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About ICS

Please mind that the following list is still in progress and non-exhaustive, and that most of our USERS publications are rather classified as ICS publications since some of ICS staff are coauthors.

2024


Altered X-chromosome inactivation predisposes to autoimmunity

Christophe Huret, Léa Ferrayé, Antoine David, Myriame Mohamed, Nicolas Valenti, Frédéric Charlotte, Magali Savignac, Michele Goodhardt,Jean-Charles Guéry And Céline Morey
Scienceadvances 2024;10

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2023


Gdaphen, R pipeline to identify the most important qualitative and quantitative predictor variables from phenotypic data

Maria Del Mar Muñiz Moreno 1 2, Claire Gavériaux-Ruff 3, Yann Herault 4 5
Bmc Bioinformatics 2023;-

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Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse model

Anna Rusu 1, Claire Chevalier 1, Fabrice de Chaumont 2, Valérie Nalesso 1, Véronique Brault 1, Yann Hérault # 1 2, Elodie Ey #1
Frontiers In Behavioral Neuroscience 2023;-

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Altered X-chromosome inactivation predisposes to autoimmune manifestations in mice

Christophe Huret, Antoine David, Myriame Mohamed, Nicolas Valentin, Frédéric Charlotte, Michele Goodhardt, Claire Rougeulle and Céline Morey
Bioorxiv 2023;-

The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton Author links open overlay panel

José Rivera Alvarez 1, Laure Asselin 1, Peggy Tilly 1, Roxane Benoit 1, Claire Batisse 1, Ludovic Richert 2, Julien Batisse 1, Bastien Morlet 1, Florian Levet 3, Noémie Schwaller 1, Yves Mély 2, Marc Ruff 1, Anne-Cécile Reymann 1, Juliette D Godin 4
Cell Reports 2023;-

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Hypoxia-inducible factor 1A inhibition overcomes castration resistance of prostate tumors

Julie Terzic # 1 2 3 4, Mohamed A Abu El Maaty # 1 2 3 4 5, Régis Lutzing 1 2 3 4, Alexandre Vincent 1 2 3 4, Rana El Bizri 1 2 3 4, Matthieu Jung 1 2 3 4, Céline Keime 1 2 3 4, Daniel Metzger 1 2 3 4
Embo Molecular Medicine 2023;-

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Androgen receptor coordinates muscle metabolic and contractile functions

Kamar Ghaibour, Mélanie Schuh, Sirine Souali-Crespo, Céline Chambon, Anouk Charlot, Joe Rizk, Daniela Rovito, Anna-Isavella Rerra, Qingshuang Cai, Nadia Messaddeq, Joffrey Zoll, Delphine Duteil & Daniel Metzger
Journal Of Cachexia, Sarcopenia And Muscle 2023;Aug;14(4)

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CaMK1D signalling in AgRP neurons promotes ghrelin-mediated food intake

Karl Vivot, Gergö Meszaros, Evanthia Pangou, Zhirong Zhang, Mengdi Qu, Eric Erbs, Gagik Yeghiazaryan, Mar Quiñones, Erwan Grandgirard, Anna Schneider, Etienne Clauss-Creusot, Alexandre Charlet, Maya Faour, Claire Martin, Fedor Berditchevski, Izabela Sumara, Serge Luquet, Peter Kloppenburg, Ruben Nogueiras, Romeo Ricci
Nature Metabolism 2023;2023 Jun;5(6):1045-1058

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The HP1α protein is mandatory to repress the circadian clock and its output genes during the 12 h period of transcriptional repression

Nisha Misra 1, Manohar Damara 1, Pierre Chambon 1 2 3
Pnas 2023;-

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Wfs1E864K knock-in mice illuminate the fundamental role of Wfs1 in endocochlear potential production

Elodie M Richard # 1, Emilie Brun # 2, Julia Korchagina 2, Lucie Crouzier 3, Corentin Affortit 2, Stacy Alves 3, Chantal Cazevieille 2, Anne-Laure Mausset-Bonnefont 4, Marc Lenoir 2, Jean-Luc Puel 2, Tangui Maurice 3, Marc Thiry 5, Jing Wang 2, Benjamin Delprat 6 7
Cell Death And Disease 2023;-

CD4+ regulatory T cells lacking Helios and Eos

Katarzyna Polak 1, Patricia Marchal 1, Chiara Taroni 1, Claudine Ebel 2, Peggy Kirstetter 1, Philippe Kastner 3, Susan Chan 4
Biochemical And Biophysical Research Communications 2023;-

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Reducing mitochondrial ribosomal gene expression does not alter metabolic health or lifespan in mice

Kim Reid, Eileen G Daniels, Goutham Vasam, Rashmi Kamble, Georges E Janssens, Iman M Hu, Alexander E Green, Riekelt H Houtkooper, Keir J Menzies
Scientific Reports 2023;2023 May 24;13(1):8391

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2022


The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses

Charlotte Calvet, Thibault Peineau, Najate Benamer, Maxence Cornille , Andrea Lelli, Baptiste Plion, Ghizlène Lahlou, Julia Fanchette, Sylvie Nouaille, Jacques Boutet de Monvel, Amrit Estivalet, Philippe Jean, Vincent Michel , Martin Sachse, Nicolas Michalski, Paul Avan, Christine Petit , Didier Dulon, Saaid Safieddine
Iscience 2022;12

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High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning

Angela M Getz 1, Mathieu Ducros 2, Christelle Breillat 1, Aurélie Lampin-Saint-Amaux 1, Sophie Daburon 1, Urielle François 1, Agata Nowacka 1, Mónica Fernández-Monreal 2, Eric Hosy 1, Frédéric Lanore 1, Hanna L Zieger 1, Matthieu Sainlos 1, Yann Humeau 1, Daniel Choquet 1 2
Science Advances 2022;-

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Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration

Satish Bodakuntla, Xidi Yuan, Mariya Genova, Sudarshan Gadadhar, Sophie Leboucher, Marie-Christine Birling, Dennis Klein, Rudolf Martini, Carsten Janke, Maria M Magiera
Embo 2022;-

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Differential impact of ubiquitous and muscle dynamin 2 isoforms in muscle physiology and centronuclear myopathy

Raquel Gómez-Oca, Evelina Edelweiss, Sarah Djeddi, Mathias Gerbier, Xènia Massana-Muñoz, Mustapha Oulad-Abdelghani, Corinne Crucifix, Coralie Spiegelhalter, Nadia Messaddeq, Pierre Poussin-Courmontagne, Pascale Koebel, Belinda S. Cowling and Jocelyn Laporte
Nature Communications 2022;13

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CT-M8 Mice: A New Mouse Model Demonstrates That Basophils Have a Nonredundant Role in Lupus-Like Disease Development

