockel A, Obringer C, Hakvoort TBM, Seeliger M, Lamers WH, Stoetzel C, Dollfus H, Marion V |
Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cellsHorn M, Baumann R, Pereira JA, Sidiropoulos PN, Somandin C, Welzl H, Stendel C, Lühmann T, Wessig C, Toyka KV, Relvas JB, Senderek J, Suter U |
2011Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereociliaCaberlotto E, Michel V, Foucher I, Bahloul A, Goodyear RJ, Pepermans E, Michalski N, Perfettini I, Alegria-Prévot O, Chardenoux S, Do Cruzeiro M, Hardelin JP, Richardson GP, Avan P, Weil D, Petit C |
Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing.Billon-Galés A, Krust A, Fontaine C, Abot A, Flouriot G, Toutain C, Berges H, Gadeau AP, Lenfant F, Gourdy P, Chambon P, Arnal JF. |
Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone.Börjesson AE, Windahl SH, Lagerquist MK, Engdahl C, Frenkel B, Movérare-Skrtic S, Sjögren K, Kindblom JM, Stubelius A, Islander U, Antal MC, Krust A, Chambon P, Ohlsson C. |
A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.Lebreton A, Lakisic G, Job V, Fritsch L, Tham TN, Camejo A, Matteï PJ, Regnault B, Nahori MA, Cabanes D, Gautreau A, Ait-Si-Ali S, Dessen A, Cossart P, Bierne H. |
Necdin protects embryonic motoneurons from programmed cell deathAebischer J, Sturny R, Andrieu D, Rieusset A, Schaller F, Geib S, Raoul C, Muscatelli F |
Severe Serotonin Depletion after Conditional Deletion of the Vesicular Monoamine Transporter 2 Gene in Serotonin Neurons: Neural and Behavioral ConsequencesNarboux-Nême N, Sagné C, Doly S, Diaz SL, Martin CB, Angenard G, Martres MP, Giros B, Hamon M, Lanfumey L, Gaspar P, Mongeau R. |
Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle.Hnia K, Tronchère H, Tomczak KK, Amoasii L, Schultz P, Beggs AH, Payrastre B, Mandel JL, Laporte J. |
Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progressionBoehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson A, Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F, Dantzer F |
Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomasMutel E, Abdul-Wahed A, Ramamonjisoa N, Stefanutti A, Houberdon I, Cavassila S, Pilleul F, Beuf O, Gautier-Stein A, Penhoat A, Mithieux G, Rajas F |
Prmt2 regulates the lipopolysaccharide-induced responses in lungs and macrophages.Dalloneau E, Pereira PL, Brault V, Nabel EG, Hérault Y. |
Protein-induced satiety is abolished in the absence of intestinal gluconeogenesisPenhoat A, Mutel E, Amigo-Correig M, Pillot B, Stefanutti A, Rajas F, Mithieux G |
Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB.Brault V, Martin B, Costet N, Bizot JC, Hérault Y. |
Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine.Goeldner C, Lutz PE, Darcq E, Halter T, Clesse D, Ouagazzal AM, Kieffer BL. |
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia.Gaveriaux-Ruff C, Nozaki C, Nadal X, Hever XC, Weibel R, Matifas A, Reiss D, Filliol D, Nassar MA, Wood JN, Maldonado R, Kieffer BL. |
Influence of endogenous opioid systems on T lymphocytes as assessed by the knockout of mu, delta and kappa opioid receptors.Karaji AG, Reiss D, Matifas A, Kieffer BL, Gavériaux-Ruff C. |
The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndromeDuchon A, Pothion S, Brault V, Sharp AJ, Tybulewicz VL, Fisher EM, Herault Y. |
Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.Duchon A, Raveau M, Chevalier C, Nalesso V, Sharp AJ, Herault Y. |
2010A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 geneSchaller F, Watrin F, Sturny R, Massacrier A, Szepetowski P, Muscatelli F |
Controlled Somatic and Germline Copy Number Variation in the Mouse ModelYann Hérault, Arnaud Duchon, Damien Maréchal, Matthieu Raveau, Patricia L. Pereira,
Emilie Dalloneau and Véronique Brault |
A centronuclear myopathy-dynamin 2 mutation impairs skeletal muscle structure and function in mice.Durieux AC, Vignaud A, Prudhon B, Viou MT, Beuvin M, Vassilopoulos S, Fraysse B, Ferry A, Lainé J, Romero NB, Guicheney P, Bitoun M. |
Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3.Santenard A, Ziegler-Birling C, Koch M, Tora L, Bannister AJ, Torres-Padilla ME. |
Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shapeEtournay R, Lepelletier L, Boutet de Monvel J, Michel V, Cayet N, Leibovici M, Weil D, Foucher I, Hardelin JP, Petit C |
Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to miceKumar R, Bourbon HM, de Massy B |
Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient miceChabrol E, Navarro V, Provenzano G, Cohen I, Dinocourt C, Rivaud-Péchoux S, Fricker D, Baulac M, Miles R, Leguern E, Baulac S |
Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipidsBahloul A, Michel V, Hardelin JP, Nouaille S, Hoos S, Houdusse A, England P, Petit C |
Jarid2 and PRC2, partners in regulating gene expression.Li G1, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D. |
Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues.Velasco G, Hubé F, Rollin J, Neuillet D, Philippe C, Bouzinba-Segard H, Galvani A, Viegas-Péquignot E, Francastel C. |
Genetic dissection of the function of hindbrain axonal commissures.Renier N, Schonewille M, Giraudet F, Badura A, Tessier-Lavigne M, Avan P, De Zeeuw CI, Chédotal A. |
2009The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol.Billon-Galés A, Fontaine C, Filipe C, Douin-Echinard V, Fouque MJ, Flouriot G, Gourdy P, Lenfant F, Laurell H, Krust A, Chambon P, Arnal JF. |
TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte.Gazdag E, Santenard A, Ziegler-Birling C, Altobelli G, Poch O, Tora L, Torres-Padilla ME. |
T-tubule disorganization and defective excitation-contraction coupling in muscle fibers lacking myotubularin lipid phosphatase.Al-Qusairi L, Weiss N, Toussaint A, Berbey C, Messaddeq N, Kretz C, Sanoudou D, Beggs AH, Allard B, Mandel JL, Laporte J, Jacquemond V, Buj-Bello A. |
2008Effective gene therapy of mice with congenital erythropoietic porphyria is facilitated by a survival advantage of corrected erythroid cellsRobert-Richard E, Moreau-Gaudry F, Lalanne M, Lamrissi-Garcia I, Cario-André M, Guyonnet-Dupérat V, Taine L, Ged C, de Verneuil H |
Erythropoietic porphyrias: animal models and update in gene-based therapiesRichard E, Robert-Richard E, Ged C, Moreau-Gaudry F, de Verneuil H |
Disruption of Krox20–Nab Interaction in the Mouse Leads to Peripheral Neuropathy with Biphasic EvolutionDesmazières A, Decker L, Vallat JM, Charnay P, Gilardi-Hebenstreit P. |
Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERbeta-null mutant.Antal MC, Krust A, Chambon P, Mark M. |
Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: comparison to morphine.Reiss D, Wichmann J, Tekeshima H, Kieffer BL, Ouagazzal AM. |
Successful gene therapy of mice with congenital erythropoietic porphyriade Verneuil H, Robert-Richard E, Ged C, Mazurier F, Richard E, Moreau-Gaudry F |
2006Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell deathAndrieu D, Meziane H, Marly F, Angelats C, Fernandez PA, Muscatelli F |
A knock-in mouse model of congenital erythropoietic porphyriaGed C, Mendez M, Robert E, Lalanne M, Lamrissi-Garcia I, Costet P, Daniel JY, Dubus P, Mazurier F, Moreau-Gaudry F, de Verneuil H |
Knockin mice expressing fluorescent δ-opioid receptors uncover G protein-coupled receptor dynamics invivoGrégory Scherrer, Petra Tryoen-Tóth, Dominique Filliol, Audrey Matifas, Delphine Laustriat, Yu Q. Cao, Allan I. Basbaum, Andrée Dierich, Jean-Luc Vonesh, Claire Gavériaux-Ruff, and Brigitte L. Kieffer |
2004Tissue-specific and inducible Cre-mediated recombination in the gut epitheliumEl Marjou F., Janssen K.P., Hung-Junn Chang B., Li M., Hindie V., Chan L., Louvard D., Chambon P., Metzger D., Robine S |
Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model.Helmlinger D, Abou-Sleymane G, Yvert G, Rousseau S, Weber C, Trottier Y, Mandel JL, Devys D. |
2002Progressive retinal degeneration and dysfunction in R6 Huntington's disease mice.Helmlinger D, Yvert G, Picaud S, Merienne K, Sahel J, Mandel JL, Devys D. |
The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice.Buj-Bello A, Laugel V, Messaddeq N, Zahreddine H, Laporte J, Pellissier JF, Mandel JL. |
