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The Nuclear Receptor Zoo mouse resource from the Institut Clinique de la Souris (ICS) is a collection of Nuclears Receptors and Coregulators genetically engineered models, either as conditional or total knock-out mutant (available as live animals and/or frozen materials).

The mouse lines described here are available for academic users under MTA agreement and distribution fees. The fees for these animals are calculated on cost recovery basis and are used to recover animal husbandry and stock replacement costs (fees do not include the costs for shipping the material from the ICS facility to the recipient's institution.).

Distribution fees

Live Mice (6-7 weeks of age, 2-3 Breeding pairs): 3200 €
Cryopreserved embryos (about 50 embryos in 2 straws): 1600 €

In most of the case only heterozygous carrier has been used for archiving and thus the distributed materiel may contain carrier (mutant or transgenic) and control (not mutant or not transgenic) embryos or gametes. ICS offers additional breeding services to e.g. generate cohorts of homozygous mutants. A quotation for such a service is available upon request.

Please note that all the lines are not specifically maintained for distribution. We thus cannot guaranty immediate shipment of live animals you requested. Once a request of interest is received, you will be contacted by email within a week to give you an up-to date availability of the requested line.

More Details on the restrictions, on PI and on the distribution is available upon request.

Gene name	Other gene name	Reference	Mutation types	Strain of origin	Genetic background	Status
CARa	NR1I3	MGI:1346307	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
CARa	NR1I3	MGI:1346307	knock-out	129S2/SvPas	C57BL/6J N3	Frozen Embryos
COUP-TF2	NR2F2	MGI:1352452	conditional knock-out	129S2/SvPas	C57BL/6J N4	Frozen Embryos
EAR2	NR2F6	MGI:1352453	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
EAR2	NR2F6	MGI:1352453	knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
ERR1	NR3B1	MGI:1346831	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
ERR1	NR3B1	MGI:1346831	knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
ERR2	NR3B2	MGI:1346832	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
ERR2	NR3B2	MGI:1346832	knock-out	129S2/SvPas	C57BL/6J N8	Frozen Embryos
ERR3	NR3B3, ERRg	MGI:1347056	knock-out	129S2/SvPas	C57BL/6J N9	Frozen Embryos
ERR3	NR3B3, ERRg	MGI:1347056	conditional knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
FXRa	NR1H4, RIP14, HRR1	MGI:1352464	knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
FXRa	NR1H4, RIP14, HRR1	MGI:1352464	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
GCNF1	NR6A1, RTR	MGI:1352459	knock-out	129S2/SvPas	C57BL/6J N9	Frozen Embryos
GCNF1	NR6A1, RTR	MGI:1352459	conditional knock-out	129S2/SvPas	C57BL/6J N4	Frozen Embryos
GR	NR3C1	MGI:95824	conditional knock-out	129S2/SvPas	C57BL/6J N6	Frozen Embryos
GR	NR3C1	MGI:95824	knock-out	129S2/SvPas	C57BL/6J N8	Frozen Embryos
HNF4a	NR2A1, HNF4	MGI:109128	conditional knock-out	129S2/SvPas	C57BL/6J N6	Frozen Embryos
HNF4a	NR2A1, HNF4	MGI:109128	knock-out	129S2/SvPas	C57BL/6J N6	Frozen Embryos
HNF4g	NR2A2	MGI:1353604	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
HNF4g	NR2A2	MGI:1353604	knock-out	129S2/SvPas	C57BL/6J N8	Frozen Embryos
LXRa	NR1H3, RLD1, LXR	MGI:1352462	knock-out	129S2/SvPas	C57BL/6J N10	Frozen Embryos
LXRa	NR1H3, RLD1, LXR	MGI:1352462	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
LXRb	NR1H2, UR, OR-1, NER1, RIP15	MGI:1352463	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
LXRb	NR1H2, UR, OR-1, NER1, RIP15	MGI:1352463	conditional knock-out	129S2/SvPas	C57BL/6J N8	Frozen Embryos