John Tchen, Quentin Simon, Léa Chapart, Christophe Pellefigues, Hajime Karasuyama, Kensuke Miyake, Ulrich Blank, Marc Benhamou, Eric Daugas, Nicolas Charles
Frontiers In Immunology 2022;13

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The Shank3Venus/Venus knock in mouse enables isoform-specific functional studies of Shank3a

Nathalie Bouquier, Sophie Sakkaki, Fabrice Raynaud, Anne-Laure Hemonnot-Girard, Vincent Seube, Vincent Compan, Federica Bertaso, Julie Perroy, Enora Moutin
Frontiers In Neuroscience 2022; 2022 Dec 8;16:1081010

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Pseudocowpox virus, a novel vector to enhance the therapeutic efficacy of antitumor vaccination

Rodrigo Nalio Ramos 1 2 3, Caroline Tosch 4, Fiorella Kotsias 1, Marie-Christine Claudepierre 4, Doris Schmitt 4, Christelle Remy-Ziller 4, Chantal Hoffmann 4, Marine Ricordel 4, Virginie Nourtier 4, Isabelle Farine 4, Laurence Laruelle 4, Julie Hortelano 4, Clementine Spring-Giusti 4, Christine Sedlik 1, Christophe Le Tourneau 5, Caroline Hoffmann 1 6, Nathalie Silvestre 4, Philippe Erbs 4, Kaidre Bendjama 4, Christine Thioudellet 4, Eric Quemeneur 4, Eliane Piaggio 1, Karola Rittner 4
Clinical And Translatinal Immunology 2022;-

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2021


Pain behavior in SCN9A (Nav1.7) and SCN10A (Nav1.8) mutant rodent models.

Xue Y, Chidiac C, Herault Y, Gaveriaux-Ruff C
Neurosci Lett. 2021;2021 May 14;753:135844. doi: 10.1016/j.neulet.2021.135844.

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A medullary centre for lapping in mice

Bowen Dempsey, Selvee Sungeelee, Phillip Bokiniec, Zoubida Chettouh, Séverine Diem, Sandra Autran, Evan R Harrell, James F A Poulet, Carmen Birchmeier , Harry Carey, Auguste Genovesio, Simon McMullan, Christo Goridis, Gilles Fortin, Jean-François Brunet
Nature Commpunications 2021;2021 Nov 2;12(1):6307

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Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.

Deshpande D, Agarwal N, Fleming T, Gaveriaux-Ruff C, Klose CSN, Tappe-Theodor A, Kuner R, Nawroth P
Nat Commun. 2021;2021 Jan 18;12(1):426. doi: 10.1038/s41467-020-20677-0.

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2020


High Levels of Frataxin Overexpression Lead to Mitochondrial and Cardiac Toxicity in Mouse Models

Brahim Belbellaa, Laurence Reutenauer, Nadia Messaddeq, Laurent Monassier, HélènePuccio
Molecular Therapy Molecular Therapy - Methods & Clinical Development 2020;Volume 19, 11 December 2020, Pages 120-138

Evidence that corticofugal propagation of ALS pathology is not mediated by prion-like mechanism

Jelena Scekic-Zahirovic , Mathieu Fischer , Geoffrey Stuart-Lopez , Thibaut Burg , Johan Gilet , Sylvie Dirrig-Grosch , Christine Marques , Marie-Christine Birling , Pascal Kessler , Caroline Rouaux
Prog Neurobiol 2020;Dec 9;101972.

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Targeting Morphine-Responsive Neurons: Generation of a Knock-In Mouse Line Expressing Cre Recombinase from the Mu-Opioid Receptor Gene Locus

Bailly J, Del Rossi N, Runtz L, Li JJ, Park D, Scherrer G, Tanti A, Birling MC, Darcq E, Kieffer BL
Eneuro 2020;May 29;7(3):ENEURO.0433

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H2A.Z is dispensable for both basal and activated transcription in post-mitotic mouse muscles

Edwige Belotti, Nicolas Lacoste, Thomas Simonet, Christophe Papin, Kiran Padmanabhan, Isabella Scionti, Yann-Gaël Gangloff, Lorrie Ramos, Defne Dalkara, Ali Hamiche, Stefan Dimitrov, Laurent Schaeffer
Nucleic Acids Research 2020;2020 May 21;48(9):4601-4613

Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN

Camélia Benlabiod, Maira da Costa Cacemiro, Audrey Nédélec, Valérie Edmond, Delphine Muller, Philippe Rameau, Laure Touchard, Patrick Gonin, Stefan N Constantinescu, Hana Raslova, Jean-Luc Villeval, William Vainchenker, Isabelle Plo, Caroline Marty
Nature Communications 2020;2020 Sep 28;11(1):4886

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Vps13b is required for acrosome biogenesis through functions in Golgi dynamic and membrane trafficking.

Da Costa R, Bordessoules M, Guilleman M, Carmignac V, Lhussiez V, Courot H, Bataille A, Chlémaire A, Bruno C, Fauque P, Thauvin C, Faivre L, Duplomb L.
Eur J Appl Physiol. 2020;Jun 20. doi: 10.1007/s00421-019-04173-y. [Epub ahead of print]

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Characteristic dental pattern with hypodontia and short roots in Fraser syndrome.

Kunz F, Kayserili H, Midro A, de Silva D, Basnayake S, Guven Y, Borys J, Schanze D, Stellzig-Eisenhauer A, Bloch-Zupan A, Zenker M
Am J Med Genet A 2020;Jul;182(7):1681-1689.

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Long-lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an alpha5-selective GABA(A) inverse agonist.

Duchon A, Gruart A, Albac C, Delatour B, Zorrilla de San Martin J, Delgado-Garcia JM, Herault Y, Potier MC
Br J Pharmacol 2020;Mar;177(5):1106-1118. Epub 2020 Jan 9.

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Transgenic Kallikrein 14 Mice Display Major Hair Shaft Defects Associated with Desmoglein 3 and 4 Degradation, Abnormal Epidermal Differentiation, and IL-36 Signature

Olivier Gouin, Claire Barbieux, Florent Leturcq, Mathilde Bonnet des Claustres, Evgeniya Petrova, Alain Hovnanian
Journal Of Investigative Dermatology 2020;140

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2019


Mitochondrial defect in muscle precedes neuromuscular junction degeneration and motor neuron death in CHCHD10S59L/+ mouse.

Genin EC, Madji Hounoum B, Bannwarth S, Fragaki K, Lacas-Gervais S, Mauri-Crouzet A, Lespinasse F, Neveu J, Ropert B, Augé G, Cochaud C, Lefebvre-Omar C, Bigou S, Chiot A, Mochel F, Boillée S, Lobsiger CS, Bohl D, Ricci JE, Paquis-Flucklinger V.
Acta Neuropathol. 2019;Mar 14. doi: 10.1007/s00401-019-01988-z

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Disrupting the IL-36 and IL-23/IL-17 loop underlies the efficacy of calcipotriol and corticosteroid therapy for psoriasis.

