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Resources and Technologies

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To secure and to control the huge amount of data generated by all the operations, a Laboratory Information Management System (LIMS) has been developed. The ICS has a dedicated team of 4 people to manage its information system. The team has developed modern, web-based applications to capture process and analyse all relevant data of the ICS. These databases cover major activities (genetic engineering, animal facility, phenotyping), as well as transversal fields such as quality control.

  •  The team has published several public resources, such as MousePat, NR Zoo and CreERT2 Zoo, and plans to provide more in the future in order to create new mouse tools for the community.
  •  Jointly with the IGBMC, the team has also developed a strong expertise in statistics and data mining. In-depth analysis performed across studies allows for a better understanding of systems biology and optimized processes.
  •  The team has a strong expertise in collaborations with partners from different origins. It participates actively in European projects, such as EUMODIC, and helps in the design of its database Europhenome, as well as in the set up of the international IMPC program database. Interactions with big pharmaceutical companies have also been successfully established to deliver in time scientific projects. 

ICS resources

Genetic Engineering Mouse Zoo

  • NR Zoo
    • Database of the nuclear receptors and their co-factors developed as mouse conditional knock-out models.
    • These mouse lines are available for academic users under MTA agreement and distribution fees.
  • EUCOMM Lines
    • Generation, archiving, and world-wide distribution of up to 12.000 conditional mutations across the mouse genome in mouse embryonic stem (ES) cells
    • Establishment of a limited number of mouse mutants from this resource
  • PHENOMIN Lines
    • 55 new mouse lines are now available and more are in the process of being generated. Informations regarding the 140 selected genes can be found in the genes table.

CreERT2 Zoo

  • MouseCre
    • Database of more than 50 cell or tissue specific promoters driven CreERT2 transgenic lines.

MousePat

  • MousePat
    • Database providing comprehensive analysis of the Nuclear Receptors (NRs) expression in the adult mouse brain.

FAQs CRISPR Cas9

CRISPR-Cas9 is a rapid and cost effective technology to generate mouse and rat mutant models. Now we can offer the generation of knock-out models though direct injection into fertilized mouse oocytes of CRISPR sgRNA and Cas9 mRNA. This approach allows to obtain models in shorter timelines and with reduced costs compared to gene targeting by homologous recombination in ES cells.

Download the FAQs in PHENOMIN's resources web page

Public resources

Listing established thanks to the great work from the Hopkins Institute

Mouse Pathobiology & Phenotyping Short Course and concurrent ME680.712 SOM Graduate School Course

Find your mice + health surveillance info at :

Charles River (Crl)Harlan (Hsd, Ola)JAX (J)NCI Frederick (N, Cr)Taconic (Tac)

Find GEM at :

ICS ServicesGenowayDeltagen and Lexicon Knockout Mice and Phenotypic Data Jax IMSR (Induced Mutant Strain Resource) KOMP Knockout mouse projectMMRRC

More resources online

ICS ResourcesComplex Trait ConsortiumEdinburgh Mouse Atlas Project (EMAP, EMAGE)MPD (prioritized strains, protocols, data, more)MTB (Mouse Tumor Biology) DatabaseTumor frequency grid

Brain Atlas Projects

High Resolution Mouse Brain AtlasMBL (Mouse Brain Library)

JAX online resources

A Color Atlas of Neoplastic and Non Neoplastic Lesions in Aging Mice Frith & Ward 1988Anatomy of the laboratory mouse - CookThe Coat colors of miceIMSR - Find MiceJAX - ES Cell listMGIMichael Festings list & description of mouse strainsNomenclature home pageMouse Genetics by Lee Silver (1995)

Welfare and reporting guidance

ICS WebsiteWorkman, P., E. O. Aboagye, et al. (2010). "Guidelines for the welfare and use of animals in cancer research."Arrive Guidelines (Animals in Research: Reporting In Vivo Experiments)

More pathology resources

ICS MousePatA Color Atlas of Neoplastic and Non Neoplastic Lesions in Aging Mice - Frith & Ward 1988JOVE (Charles River Laboratories)NIAID Veterinary PathologyNIEHS LEP Clinical PathologyNTP - study results for control DataSkinbase mutant mouse skin pathology UC Davis MMHCC Image ArchiveUC Davis Visible MouseUC Davis Virtual mouse NecropsyUC Davis Genomic Pathology Course Online

Pathology Nomenclature

MMHCC mouse models of human cancer consortiumPathbase European Mutant Mouse Pathology DatabaseToxpathToxpath RENI

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