The Nuclear Receptor Zoo mouse resource from the Institut Clinique de la Souris (ICS) is a collection of Nuclears Receptors and Coregulators genetically engineered models, either as conditional or total knock-out mutant (available as live animals and/or frozen materials).
The mouse lines described here are available for academic users under MTA agreement and distribution fees. The fees for these animals are calculated on cost recovery basis and are used to recover animal husbandry and stock replacement costs (fees do not include the costs for shipping the material from the ICS facility to the recipient's institution.).
Live Mice (6-7 weeks of age, 2-3 Breeding pairs): 3200 €
Cryopreserved embryos (about 50 embryos in 2 straws): 1600 €
In most of the case only heterozygous carrier has been used for archiving and thus the distributed materiel may contain carrier (mutant or transgenic) and control (not mutant or not transgenic) embryos or gametes. ICS offers additional breeding services to e.g. generate cohorts of homozygous mutants. A quotation for such a service is available upon request.
Please note that all the lines are not specifically maintained for distribution. We thus cannot guaranty immediate shipment of live animals you requested. Once a request of interest is received, you will be contacted by email within a week to give you an up-to date availability of the requested line.
More Details on the restrictions, on PI and on the distribution is available upon request.
Gene name | Other gene name | Reference | Mutation types | Strain of origin | Genetic background | Status |
---|---|---|---|---|---|---|
CARa | NR1I3 | MGI:1346307 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
CARa | NR1I3 | MGI:1346307 | knock-out | 129S2/SvPas | C57BL/6J N3 | Frozen Embryos |
COUP-TF2 | NR2F2 | MGI:1352452 | conditional knock-out | 129S2/SvPas | C57BL/6J N4 | Frozen Embryos |
EAR2 | NR2F6 | MGI:1352453 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
EAR2 | NR2F6 | MGI:1352453 | knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
ERR1 | NR3B1 | MGI:1346831 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
ERR1 | NR3B1 | MGI:1346831 | knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
ERR2 | NR3B2 | MGI:1346832 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
ERR2 | NR3B2 | MGI:1346832 | knock-out | 129S2/SvPas | C57BL/6J N8 | Frozen Embryos |
ERR3 | NR3B3, ERRg | MGI:1347056 | knock-out | 129S2/SvPas | C57BL/6J N9 | Frozen Embryos |
ERR3 | NR3B3, ERRg | MGI:1347056 | conditional knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
FXRa | NR1H4, RIP14, HRR1 | MGI:1352464 | knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
FXRa | NR1H4, RIP14, HRR1 | MGI:1352464 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
GCNF1 | NR6A1, RTR | MGI:1352459 | knock-out | 129S2/SvPas | C57BL/6J N9 | Frozen Embryos |
GCNF1 | NR6A1, RTR | MGI:1352459 | conditional knock-out | 129S2/SvPas | C57BL/6J N4 | Frozen Embryos |
GR | NR3C1 | MGI:95824 | conditional knock-out | 129S2/SvPas | C57BL/6J N6 | Frozen Embryos |
GR | NR3C1 | MGI:95824 | knock-out | 129S2/SvPas | C57BL/6J N8 | Frozen Embryos |
HNF4a | NR2A1, HNF4 | MGI:109128 | conditional knock-out | 129S2/SvPas | C57BL/6J N6 | Frozen Embryos |
HNF4a | NR2A1, HNF4 | MGI:109128 | knock-out | 129S2/SvPas | C57BL/6J N6 | Frozen Embryos |
HNF4g | NR2A2 | MGI:1353604 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
HNF4g | NR2A2 | MGI:1353604 | knock-out | 129S2/SvPas | C57BL/6J N8 | Frozen Embryos |
LXRa | NR1H3, RLD1, LXR | MGI:1352462 | knock-out | 129S2/SvPas | C57BL/6J N10 | Frozen Embryos |
LXRa | NR1H3, RLD1, LXR | MGI:1352462 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
LXRb | NR1H2, UR, OR-1, NER1, RIP15 | MGI:1352463 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
LXRb | NR1H2, UR, OR-1, NER1, RIP15 | MGI:1352463 | conditional knock-out | 129S2/SvPas | C57BL/6J N8 | Frozen Embryos |
MR | NR3C2 | MGI:99459 | conditional knock-out | 129S2/SvPas | C57BL/6J N6 | Frozen Embryos |
MR | NR3C2 | MGI:99459 | knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