Germán B, Wei R, Hener P, Martins C5, Ye T, Gottwick C, Yang J, Seneschal J, Boniface K, Li M.
Jci Insight 2019;Jan 24;4(2)

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STIM1 over-activation generates a multi-systemic phenotype affecting the skeletal muscle, spleen, eye, skin, bones and immune system in mice.

Silva-Rojas R, Treves S, Jacobs H, Kessler P, Messaddeq N, Laporte J, Böhm J.
Hum Mol Genet. . 2019;May 15;28(10):1579-1593.

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BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

Maxime Sartori,Tiago Mendes,Shruti Desai,Alessia Lasorsa, Adrien Herledan,Nicolas Malmanche,Petra Mäkinen,Mikael Marttinen,Idir Malki,Julien Chapuis,Amandine Flaig,Anaïs-Camille Vreulx,Marion Ciancia,Philippe Amouyel,Florence Leroux,Benoit Déprez,François-Xavier Cantrelle,Damien Maréchal,Laurent Pradier,Mikko Hiltunen,Isabelle Landrieu,Devrim Kilinc,Yann Herault,Jocelyn Laporte, Jean-Charles Lambert
Acta Neuropathol. 2019;May 7. doi: 10.1007/s00401-019-02017-9.

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Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons.

Ehrlich AT, Semache M, Gross F, Da Fonte DF, Runtz L, Colley C, Mezni A, Le Gouill C, Lukasheva V, Hogue M, Darcq E, Bouvier M, Kieffer BL.
Iscience. 2019;Apr 26;14:47-57. doi: 10.1016/j.isci.2019.03.011. Epub 2019 Mar 15.

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Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models.

Souchet B, Duchon A, Gu Y, Dairou J, Chevalier C, Daubigney F, Nalesso V, Créau N, Yu Y, Janel N, Herault Y, Delabar JM.
Sci Rep 2019;Mar 8;9(1):3914. doi: 10.1038/s41598-019-40328-9.

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2018


Single Intramuscular Injection of AAV-shRNA Reduces DNM2 and Prevents Myotubular Myopathy in Mice

Hichem Tasfaout, Valentina M. Lionello, Christine Kretz, Pascale Koebel, Nadia Messaddeq, Deborah Bitz, Jocelyn Laporte.
Molecular Therapy 2018;Vol 26, Issue 4, p1082-p1092, 4 April

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Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent manner

Kim YH, Noh JR, Hwang JH, Kim KS, Choi DH, Kim JH, Moon SJ, Choi JH, Hérault Y, Lee TG, Choi HS, Lee CH
Arch Toxicol 2018;Aug;92(8):2563-2572

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The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection

Hideki Hara, Sergey S Seregin , Dahai Yang, Koichi Fukase , Mathias Chamaillard, Emad S Alnemri , Naohiro Inohara, Grace Y Chen , Gabriel Núñez
Cell 2018;Nov 29;175(6):1651-1664

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Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation

Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW.
J Clin Invest 2018;Jun 1;128(6):2281-2296. doi: 10.1172/JCI93910. Epub 2018 Apr 30.

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2017


VMAT2-mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation.

Xu Y, Lu Y, Xu P, Mangieri LR, Isingrini E, Xu Y, Giros B and Tong Q.
Eneuro 2017;26

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RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis.

Han YH, Kim HJ, Na H, Nam MW, Kim JY, Kim JS, Koo SH, Lee MO.
Cell Rep. 2017;Jul 5;20(1):124-135.

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Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.

Fasano C, Rocchetti J, Pietrajtis K, Zander JF, Manseau F, Sakae DY, Marcus-Sells M, Ramet L, Morel LJ, Carrel D, Dumas S, Bolte S, Bernard V, Vigneault E, Goutagny R, Ahnert-Hilger G, Giros B, Daumas S, Williams S, El Mestikawy S.
Front Cell Neurosci 2017;May 16;11:140.

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Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing

Aliza T. Ehrlich, Meriem Semache, Julie Bailly, Stefan Wojcik, Tanzil M. Arefin, Christine Colley, Christian Le Gouill, Florence Gross,Viktoriya Lukasheva, Mireille Hogue, Emmanuel Darcq, Laura-Adela Harsan, Michel Bouvier, Brigitte L. Kieffer.
Brain Struct Funct 2017;Nov 6. doi: 10.1007/s00429-017-1547-3.

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Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction.

Libé-Philippot B, Michel V, Boutet de Monvel J, Le Gal S, Dupont T, Avan P, Métin C, Michalski N, Petit C.
Proc Natl Acad Sci U S A.  2017;Jul 25;114(30):7765-7774. Epub 2017 Jul 13.

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A molecular mechanism for the topographic alignment of convergent neural maps.

Savier E1, Eglen SJ2,3, Bathélémy A1, Perraut M1, Pfrieger FW1, Lemke G4, Reber M1,3.
Elife 2017;Mar 14;6. pii: e20470

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Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression.

Bonet C, Luciani F, Ottavi JF, Leclerc J, Jouenne FM, Boncompagni M, Bille K, Hofman V, Bossis G, Marco de Donatis G, Strub T, Cheli Y, Ohanna M, Luciano F, Marchetti S, Rocchi S, Birling MC, Avril MF, Poulalhon N, Luc T, Bertolotto C.
J Natl Cancer Inst 2017;Aug 1;109(8):djw340

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Col4a1 mutation generates vascular abnormalities correlated with neuronal damage in a mouse model of HANAC syndrome

Alix Trouillet, Henri Lorach, Elisabeth Dubus, Brahim El Mathari, Ivana Ivkovic, Julie Dégardin, Manuel Simonutti, Michel Paques, Xavier Guillonneau, Florian Sennlaub, José-Alain Sahel, Pierre Ronco, Emmanuelle Plaisier, Serge Picaud
Neurobiology Of Disease 2017;-

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Loss of the Methyl-CpG-Binding Protein ZBTB4 Alters Mitotic Checkpoint, Increases Aneuploidy, and Promotes Tumorigenesis.

Roussel-Gervais A, Naciri I, Kirsh O, Kasprzyk L, Velasco G, Grillo G, Dubus P, Defossez PA.
Cancer Res. 2017;Jan 1;77(1):62-73.

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Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson’s disease motor symptoms without neuronal degeneration in adult mice.

Isingrini E, Guinaudie C, Perret LC, Rainer Q, Moquin L, Gratton A, Giros B.
Scientific Reports 2017;7, 12432.

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Remodeling of Sensorimotor Brain Connectivity in Gpr88-Deficient Mice.

Arefin TM, Mechling AE, Meirsman AC, Bienert T, Hübner NS, Lee HL, Ben Hamida S, Ehrlich A, Roquet D, Hennig J, von Elverfeldt D, Kieffer BL, Harsan LA.
Brain Connect. 2017;Oct;7(8):526-540.

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2016


Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist.

