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About ICS

A new mouse model of ARX dup24 recapitulates the patients' behavioral and fine motor alterations.

Dubos A(1)(2)(3)(4), Meziane H(4), Iacono G(5), Curie A(6), Riet F(4), Martin C(7), Loaec N(8), Birling MC(4), Selloum M(4), Normand E(7)(9), Pavlovic G(4), Sorg T(4), Stunnenberg HG(5), Chelly J(1)(2)(3)(10), Humeau Y(7), Friocourt G(8), Herault Y(1)(2)(3)(4).
Hum Mol Genet 2018 Jun 15;27(12):2138-2153

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A Population Study of Common Ocular Abnormalities in C57BL/6N rd8 Mice.

Moore BA(1), Roux MJ(2)(3)(4)(5), Sebbag L(1), Cooper A(1), Edwards SG(1), Leonard BC(1), Imai DM(6), Griffey S(6), Bower L(7), Clary D(7), Lloyd KCK(7)(8), Herault Y(2)(3)(4)(5)(9), Thomasy SM(10)(11), Murphy CJ(10)(11), Moshiri A(11).
Invest Ophthalmol Vis Sci 2018 May 1;59(6):2252-2261

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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.

Nguyen TL(1)(2)(3)(4)(5), Duchon A(1)(2)(3)(4), Manousopoulou A(6), Loaec N(5), Villiers B(5), Pani G(1)(2)(3)(4), Karatas M(7)(8), Mechling AE(8), Harsan LA(7)(8), Limanton E(9), Bazureau JP(9), Carreaux F(9), Garbis SD(10), Meijer L(11), Herault Y(12)(2)(3)(4).
Dis Model Mech 2018 Sep 27;11(9):pii: dmm035634

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Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Moore BA(1), Leonard BC(#)(2), Sebbag L(#)(1), Edwards SG(1), Cooper A(1), Imai DM(3), Straiton E(4), Santos L(4), Reilly C(3), Griffey SM(3), Bower L(5), Clary D(5), Mason J(6), Roux MJ(7)(8)(9)(10)(11), Meziane H(7)(8)(9)(10)(11), Herault Y(7)(8)(9)(10)(11); International Mouse Phenotyping Consortium, McKerlie C(12)(13), Flenniken AM(12)(14), Nutter LMJ(12)(13), Berberovic Z(12)(14), Owen C(12)(14), Newbigging S(12)(14), Adissu H(12)(14), Eskandarian M(12)(14), Hsu CW(15), Kalaga S(15), Udensi U(15), Asomugha C(15), Bohat R(16), Gallegos JJ(16), Seavitt JR(16), Heaney JD(16), Beaudet AL(16), Dickinson ME(15)(16), Justice MJ(12)(13)(16), Philip V(17), Kumar V(17), Svenson KL(17), Braun RE(17), Wells S(4), Cater H(4), Stewart M(4), Clementson-Mobbs S(4), Joynson R(4), Gao X(18), Suzuki T(19), Wakana S(19), Smedley D(20), Seong JK(21), Tocchini-Valentini G(22), Moore M(23), Fletcher C(24), Karp N(25), Ramirez-Solis R(25), White JK(17)(25), de Angelis MH(26), Wurst W(26), Thomasy SM(2)(27), Flicek P(6), Parkinson H(6), Brown SDM(4), Meehan TF(6), Nishina PM(17), Murray SA(17), Krebs MP(17), Mallon AM(4), Lloyd KCK(5), Murphy CJ(2)(27), Moshiri A(27).
Commun Biol 2018 Dec 21;1():236

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Identification of genetic elements in metabolism by high-throughput mouse phenotyping.

