IMPC publications

"Two major papers from the International Mouse Phenotyping Consortium have been published in Nature Genetics and Nature Communications. The research marks a vital step forward in the IMPC’s goal of creating a comprehensive catalogue of mammalian gene function".

Webinars CRISPR/Cas9 in rodents

PHENOMIN-ICS presented 2 webinars on CRISPR/Cas 9 in rodents that were hosted by our partner Charles River.

• CRISPR/Cas9 in Rodents Animals: The good, The bad and the ugly
• Modelling Human Disease in Rodents with CRISPR/Cas9 Genome Editing  

We are pleased to remind they are now avaibale as replay !

Technological jump !

the ICS developed the CRISPR Mediated REarrangement (CRISMERE) strategy to generate any kind of chromosomal rearrangement to generate mice and rat trisomy 21. Read the recent Scientific Report. Read the recent publication in Scientific Report

Integrated approach for bone pathology

We offer new capabilities for analysing bone dynamics including both in vivo and ex vivo analysis of trabecular and cortical bone structures by microCT. This augments our current capacities of skeletal examinations by TRAP histological stain, X-ray, DEXA scanning, and quantitative NMR.

Contact us for help in designing your experiments on bone dynamics!

Picture: Representative 3D volumes illustrating trabecular microarchitecture in the caudal vertebra (left) and cortical bone in the tibia (right) of Sham-operated and Ovarectomized (OVX) mice, 9 weeks after surgery.

 

A new synapse disease discovered

A new synapse disease discovered at the base of Autism and intellectual disabilities caused by the deficiency of the PTCHD1 gene. The work is published in Molecular Psychiatry.

Neuromuscular Phenotyping

ICS is proud to offer novel assays for assessment of neuromuscular and muscular defects as part of our phenotyping. 

Mouse Reaching and Grasping (MoRaG) assay as well as automated gait (DigiGait) analysis now complement our existing grip strength, rotorod, and beam walking assays.  Along with  isolated muscular strength assays that are coming soon, we provide excellent capabilities to assess neuromuscular and muscular defects in your animals.