Meirsman AC1, Le Merrer J2, Pellissier LP3, Diaz J4, Clesse D5, Kieffer BL6, Becker JA2.
Biol Psychiatry. 2016;Jun 1;79(11):917-27

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The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity

Yohan Roulland, Khalid Ouararhni, Mladen Naidenov, Lorrie Ramos, Muhammad Shuaib, Sajad Hussain Syed, Imtiaz Nizar Lone, Ramachandran Boopathi, Emeline Fontaine, Gabor Papai, Hiroaki Tachiwana, Thierry Gautier, Dimitrios Skoufias, Kiran Padmanabhan, Jan Bednar, Hitoshi Kurumizaka, Patrick Schultz, Dimitar Angelov, Ali Hamiche, Stefan Dimitrov
Molecular Cell 2016;2016 Aug 18;63(4):674-68

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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for DrugDevelopment in Down Syndrome.

Duchon A, Herault Y.
Front Behav Neurosci. 2016;3;10:104.

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GPR88 in A2AR Neurons Enhances Anxiety-Like Behaviors

Aura Carole Meirsman, Anne Robé, Alban de Kerchove d’Exaerde, and Brigitte Lina Kieffer
Eneuro.. 2016;Jul-Aug; 3(4)

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The Cannabinoid Receptor 2 Protects Against Alcoholic Liver Disease Via a Macrophage Autophagy-Dependent Pathway.

Denaës T, Lodder J, Chobert MN, Ruiz I, Pawlotsky JM, Lotersztajn S, Teixeira-Clerc F.
Sci Rep. 2016;Jun 27;6:28806.

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Resilience against chronic stress is mediated by noradrenergic regulation of dopamine neurons.

Isingrini E, Perret L, Rainer Q, Amilhon B, Guma E, Tanti A, Martin G, Robinson J, Moquin L, Marti F, Mechawar N, Williams S, Gratton A, Giros B.
Nature Neuroscience 2016;19, 560-563.

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Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice.

Diaz-Castroverde S, Gómez-Hernández A, Fernández S, García-Gómez G, Di Scala M, González-Aseguinolaza G, Fernández-Millán E, González-Rodríguez Á, García-Bravo M, Chambon P, Álvarez C, Perdomo L, Beneit N, Escribano O, Benito M.
Dis Model Mech. 2016; Nov 1;9(11):1271-1281.

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Selective genetic disruption of dopaminergic, serotoninergic and noradrenergic neurotransmission: insights into motor, emotional and addictive behavior.

Isingrini E, Perret L, Rainer Q, Sagueby S, Moquin L, Gratton A, Giros B.
J Psychiatry Neurosci 2016;41, 169-181.

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Pharmacological evaluation of orexin receptor antagonists in preclinical animal models of pain.

McDonald T, Liang HA, Sanoja R, Gotter AL, Kuduk SD, Coleman PJ, Smith KM, Winrow CJ, Renger JJ.
J Neurogenet. 2016;Mar;30(1):32-41.

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Rev-erbα in the brain is essential for circadian food entrainment.

Delezie J, Dumont S, Sandu C, Reibel S, Pevet P, Challet E.
Sci Rep. 2016;Jul 6;6:29386.

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A suppressor locus for MODY3-diabetes.

Garcia-Gonzalez MA, Carette C, Bagattin A, Chiral M, Makinistoglu MP, Garbay S, Prévost G, Madaras C, Hérault Y, Leibovici M, Pontoglio M.
Sci Rep. 2016;Sep 26;6:33087. doi: 10.1038/srep33087.

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Mu Opioid Receptors in Gamma-Aminobutyric Acidergic Forebrain Neurons Moderate Motivation for Heroin and Palatable Food

Pauline Charbogne, Olivier Gardon, Elena Martín-García, Helen L. Keyworth, Aya Matsui, Anna E. Mechling, Thomas Bienert, Taufiq Nasseef, Anne Robé, Luc Moquin, Emmanuel Darcq, Sami Ben Hamida, Patricia Robledo, Audrey Matifas, Katia Befort, Claire Gavériaux-Ruff, Laura-Adela Harsan, Dominik von Elverfeldt, Jurgen Hennig, Alain Gratton, Ian Kitchen, Alexis Bailey, Veronica A. Alvarez, Rafael Maldonado, and Brigitte L. Kieffer
Biological Psychiatry 2016;Dec 26. pii: S0006-3223(16)33156-0

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The DNA methyltransferase DNMT3C protects male germ cells from transposon activity.

Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Hérault Y, Guillou F, Bourc'his D.
Science 2016;Nov 18;354(6314):909-912.

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2015


Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization

Nicolas Rama 1, Alexandre Dubrac 2, Thomas Mathivet 3, Róisín-Ana Ní Chárthaigh 1, Gael Genet 2, Brunella Cristofaro 3, Laurence Pibouin-Fragner 3, Le Ma 4, Anne Eichmann 5, Alain Chédotal 1
Nat Med. 2015;21

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The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO2

Pierre-Louis Ruffault, Fabien D’Autrévaux, John A Hayes, Marc Nomaksteinsky, Sandra Autran, Tomoyuki Fujiyama, Mikio Hoshino, Martin Hägglund Ole Kiehn, Jean-François Brunet, Gilles Fortin, Christo Goridis
Elife 2015;-

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Generation and Validation of miR-142 Knock Out Mice

Amit Shrestha,Gianni Carraro,Elie El Agha,Regina Mukhametshina,Cho-Ming Chao,Albert Rizvanov, Guillermo Barreto, Saverio Bellusci
Plos One. 2015;Sep 1;10(9):e0136913.

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Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly

Takashi Ishiuchi, Rocio Enriquez-Gasca, Eiji Mizutani, Ana Bošković, Celine Ziegler-Birling, Diego Rodriguez-Terrones, Teruhiko Wakayama, Juan M Vaquerizas & Maria-Elena Torres-Padilla
Nat Struct Mol Biol. 2015; Aug 3. doi: 10.1038/nsmb.3066. [Epub ahead of print]

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A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects.

Huet T, Laverny G, Ciesielski F, Molnár F, Ramamoorthy TG, Belorusova AY, Antony P, Potier N, Metzger D, Moras D, Rochel N.
Cell Rep. 2015;Feb 3;10(4):516-26.

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Nociceptin/Orphanin-FQ Modulation of Learning and Memory.

Abdel-Mouttalib O.
Vitam Horm. 2015;97:323-45

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2014


Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions

Adlanmerini M, Solinhac R, Abot A, Fabre A, Raymond-Letron I, Guihot AL, Boudou F, Sautier L, Vessières E, Kim SH, Lière P, Fontaine C, Krust A, Chambon P, Katzenellenbogen JA, Gourdy P, Shaul PW, Henrion D, Arnal JF, Lenfant F.
Proc Natl Acad Sci U S A. 2014;Jan 14;111(2):E283-90

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Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits.