Ncor1 | Rip13 | MGI:1349717 | conditional knock-out | 129S2/SvPas | C57BL/6J N8 | Frozen Embryos |
Ncor1 | Rip13 | MGI:1349717 | knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
Ncor2 | SMRT, N-CoR | MGI:1337080 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
Ncor2 | SMRT, N-CoR | MGI:1337080 | knock-out | 129S2/SvPas | C57BL/6J N8 | Frozen Embryos |
PGC1-b | MGI:2444934 | knock-out | C57BL/6N | C57BL/6J N3 | Frozen Embryos | |
PGC1-b | MGI:2444934 | conditional knock-out | C57BL/6N | C57BL/6N | Frozen Embryos | |
PNR | NR2E3 | MGI:1346317 | conditional knock-out | 129S2/SvPas | C57BL/6J N6 | Frozen Embryos |
PNR | NR2E3 | MGI:1346317 | knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
PPARa | NR1C1 | MGI:104740 | knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
PPARa | NR1C1 | MGI:104740 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
PR | NR3C3 | MGI:97567 | knock-out | 129S2/SvPas | C57BL/6J N8 | Frozen Embryos |
PR | NR3C3 | MGI:97567 | conditional knock-out | 129S2/SvPas | C57BL/6J N4 | Frozen Embryos |
PXR | NR1I2 | MGI:1337040 | knock-out | 129S2/SvPas | C57BL/6J N8 | Frozen Embryos |
PXR | NR1I2 | MGI:1337040 | conditional knock-out | 129S2/SvPas | C57BL/6J N8 | Frozen Embryos |
RAP-250 | AIB3, PRIP | MGI:1929915 | knock-out | 129S2/SvPas | C57BL/6J N12 | Frozen Embryos |
RAP-250 | AIB3, PRIP | MGI:1929915 | conditional knock-out | 129S2/SvPas | C57BL/6J N10 | Frozen Embryos |
REA | Bap | MGI:102520 | conditional knock-out | 129S2/SvPas | C57BL/6J N8 | Frozen Embryos |
REA | Bap | MGI:102520 | knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
RevErbb | NR1D2, EAR1b, BD73, RVR, HZF2 | MGI:2449205 | knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
RevErbb | NR1D2, EAR1b, BD73, RVR, HZF2 | MGI:2449205 | conditional knock-out | 129S2/SvPas | C57BL/6J N6 | Frozen Embryos |
RORa | NR1F1, RZRa | MGI:104661 | conditional knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
RORa | NR1F1, RZRa | MGI:104661 | knock-out | 129S2/SvPas | C57BL/6J N4 | Frozen Embryos |
RORb | NR1F2, RZRb | MGI:1343464 | knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
RORb | NR1F2, RZRb | MGI:1343464 | conditional knock-out | 129S2/SvPas | C57BL/6J N10 | Frozen Embryos |
RORg | NR1F3, TOR | MGI:104856 | knock-out | 129S2/SvPas | C57BL/6J N6 | Frozen Embryos |
RORg | NR1F3, TOR | MGI:104856 | conditional knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
RXRg | NR2B3 | MGI:98216 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
RXRg | NR2B3 | MGI:98216 | knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
SF1 | NR5A1 | MGI:1346833 | knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
SF1 | NR5A1 | MGI:1346833 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
SHP | NR0B2 | MGI:1346344 | knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
SHP | NR0B2 | MGI:1346344 | conditional knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
SRC3 | P/CIP | MGI:1276535 | knock-out | 129S2/SvPas | C57BL/6J N6 | Frozen Embryos |
SRC3 | P/CIP | MGI:1276535 | conditional knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
TLX | NR2E1 | MGI:1100526 | knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
TLX | NR2E1 | MGI:1100526 | conditional knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
TR4 | NR2C2, TR2b, TAK1 | MGI:1352466 | knock-out | 129S2/SvPas | C57BL/6J N6 | Frozen Embryos |
TR4 | NR2C2, TR2b, TAK1 | MGI:1352466 | conditional knock-out | 129S2/SvPas | C57BL/6J N8 | Frozen Embryos |
Trap220 | PBP, DRIP205 | MGI:1100846 | conditional knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
Trap220 | PBP, DRIP205 | MGI:1100846 | knock-out | 129S2/SvPas | C57BL/6J N5 | Frozen Embryos |
TRb | NR1A2, c-erbA-2, THRB | MGI:98743 | knock-out | 129S2/SvPas | C57BL/6J N4 | Frozen Embryos |
TRb | NR1A2, c-erbA-2, THRB | MGI:98743 | conditional knock-out | 129S2/SvPas | C57BL/6J N4 | Frozen Embryos |
Trip-15 | Alien | MGI:1330276 | conditional knock-out | 129S2/SvPas | C57BL/6J N7 | Frozen Embryos |
Trip-15 | Alien | MGI:1330276 | knock-out | 129S2/SvPas | C57BL/6J N9 | Frozen Embryos |