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Pentylene-tetrazol induced seizures


This test is frequently used for screening of the potential antiepileptic drugs and is based on the excitotoxic properties of pentylene-tetrazol (PTZ). This substance acts as a non-competitive GABA-A receptor antagonist that reduces neuronal inhibition.  

Sample test results

Meldrum B. 
Do preclinical seizure models preselect certain adverse effects of antiepileptic drugs. 
Epilepsy Res. 2002 Jun;50(1-2):33-40.


There is no dedicated equipment: observation and manual scoring


10 mice per group are recommended for reliable data analysis

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