De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, Bäckhed F, Mithieux G.
Cell 2014;Jan 16;156(1-2):84-96.

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Intestinal gluconeogenesis is crucial to maintain a physiological fasting glycemia in the absence of hepatic glucose production in mice.

Penhoat A, Fayard L, Stefanutti A, Mithieux G, Rajas F
Metabolism 2014;Jan;63(1):104-11

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NOS2 expression is restricted to neurons in the healthy brain but is triggered in microglia upon inflammation.

Béchade C, Colasse S, Diana MA, Rouault M, Bessis A.
Glia 2014;62(6):956-63

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The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.

Labialle S1, Marty V1, Bortolin-Cavaillé ML1, Hoareau-Osman M1, Pradère JP2, Valet P2, Martin PG3, Cavaillé J4.
Embo J. 2014;Oct 1;33(19):2216-30.

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Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

Rachdi L, Kariyawasam D, Aïello V, Herault Y, Janel N, Delabar JM, Polak M, Scharfmann R.
Cell Cycle 2014;Jul 15;13(14):2221-9

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Cognition and hippocampal plasticity in the mouse is altered by monosomy of a genomic region implicated in Down syndrome

Sahún I, Marechal D, Pereira PL, Nalesso V, Gruart A, Garcia JM, Antonarakis SE, Dierssen M, Herault Y
Genetics 2014; Jul;197(3):899-912.

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Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.

Weinl C, Wasylyk C, Garcia Garrido M, Sothilingam V, Beck SC, Riehle H, Stritt C, Roux MJ, Seeliger MW, Wasylyk B, Nordheim A
Plos One 2014;Sep 9;9(9):e107048

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Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder.

Segura-Puimedon M, Sahún I, Velot E, Dubus P, Borralleras C, Rodrigues AJ, Valero MC, Valverde O, Sousa N, Herault Y, Dierssen M, Pérez-Jurado LA, Campuzano V.
Hum Mol Genet. 2014;Dec 15;23(24):6481-94

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Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

De la Torre R, De Sola S, Pons M, Duchon A, de Lagran MM, Farré M, Fitó M, Benejam B, Langohr K, Rodriguez J, Pujadas M, Bizot JC, Cuenca A, Janel N, Catuara S, Covas MI, Blehaut H, Herault Y, Delabar JM, Dierssen M.
Mol Nutr Food Res. 2014;Feb;58(2):278-88

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The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids

Olivia Tort, Sebastián Tanco, Cecilia Rocha, Ivan Bièche, Cecilia Seixas, Christophe Bosc, Annie Andrieux, Marie-Jo Moutin, Francesc Xavier Avilés, Julia Lorenzo and Carsten Janke
Mol Biol Cell. 2014;Oct 1; 25(19): 3017–3027

LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity.

Tajan M, Batut A, Cadoudal T, Deleruyelle S, Le Gonidec S, Saint Laurent C, Vomscheid M, Wanecq E, Tréguer K, De Rocca Serra-Nédélec A, Vinel C, Marques MA, Pozzo J, Kunduzova O, Salles JP, Tauber M, Raynal P, Cavé H, Edouard T, Valet P, Yart A.
Pnas 2014;Oct 21;111(42):E4494-503.

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Proteomic survey reveals altered energetic patterns and metabolic failure prior to retinal degeneration.

Griciuc A, Roux MJ, Merl J, Giangrande A, Hauck SM, Aron L, Ueffing M.
J Neurosci 2014;Feb 19;34(8):2797-812.

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Domains of genome-wide gene expression dysregulation in Down's syndrome.

Letourneau A, Santoni FA, Bonilla X, Sailani MR, Gonzalez D, Kind J, Chevalier C, Thurman R, Sandstrom RS, Hibaoui Y, Garieri M, Popadin K, Falconnet E, Gagnebin M, Gehrig C, Vannier A, Guipponi M, Farinelli L, Robyr D, Migliavacca E, Borel C, Deutsch S, Feki A, Stamatoyannopoulos JA, Herault Y, van Steensel B, Guigo R, Antonarakis SE
Nature 2014;Apr 17;508(7496):345-50

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The Gdap1 knockout mouse mechanistically links redox control to Charcot-Marie-Tooth disease.

Niemann A, Huber N, Wagner KM, Somandin C, Horn M, Lebrun-Julien F, Angst B, Pereira JA, Halfter H, Welzl H, Feltri ML, Wrabetz L, Young P, Wessig C, Toyka KV, Suter U.
Brain 2014;Mar;137(Pt 3):668-82

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Dendrite Self-Avoidance Requires Cell-Autonomous Slit/Robo Signaling in Cerebellar Purkinje Cells

Daniel A. Gibson, Stephen Tymanskyj, Rachel C. Yuan, Haiwen C. Leung, Julie L. Lefebvre, Joshua R., Sanes, Alain Chédotal and Le Ma
Neuron 2014;81

2013


Robo3-driven axon midline crossing conditions functional maturation of a large commissural synapse.

Michalski N, Babai N, Renier N, Perkel DJ, Chédotal A, Schneggenburger R.
Neuron. 2013;Jun 5;78(5):855-68

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Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.

Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass CK.
Nature 2013; Jun 27;498(7455):511-5.

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Postnatal growth defects in mice with constitutive depletion of central serotonin.

Narboux-Nême N, Angenard G, Mosienko V, Klempin F, Pitychoutis PM, Deneris E, Bader M, Giros B, Alenina N, Gaspar P.
Acs Chem Neurosci. 2013;4, 171-181

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Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin.

Diaz SL, Narboux-Nême N, Trowbridge S, Scotto-Lomassese S, Kleine Borgmann FB, Jessberger S, Giros B, Maroteaux L, Deneris E, Gaspar P.
Eur J Neurosci 2013;38, 2650-2658.

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Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening

David Adams, Richard Baldock, Shoumo Bhattacharya, Andrew J. Copp, Mary Dickinson, Nicholas D. E. Greene, Mark Henkelman, Monica Justice, Timothy Mohun, Stephen A. Murray, Erwin Pauws, Michael Raess, Janet Rossant,Tom Weaver, and David West.
Dis Model Mech. 2013;May-Jun;6(3):571-9

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The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye.

Berry DC, Jacobs H, Marwarha G, Gely-Pernot A, O'Byrne SM, DeSantis D, Klopfenstein M, Feret B, Dennefeld C, Blaner WS, Croniger CM, Mark M, Noy N, Ghyselinck NB.
J Biol Chem. 2013;Aug 23;288(34):24528-39.

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Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis.

Kabashi E, El Oussini H, Bercier V, Gros-Louis F, Valdmanis PN, McDearmid J, Mejier IA, Dion PA, Dupre N, Hollinger D, Sinniger J, Dirrig-Grosch S, Camu W, Meininger V, Loeffler JP, René F, Drapeau P, Rouleau GA, Dupuis L.
Hum Mol Genet. 2013;Jun 15;22(12):2350-60.

