IMPC publications

"Two major papers from the International Mouse Phenotyping Consortium have been published in Nature Genetics and Nature Communications. The research marks a vital step forward in the IMPC’s goal of creating a comprehensive catalogue of mammalian gene function".

A new synapse disease discovered

A new synapse disease discovered at the base of Autism and intellectual disabilities caused by the deficiency of the PTCHD1 gene. The work is published in Molecular Psychiatry.

Technological jump !

the ICS developed the CRISPR Mediated REarrangement (CRISMERE) strategy to generate any kind of chromosomal rearrangement to generate mice and rat trisomy 21. Read the recent Scientific Report. Read the recent publication in Scientific Report

Integrated approach for bone pathology

We offer new capabilities for analysing bone dynamics including both in vivo and ex vivo analysis of trabecular and cortical bone structures by microCT. This augments our current capacities of skeletal examinations by TRAP histological stain, X-ray, DEXA scanning, and quantitative NMR.

Contact us for help in designing your experiments on bone dynamics!

Picture: Representative 3D volumes illustrating trabecular microarchitecture in the caudal vertebra (left) and cortical bone in the tibia (right) of Sham-operated and Ovarectomized (OVX) mice, 9 weeks after surgery.

 

Advanced Histological Stainings at ICS

ICS is proud to offer new capabilities for histological examinations, the Masson’s trichrome and the Russell-Movat pentachrome stains. 

Both these stains are excellent means for visualizing collagen deposits (fibroses), but with the Movat’s pentachrome stain one can also differentiate elastic fibres, muscle, mucin, and fibrin.  For detailed histological examinations or high quality images for publication, consider these stains to improve your understanding and impress your colleagues. 

Left picture: Masson trichrone staining of a heart with massive fibrosis (in blue)

Right picture: Movat Pentachrome Phamini modification: collagen is stained by light green

Neuromuscular Phenotyping

ICS is proud to offer novel assays for assessment of neuromuscular and muscular defects as part of our phenotyping. 

Mouse Reaching and Grasping (MoRaG) assay as well as automated gait (DigiGait) analysis now complement our existing grip strength, rotorod, and beam walking assays.  Along with  isolated muscular strength assays that are coming soon, we provide excellent capabilities to assess neuromuscular and muscular defects in your animals.