Rozman J(1)(2), Rathkolb B(1)(2)(3), Oestereicher MA(1), Schutt C(1), Ravindranath AC(2)(4), Leuchtenberger S(1), Sharma S(2)(5), Kistler M(1), Willershauser M(6)(7)(8), Brommage R(1), Meehan TF(9), Mason J(9), Haselimashhadi H(9); IMPC Consortium, Hough T(10), Mallon AM(10), Wells S(10), Santos L(10), Lelliott CJ(11), White JK(11)(12), Sorg T(13)(14)(15)(16)(17), Champy MF(13)(14)(15)(16)(17), Bower LR(18), Reynolds CL(19), Flenniken AM(20)(21)(22), Murray SA(12), Nutter LMJ(20)(21), Svenson KL(12), West D(23), Tocchini-Valentini GP(24), Beaudet AL(20)(21), Bosch F(25), Braun RB(12), Dobbie MS(26), Gao X(27), Herault Y(13)(14)(15)(16)(17), Moshiri A(28), Moore BA(29), Kent Lloyd KC(18), McKerlie C(20)(21), Masuya H(30), Tanaka N(30), Flicek P(9), Parkinson HE(9), Sedlacek R(31), Seong JK(32), Wang CL(33), Moore M(34), Brown SD(10), Tschop MH(2)(35)(36), Wurst W(37)(38)(39)(40), Klingenspor M(6)(7)(8), Wolf E(2)(3), Beckers J(1)(2)(41), Machicao F(42), Peter A(2)(42)(43), Staiger H(2)(43)(44), Haring HU(2)(42)(43), Grallert H(2)(5)(45), Campillos M(2)(4), Maier H(1), Fuchs H(1), Gailus-Durner V(1), Werner T(46), Hrabe de Angelis M(47)(48)(49).
Nat Commun 2018 Jan 18;9(1):288

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Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome.

Iacono G(1), Dubos A(2)(3)(4)(5), Meziane H(2), Benevento M(6)(7)(8), Habibi E(1), Mandoli A(1), Riet F(2), Selloum M(2), Feil R(9)(10), Zhou H(1)(7), Kleefstra T(7)(8), Kasri NN(6)(7)(8), van Bokhoven H(6)(7)(8), Herault Y(2)(3)(4)(5), Stunnenberg HG(1).
Nucleic Acids Res 2018 Jun 1;46(10):4950-4965

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Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects.

Miller CO, Yang X, Lu K, Cao J, Herath K, Rosahl TW, Askew R, Pavlovic G, Zhou G, Li C, Akiyama TE
Am J Physiol Endocrinol Metab 2018 Sep 1;315(3):E386-E393

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Nox4 genetic inhibition in experimental hypertension and metabolic syndrome.

Bouabout G(1), Ayme-Dietrich E(2), Jacob H(1), Champy MF(1), Birling MC(1), Pavlovic G(1), Madeira L(2), Fertak LE(1), Petit-Demouliere B(1), Sorg T(1), Herault Y(1), Mudgett J(3), Monassier L(4).
Arch Cardiovasc Dis 2018 Jan;111(1):41-52

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Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse.

Ung DC(1)(2), Iacono G(3), Meziane H(4), Blanchard E(1)(5)(6), Papon MA(1)(2), Selten M(7), van Rhijn JR(7), Montjean R(8)(9)(10)(11), Rucci J(8)(9)(10)(11), Martin S(12), Fleet A(13), Birling MC(4), Marouillat S(1)(2), Roepman R(14)(15), Selloum M(4), Lux A(4), Thepault RA(1)(2), Hamel P(13), Mittal K(16), Vincent JB(16), Dorseuil O(8)(9)(10)(11), Stunnenberg HG(3), Billuart P(8)(9)(10)(11), Nadif Kasri N(7)(14), Herault Y(4)(17)(18)(19)(20), Laumonnier F(1)(2)(6).
Mol Psychiatry 2018 May;23(5):1356-1367

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Synaptic dysfunction in amygdala in intellectual disorder models.

Aincy M(1), Meziane H(2), Herault Y(3), Humeau Y(4).
Prog Neuropsychopharmacol Biol Psychiatry 2018 Jun 8;84(pt B):392-397

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Translating molecular advances in Down syndrome and Fragile X syndrome into therapies.

Faundez V(1), De Toma I(2), Bardoni B(3), Bartesaghi R(4), Nizetic D(5), de la Torre R(6), Cohen Kadosh R(7), Herault Y(8), Dierssen M(9), Potier MC(10); Down Syndrome and Other Genetic Developmental Disorders ECNP Network.
Eur Neuropsychopharmacol 2018 Jun;28(6):675-690

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