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JAK2V617F expression in mice amplifies early hematopoietic cells and gives them a competitive advantage that is hampered by IFNα.

Hasan S, Lacout C, Marty C, Cuingnet M, Solary E, Vainchenker W, Villeval JL.
Blood 2013;Aug 22 ;122(8):1464-77

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Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout Mice

Raphaël Weibel, David Reiss, Laurie Karchewski, Olivier Gardon, Audrey Matifas, Dominique Filliol, Jérôme A. J. Becker, John N. Wood, Brigitte L. Kieffer, and Claire Gaveriaux-Ruff
Plos One. 2013;8(9): e74706.

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p53-PGC-1a Pathway Mediates Oxidative Mitochondrial Damage and Cardiomyocyte Necrosis Induced by Monoamine Oxidase-A Upregulation: Role in Chronic Left Ventricular Dysfunction in Mice

Christelle Villeneuve,1,2,* Ce´ line Guilbeau-Frugier,1,2,* Pierre Sicard,1,2 Olivier Lairez,1,2 Catherine Ordener,1,2 Thibaut Duparc,1,2 Damien De Paulis,3,4 Bettina Couderc,2 Odile Spreux-Varoquaux,5 Florence Tortosa,1,2 Anne Garnier,6 Claude Knauf,1,2 Philippe Valet,1,2 Elisabetta Borchi,7 Chiara Nediani,7 Abdallah Gharib,3,4 Michel Ovize,3,4 Marie-Bernadette Delisle,1,2 Angelo Parini,1,2 and Jeanne Mialet-Perez1,2
Antioxidants & Redox Signaling 2013; Volume 18, Number 1

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Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis.

Ben M'Barek K1, Pla P, Orvoen S, Benstaali C, Godin JD, Gardier AM, Saudou F, David DJ, Humbert S.
J Neurosci. 2013;May 15;33(20):8608-20

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Dynamin 2 homozygous mutation in humans with a lethal congenital syndrome.

Koutsopoulos OS, Kretz C, Weller CM, Roux A, Mojzisova H, Böhm J, Koch C, Toussaint A, Heckel E, Stemkens D, Ter Horst SA, Thibault C, Koch M, Mehdi SQ, Bijlsma EK, Mandel JL, Vermot J, Laporte J.
Eur J Hum Genet. 2013;Jun;21(6):637-42

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Hepatic glucose sensing is required to preserve β cell glucose competence.

Seyer P, Vallois D, Poitry-Yamate C, Schütz F, Metref S, Tarussio D, Maechler P, Staels B, Lanz B, Grueter R, Decaris J, Turner S, da Costa A, Preitner F, Minehira K, Foretz M, Thorens B.
J Clin Invest. 2013;Apr;123(4):1662-76.

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Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease.

Nemazanyy I, Blaauw B, Paolini C, Caillaud C, Protasi F, Mueller A, Proikas-Cezanne T, Russell RC, Guan KL, Nishino I, Sandri M, Pende M, Panasyuk G.
Embo Mol Med. 2013;2013 Jun;5(6):870-90.

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Climbing fiber input shapes reciprocity of purkinje cell firing.

Badura A, Schonewille M, Voges K, Galliano E, Renier N, Gao Z, Witter L, Hoebeek FE, Chédotal A, De Zeeuw CI.
Neuron. 2013;May 22;78(4):700-13

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Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs

Mukherji A, Kobiita A, Ye T, Chambon P
Cell 2013;May 9;153(4):812-27

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Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.

Sun Z1, Feng D1, Fang B1, Mullican SE1, You SH1, Lim HW1, Everett LJ1, Nabel CS1, Li Y1, Selvakumaran V1, Won KJ1, Lazar MA2.
Mol Cell. 2013;26;52(6):769-82

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2012


LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: implications for Charcot-Marie-Tooth disease.

Somandin C, Gerber D, Pereira JA, Horn M, Suter U.
Glia 2012;Oct;60(10):1518-28.

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DYRK1A: a master regulatory protein controlling brain growth.

Guedj F, Pereira PL, Najas S, Barallobre MJ, Chabert C, Souchet B, Sebrie C, Verney C, Herault Y, Arbones M, Delabar JM.
Neurobiol Dis. 2012;Apr;46(1):190-203.

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Primary T-tubule and autophagy defects in the phosphoinositide phosphatase Jumpy/MTMR14 knockout mice muscle.

Hnia K, Kretz C, Amoasii L, Böhm J, Liu X, Messaddeq N, Qu CK, Laporte J.
Adv Biol Regul. 2012;Jan;52(1):98-107

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The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.

Raveau M, Lignon JM, Nalesso V, Duchon A, Groner Y, Sharp AJ, Dembele D, Brault V, Hérault Y.
Plos Genetic 2012;May;8(5):e1002724

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Epilepsy gene LGI1 regulates postnatal developmental remodeling of retinogeniculate synapses

Zhou YD, Zhang D, Ozkaynak E, Wang X, Kasper EM, Leguern E, Baulac S, Anderson MP
J Neurosci 2012;Jan 18;32(3):903-10

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BBS-Induced Ciliary Defect Enhances Adipogenesis, Causing Paradoxical Higher-Insulin Sensitivity, Glucose Usage, and decreased Inflammatory responseBS

Marion V, Mockel A, De Melo C, Obringer C, Claussmann A, Simon A, Messaddeq N, Durand M, Dupuis L, Loeffer JP, King P, Mutter-schmidt C, Petrovsky N, Stoetzel C, Dollfuss H
Cell Metabolism 2012;Sep 5;16(3):363-77

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Structural and Functional Concepts in Current Mouse Phenotyping and Archiving Facilities

Kollmus H, Post R, Brielmeier M, Fernández J, Fuchs H, McKerlie C, Montoliu L, Otaegui PJ, Rebelo M, Riedesel H, Ruberte J, Sedlacek R, de Angelis MH, Schughart K.
J Am Assoc Lab Anim Sci. 2012;Jul;51(4):418-35.

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Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells

Horn M, Baumann R, Pereira JA, Sidiropoulos PN, Somandin C, Welzl H, Stendel C, Lühmann T, Wessig C, Toyka KV, Relvas JB, Senderek J, Suter U
Brain. 2012;Dec;135(Pt 12):3567-83

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Pharmacological modulation of the retinal unfolded protein response in Bardet-Biedl syndrome reduces apoptosis and preserves light detection ability

Mockel A, Obringer C, Hakvoort TBM, Seeliger M, Lamers WH, Stoetzel C, Dollfus H, Marion V
Journal Of Biological Chemistry 2012;M112.386821

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Analysis of active chromatin modifications in early mammalian embryos reveals uncoupling of H2A.Z acetylation and H3K36 trimethylation from embryonic genome activation.