MR	NR3C2	MGI:99459	conditional knock-out	129S2/SvPas	C57BL/6J N6	Frozen Embryos
MR	NR3C2	MGI:99459	knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
Ncor1	Rip13	MGI:1349717	conditional knock-out	129S2/SvPas	C57BL/6J N8	Frozen Embryos
Ncor1	Rip13	MGI:1349717	knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
Ncor2	SMRT, N-CoR	MGI:1337080	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
Ncor2	SMRT, N-CoR	MGI:1337080	knock-out	129S2/SvPas	C57BL/6J N8	Frozen Embryos
PGC1-b		MGI:2444934	knock-out	C57BL/6N	C57BL/6J N3	Frozen Embryos
PGC1-b		MGI:2444934	conditional knock-out	C57BL/6N	C57BL/6N	Frozen Embryos
PNR	NR2E3	MGI:1346317	conditional knock-out	129S2/SvPas	C57BL/6J N6	Frozen Embryos
PNR	NR2E3	MGI:1346317	knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
PPARa	NR1C1	MGI:104740	knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
PPARa	NR1C1	MGI:104740	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
PR	NR3C3	MGI:97567	knock-out	129S2/SvPas	C57BL/6J N8	Frozen Embryos
PR	NR3C3	MGI:97567	conditional knock-out	129S2/SvPas	C57BL/6J N4	Frozen Embryos
PXR	NR1I2	MGI:1337040	knock-out	129S2/SvPas	C57BL/6J N8	Frozen Embryos
PXR	NR1I2	MGI:1337040	conditional knock-out	129S2/SvPas	C57BL/6J N8	Frozen Embryos
RAP-250	AIB3, PRIP	MGI:1929915	knock-out	129S2/SvPas	C57BL/6J N12	Frozen Embryos
RAP-250	AIB3, PRIP	MGI:1929915	conditional knock-out	129S2/SvPas	C57BL/6J N10	Frozen Embryos
REA	Bap	MGI:102520	conditional knock-out	129S2/SvPas	C57BL/6J N8	Frozen Embryos
REA	Bap	MGI:102520	knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
RevErbb	NR1D2, EAR1b, BD73, RVR, HZF2	MGI:2449205	knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
RevErbb	NR1D2, EAR1b, BD73, RVR, HZF2	MGI:2449205	conditional knock-out	129S2/SvPas	C57BL/6J N6	Frozen Embryos
RORa	NR1F1, RZRa	MGI:104661	conditional knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
RORa	NR1F1, RZRa	MGI:104661	knock-out	129S2/SvPas	C57BL/6J N4	Frozen Embryos
RORb	NR1F2, RZRb	MGI:1343464	knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
RORb	NR1F2, RZRb	MGI:1343464	conditional knock-out	129S2/SvPas	C57BL/6J N10	Frozen Embryos
RORg	NR1F3, TOR	MGI:104856	knock-out	129S2/SvPas	C57BL/6J N6	Frozen Embryos
RORg	NR1F3, TOR	MGI:104856	conditional knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
RXRg	NR2B3	MGI:98216	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
RXRg	NR2B3	MGI:98216	knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
SF1	NR5A1	MGI:1346833	knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
SF1	NR5A1	MGI:1346833	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
SHP	NR0B2	MGI:1346344	knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
SHP	NR0B2	MGI:1346344	conditional knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
SRC3	P/CIP	MGI:1276535	knock-out	129S2/SvPas	C57BL/6J N6	Frozen Embryos
SRC3	P/CIP	MGI:1276535	conditional knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
TLX	NR2E1	MGI:1100526	knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
TLX	NR2E1	MGI:1100526	conditional knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
TR4	NR2C2, TR2b, TAK1	MGI:1352466	knock-out	129S2/SvPas	C57BL/6J N6	Frozen Embryos
TR4	NR2C2, TR2b, TAK1	MGI:1352466	conditional knock-out	129S2/SvPas	C57BL/6J N8	Frozen Embryos
Trap220	PBP, DRIP205	MGI:1100846	conditional knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
Trap220	PBP, DRIP205	MGI:1100846	knock-out	129S2/SvPas	C57BL/6J N5	Frozen Embryos
TRb	NR1A2, c-erbA-2, THRB	MGI:98743	knock-out	129S2/SvPas	C57BL/6J N4	Frozen Embryos
TRb	NR1A2, c-erbA-2, THRB	MGI:98743	conditional knock-out	129S2/SvPas	C57BL/6J N4	Frozen Embryos
Trip-15	Alien	MGI:1330276	conditional knock-out	129S2/SvPas	C57BL/6J N7	Frozen Embryos
Trip-15	Alien	MGI:1330276	knock-out	129S2/SvPas	C57BL/6J N9	Frozen Embryos