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IGBMC resulted from the fusion of two Strasbourg laboratories, the Laboratory of Molecular Genetics of Eukaryotes (LGME) and the Structural Biology Laboratory, led respectively by Pierre Chambon and Dino Moras. The Institute was built in 1990 with the support of the CNRS, Inserm, University Louis Pasteur of Strasbourg and the pharmaceutical company Bristol-Myers-Squibb, on the "Parc d’Innovation d’Illkirch" site, a competitive centre dedicated to scientific research and biotechnologies.

Since its inauguration in 1994, researchers at the IGBMC are recognized for the excellence of their results on the international scientific scene. Under the direction of Pierre Chambon (1994-2002), the research conducted by the teams mainly addressed the question of the regulation of gene expression. From 2002 to 2009, the Institute was co-directed by Jean-Louis Mandel and Dino Moras, who developed the human genetics and structural biology axes. From October 2009 to 2012, the IGBMC has been led by Olivier Pourquié, specialist in the development of muscles and vertebrae. From June 2012 to December 2013, Brigitte Kieffer, whose research on opioid receptors is internationally acclaimed, has been appointed Director of the Institute. The domains of investigation carried out by the Institute range from developmental biology to integrative structural biology, via functional genomics, cancer, translational medicine and neurogenetics.

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Bertrand Séraphin and Yann Hérault have been appointed respectively Director and Deputy Director and have taken the helm of the Institute from the beginning of 2014. 

Research director at the CNRS, Bertrand Séraphin is a specialist in the decay of messenger RNA and the characterization of protein complexes. After spending several years at the EMBL and the CGM (Gif-sur-Yvette, France), he joined the IGBMC with his team in 2009. He has received several national and international awards, including the Silver Medal of the CNRS in 2007.

Meanwhile, Yann Hérault currently leads the Mouse Clinical Institute (ICS) and coordinates the Phenomin national project. Research Director at the CNRS, he recently received the Sisley-Jérôme Lejeune prize for his work on Down syndrome (trisomy 21).

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