Bošković A, Bender A, Gall L, Ziegler-Birling C, Beaujean N, Torres-Padilla ME.
Epigenetics 2012;Jul;7(7):747-57

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The in vivo Down syndrome genomic library in mouse.

Herault Y, Duchon A, Velot E, Maréchal D, Brault V.
Prog Brain Res. 2012;197:169-97.

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The nuclear receptor REV-ERBalpha-/- is required for the daily balance of carbohydrate and lipid metabolism

Julien Delezie, Stéphanie Dumont, Hugues Dardente, Hugues Oudart, Aline Gréchez-Cassiau, Paul Klosen, Michèle Teboul, Franck Delaunay, Paul Pévet and Etienne Challet
Faseb 2012;26, 3321–3335

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An epigenetic silencing pathway controlling T helper 2 cell lineage commitment

Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, Roche D, Maison C, Quivy JP, Almouzni G, Amigorena S.
Nature 2012;Jul 12;487(7406):249-53.

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Control of ground-state pluripotency by allelic regulation of Nanog.

Miyanari Y, Torres-Padilla ME.
Nature 2012;Feb 12;483(7390):470-3

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Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.

Amoasii L, Bertazzi DL, Tronchère H, Hnia K, Chicanne G, Rinaldi B, Cowling BS, Ferry A, Klaholz B, Payrastre B, Laporte J, Friant S.
Plos Genet. 2012;2012;8(10):e1002965

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2011


Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine.

Goeldner C, Lutz PE, Darcq E, Halter T, Clesse D, Ouagazzal AM, Kieffer BL.
Biol Psychiatry. 2011;Feb 1;69(3):236-44

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Prmt2 regulates the lipopolysaccharide-induced responses in lungs and macrophages.

Dalloneau E, Pereira PL, Brault V, Nabel EG, Hérault Y.
J Immunol. 2011;Nov 1;187(9):4826-34.

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Necdin protects embryonic motoneurons from programmed cell death

Aebischer J, Sturny R, Andrieu D, Rieusset A, Schaller F, Geib S, Raoul C, Muscatelli F
Plos One 2011;6(9):e23764

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Severe Serotonin Depletion after Conditional Deletion of the Vesicular Monoamine Transporter 2 Gene in Serotonin Neurons: Neural and Behavioral Consequences

Narboux-Nême N, Sagné C, Doly S, Diaz SL, Martin CB, Angenard G, Martres MP, Giros B, Hamon M, Lanfumey L, Gaspar P, Mongeau R.
Neuropsychopharmacology 2011;36, 2538-2550.

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Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB.

Brault V, Martin B, Costet N, Bizot JC, Hérault Y.
Plos One 2011;6(11):e27845

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Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.

Duchon A, Raveau M, Chevalier C, Nalesso V, Sharp AJ, Herault Y.
Mamm Genome. 2011;Dec;22(11-12):674-84.

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The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome

Duchon A, Pothion S, Brault V, Sharp AJ, Tybulewicz VL, Fisher EM, Herault Y.
Behav Brain Res. 2011;Mar 1;217(2):271-81

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Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle.

Hnia K, Tronchère H, Tomczak KK, Amoasii L, Schultz P, Beggs AH, Payrastre B, Mandel JL, Laporte J.
J Clin Invest. 2011;Jan;121(1):70-85.

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Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia.

Gaveriaux-Ruff C, Nozaki C, Nadal X, Hever XC, Weibel R, Matifas A, Reiss D, Filliol D, Nassar MA, Wood JN, Maldonado R, Kieffer BL.
Pain 2011;Jun;152(6):1238-48.

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Influence of endogenous opioid systems on T lymphocytes as assessed by the knockout of mu, delta and kappa opioid receptors.

Karaji AG, Reiss D, Matifas A, Kieffer BL, Gavériaux-Ruff C.
J Neuroimmune Pharmacol. 2011;Dec;6(4):608-16

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Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing.

Billon-Galés A, Krust A, Fontaine C, Abot A, Flouriot G, Toutain C, Berges H, Gadeau AP, Lenfant F, Gourdy P, Chambon P, Arnal JF.
Proc Natl Acad Sci U S A 2011;Aug 9;108(32):13311-6

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Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone.

Börjesson AE, Windahl SH, Lagerquist MK, Engdahl C, Frenkel B, Movérare-Skrtic S, Sjögren K, Kindblom JM, Stubelius A, Islander U, Antal MC, Krust A, Chambon P, Ohlsson C.
Proc Natl Acad Sci U S A 2011;Apr 12;108(15):6288-93

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A bacterial protein targets the BAHD1 chromatin complex to stimulate type III interferon response.

Lebreton A, Lakisic G, Job V, Fritsch L, Tham TN, Camejo A, Matteï PJ, Regnault B, Nahori MA, Cabanes D, Gautreau A, Ait-Si-Ali S, Dessen A, Cossart P, Bierne H.
Science 2011;Mar 11;331(6022):1319-21

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Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia

Caberlotto E, Michel V, Foucher I, Bahloul A, Goodyear RJ, Pepermans E, Michalski N, Perfettini I, Alegria-Prévot O, Chardenoux S, Do Cruzeiro M, Hardelin JP, Richardson GP, Avan P, Weil D, Petit C
Proc Natl Acad Sci U S A 2011;Apr 5;108(14):5825-30

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Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

Boehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson A, Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F, Dantzer F
Proc Natl Acad Sci U S A 2011;Feb 15;108(7):2783-8

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Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas

Mutel E, Abdul-Wahed A, Ramamonjisoa N, Stefanutti A, Houberdon I, Cavassila S, Pilleul F, Beuf O, Gautier-Stein A, Penhoat A, Mithieux G, Rajas F
J Hepatol 2011;Mar;54(3):529-37

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Protein-induced satiety is abolished in the absence of intestinal gluconeogenesis

Penhoat A, Mutel E, Amigo-Correig M, Pillot B, Stefanutti A, Rajas F, Mithieux G
Physiol Behav 2011;Nov 30;105(1):89-93

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Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

Qiaolin Deng 1, Elisabet Andersson, Eva Hedlund, Zhanna Alekseenko, Eva Coppola, Lia Panman, James H Millonig, Jean-Francois Brunet, Johan Ericson, Thomas Perlmann
Development (Cambridge, England) 2011;-

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2010


Removal of the calpain 3 protease reverses the myopathology in a mouse model for titinopathies

Karine Charton 1, Nathalie Danièle, Anna Vihola, Carinne Roudaut, Evelyne Gicquel, François Monjaret, Anne Tarrade, Jaakko Sarparanta, Bjarne Udd, Isabelle Richard
Human Molecular Genetics 2010;-

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Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3.

Santenard A, Ziegler-Birling C, Koch M, Tora L, Bannister AJ, Torres-Padilla ME.
Nat Cell Biol 2010;Sep;12(9):853-62

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Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape

Etournay R, Lepelletier L, Boutet de Monvel J, Michel V, Cayet N, Leibovici M, Weil D, Foucher I, Hardelin JP, Petit C
Development 2010;Apr;137(8):1373-83

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Electroclinical characterization of epileptic seizures in leucine-rich, glioma-inactivated 1-deficient mice

Chabrol E, Navarro V, Provenzano G, Cohen I, Dinocourt C, Rivaud-Péchoux S, Fricker D, Baulac M, Miles R, Leguern E, Baulac S
Brain 2010;Sep;133(9):2749-62

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Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids

Bahloul A, Michel V, Hardelin JP, Nouaille S, Hoos S, Houdusse A, England P, Petit C
Human Molecular Genetics 2010;Volume 19

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Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice

Kumar R, Bourbon HM, de Massy B
Genes Dev. 2010;Jun 15;24(12):1266-80

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A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene

Schaller F, Watrin F, Sturny R, Massacrier A, Szepetowski P, Muscatelli F
Hum Mol Genet 2010;Dec 15;19(24):4895-905.

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Jarid2 and PRC2, partners in regulating gene expression.

Li G1, Margueron R, Ku M, Chambon P, Bernstein BE, Reinberg D.
Genes Dev. 2010;15;24(4):368-80.

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Controlled Somatic and Germline Copy Number Variation in the Mouse Model

Yann Hérault, Arnaud Duchon, Damien Maréchal, Matthieu Raveau, Patricia L. Pereira, Emilie Dalloneau and Véronique Brault
Current Genomics 2010;11, 470-480

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Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues.

Velasco G, Hubé F, Rollin J, Neuillet D, Philippe C, Bouzinba-Segard H, Galvani A, Viegas-Péquignot E, Francastel C.
Proc Natl Acad Sci U S A. 2010;2010 May 18;107(20):9281-6

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Genetic dissection of the function of hindbrain axonal commissures.

Renier N, Schonewille M, Giraudet F, Badura A, Tessier-Lavigne M, Avan P, De Zeeuw CI, Chédotal A.
Plos Biol. 2010;Mar 9;8(3):e1000325

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A centronuclear myopathy-dynamin 2 mutation impairs skeletal muscle structure and function in mice.

Durieux AC, Vignaud A, Prudhon B, Viou MT, Beuvin M, Vassilopoulos S, Fraysse B, Ferry A, Lainé J, Romero NB, Guicheney P, Bitoun M.
Hum Mol Genet. 2010;Dec 15;19(24):4820-36.

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2009


T-tubule disorganization and defective excitation-contraction coupling in muscle fibers lacking myotubularin lipid phosphatase.

Al-Qusairi L, Weiss N, Toussaint A, Berbey C, Messaddeq N, Kretz C, Sanoudou D, Beggs AH, Allard B, Mandel JL, Laporte J, Jacquemond V, Buj-Bello A.
Proc Natl Acad Sci U S A 2009;Nov 3;106(44):18763-8.

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The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol.

Billon-Galés A, Fontaine C, Filipe C, Douin-Echinard V, Fouque MJ, Flouriot G, Gourdy P, Lenfant F, Laurell H, Krust A, Chambon P, Arnal JF.
Proc Natl Acad Sci U S A 2009;Feb 10;106(6):2053-8

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TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte.

Gazdag E, Santenard A, Ziegler-Birling C, Altobelli G, Poch O, Tora L, Torres-Padilla ME.
Genes Dev. 2009;Sep 15;23(18):2210-23

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2008


Erythropoietic porphyrias: animal models and update in gene-based therapies

Richard E, Robert-Richard E, Ged C, Moreau-Gaudry F, de Verneuil H
Curr Gene Ther 2008;Jun;8(3):176-86

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Successful gene therapy of mice with congenital erythropoietic porphyria

de Verneuil H, Robert-Richard E, Ged C, Mazurier F, Richard E, Moreau-Gaudry F
Med Sci (Paris) 2008;Jun-Jul;24(6-7):615-20

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Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERbeta-null mutant.

Antal MC, Krust A, Chambon P, Mark M.
Proc Natl Acad Sci U S A 2008;Feb 19;105(7):2433-8

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Effective gene therapy of mice with congenital erythropoietic porphyria is facilitated by a survival advantage of corrected erythroid cells

Robert-Richard E, Moreau-Gaudry F, Lalanne M, Lamrissi-Garcia I, Cario-André M, Guyonnet-Dupérat V, Taine L, Ged C, de Verneuil H
Am J Hum Genet 2008;Jan;82(1):113-24

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Disruption of Krox20–Nab Interaction in the Mouse Leads to Peripheral Neuropathy with Biphasic Evolution

Desmazières A, Decker L, Vallat JM, Charnay P, Gilardi-Hebenstreit P.
J Neurosci. 2008; Jun 4;28(23):5891-900

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Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: comparison to morphine.

Reiss D, Wichmann J, Tekeshima H, Kieffer BL, Ouagazzal AM.
Eur J Pharmacol. 2008;Jan 28;579(1-3):141-8.

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2006


A knock-in mouse model of congenital erythropoietic porphyria

Ged C, Mendez M, Robert E, Lalanne M, Lamrissi-Garcia I, Costet P, Daniel JY, Dubus P, Mazurier F, Moreau-Gaudry F, de Verneuil H
Genomics 2006;Jan;87(1):84-92

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Knockin mice expressing fluorescent δ-opioid receptors uncover G protein-coupled receptor dynamics invivo

Grégory Scherrer, Petra Tryoen-Tóth, Dominique Filliol, Audrey Matifas, Delphine Laustriat, Yu Q. Cao, Allan I. Basbaum, Andrée Dierich, Jean-Luc Vonesh, Claire Gavériaux-Ruff, and Brigitte L. Kieffer
Pnas 2006;103 (25) 9691-9696

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Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death

Andrieu D, Meziane H, Marly F, Angelats C, Fernandez PA, Muscatelli F
Bmc Dev Biol 2006;20;6:56

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2004


Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model.

Helmlinger D, Abou-Sleymane G, Yvert G, Rousseau S, Weber C, Trottier Y, Mandel JL, Devys D.
J Neurosci. 2004;25;24(8):1881-7

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Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

El Marjou F., Janssen K.P., Hung-Junn Chang B., Li M., Hindie V., Chan L., Louvard D., Chambon P., Metzger D., Robine S
Genesis 2004;Jul;39(3):186-93.

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2002


The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice.

Buj-Bello A, Laugel V, Messaddeq N, Zahreddine H, Laporte J, Pellissier JF, Mandel JL.
Proc Natl Acad Sci U S A 2002;Nov 12;99(23):15060-5

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Progressive retinal degeneration and dysfunction in R6 Huntington's disease mice.

Helmlinger D, Yvert G, Picaud S, Merienne K, Sahel J, Mandel JL, Devys D.
Hum Mol Genet 2002;15;11(26):3351-9

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