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Collaborations

Follow ICS

Since its inception, the ICS has long been involved in most important mouse functional genomics programmes funded by the European commission.

These large scale EU programs covered : 

  • the generation of a collection of up to 13000 mutated genes in mouse C57BL/6N embryonic stem (ES) cells, 
  • the use of conditional gene trapping and gene targeting approaches: EUCOMM
  • the primary phenotyping of 500 mouse mutant lines: EUMODIC 
  • and finally the archiving (via cryopreservation) and the distribution of relevant mutant strains essential for basic biomedical research: EMMA.

INFRAFRONTIER I3 project exploited all these emerging ressources to create this current consortium which aims to organize two complementary and linked infrastructure networks for large-scale comprehensive phenotyping and archiving of mouse models serving the European genetics and biomedical research community for the benefit of human health. the ICS stays a major partner in the INFRAFRONTIER I3.

Furthermore, the ICS was or is currently involved in some European projects with a high impact of human public health (Eugene-2, EVGN, GENCODYS, AgedBrainSYSBIO, INTERREG, CanPathPro ...). For this purpose, ICS provides its mouse biology expertise in generating and characterizing various mouse models.

Current implications

PROJECTS

AgedBrainSYSBIO 

System biology of pathways involving brain aging AgedBrainSYSBIO is a research program which combines integrative systems biology and comparative genomics for studying human brain ageing and most common age-related diseases with a special emphasis on LOAD, for identifying and validating new molecular targets and biomarkers. 

AgedBrainSYSBIO

"CanPathPro" consortium

An international group of scientists from 6 countries bring together their expertise to develop a combined experimental and systems biology platform for predictive modelling of cancer signaling. The EU Horizon 2020 funded project, co-ordinated by Alacris Theranostics GmbH, Berlin, will run for 5 years with a budget of almost 11 million euros. PHENOMIN-ICS is involved in the CanPathPro project with respect to the generation of genetically modified mouse models of cancer. CanPathPro brings together the complex molecular data from the "omics" technologies (genomics, transcriptomics and proteomics) that explain the basis of cancers and also reflects their heterogeneity for most, and the mathematical tools of systems biology to visualize and predict signaling pathways for new preclinical, clinical and biotechnology applications. 

A long-term direct benefit for cancer patients.

Read the Press Release 2016

CanPathPro Flyer 2017 (807.0 KB)

CanPathPro

INFRAFRONTIER

The European infrastructure for phenotyping and archiving of model mammmalian genomes INFRAFRONTIER runs the EU-funded projects INFRAFRONTIER-I3 and InfraCoMP and is a key partner in the EU project BioMedBridges and the International Mouse Phenotyping Consortium (IMPC).

INFRAFRONTIER

NETWORKS

EMTRAIN: European Medicines Research Training Network. 

EMTRAIN will establish a pan-European platform for education and training covering the whole lifecycle of medicines from basic research through clinical development to pharmaco-vigilance. The public consortium consists of the six pan-European biomedical research infrastructures from the ESFRI roadmap that cover a broad spectrum of competencies from molecules to humans, with a pan-European dimension. The EFPIA consortium has considerable experience in training and education, management, pan-European geographical outreach, and an extensive external network of contacts.

EMTRAIN: European Medicines Research Training Network.

The INFRAFRONTIER GmbH

The INFRAFRONTIER GmbH was created as a non-profit organization to coordinate the transnational activities of the INFRAFRONTIER Research Infrastructure. It is seated in Germany at the Helmholtz Zentrum München. The establishment of the INFRAFRONTIER GmbH is based on a Memorandum of Understanding signed by Germany, France, Czech Republic, Finland, Greece and the European Molecular Biology Laboratory (EMBL).

The INFRAFRONTIER GmbH was established on 11 April 2013 in Munich. The Managing Directors of the INFRAFRONTIER GmbH are Prof. Martin Hrabé de Angelis and Dr. Daniel Lahne of the Helmholtz Zentrum München. The INFRAFRONTIER Council, the representation of all the INFRAFRONTIER GmbH Members, is chaired by Prof. Yann Hérault, director of the ICS and representative of the CNRS. Prof. Radislav Sedlacek, representative of the Institute of Molecular Genetics, is Vice-Chair of the Council.

INFRAFRONTIER GmbH

INFRAFRONTIER-I3 

To further develop and exploit the emerging mouse mutant resource, mouse models must be preserved and made available to the European biomedical research community. 

To this effect, the EC FP7 funded INFRAFRONTIER-I3 project brings together the European Mouse Mutant Archive (EMMA) network and the leading European centers for systemic phenotyping of mouse mutants. The INFRAFRONTIER-I3 partners aim to meet the future challenges presented by phenotyping, archiving and disseminating mouse models in the European Research Area. The comprehensive physical and data resources that will be generated by INFRAFRONTIER-I3 will contribute to link basic biomedical research to medical applications and thereby drive innovation and support the Europe 2020 Strategy.

Infrafrontier I3

IPAD-MD 

IPAD-MD project (Research Infrastructure for Phenotyping, Arching and Distribution of Mouse Diseases Models) addresses the global cooperation and coordination between INFRAFRONTIER and complementary research infrastructures world-wide, contributing to the global effort of IMPC. 

IPAD-MD focuses on key stakeholder involvement. IPAD-MD has received funding from European Union's Horizon 2020 research and innovation programme under Grant Agreement number 653961 

IPAD-MD

Former implications

EUCOMMTOOLS

EUCOMM Tools for Functional Annotation of the Mouse Genome

EUCOMM Tools

INTERREG IV Rhin supérieur

European regional development fund (ERDF) and European social fund (ESF), also known as structural funds, as part of the economic, social and territorial cohesion policy;
INTERREG IV Rhin superieur

GENCODYS

Genetic and Epigenetic Networks in Cognitive Dysfunction
Gencodys

INFRACoMP

INFRACoMP's main objective is to coordinate collaboration between the INFRAFRONTIER Research Infrastructure and the International Mouse Phenotyping Consortium (IMPC). To this end, INFRACoMP organizes regular workshops that address the central issues that need to be resolved to ensure a fruitful cooperation between the two initiatives that minimizes redundancy, maximizes mutual benefit and leverages the expertise and infrastructure capacity. INFRACoMP is funded by the EC FP7 Capacities Specific Programme, Grant Agreement number 284501.

INFRACoMP

EMMA 

European Mouse Mutant Archive: Archiving and distribution of mouse models

EMMA

EUCOMM

European Conditional Mouse Mutagenesis Program
EUCOMM

EUMODIC

European Mouse Disease Clinic: A distributed phenotyping resource for studying human disease. 
EUMODIC

CREATE

Coordination of resources for conditional expression of mutated mouse alleles

CREATE

CASIMIR 

Coordination and Sustainability of International Mouse Informatics Resources CASIMIR, a coordination action of the 6th Framework Programme of the European Commission, will focus on co-ordination and integration of databases set up in support of FP5 and FP6 projects containing experimental data, including sequences, and material resources such as biological collections, relevant to the use of the mouse as a model organism for human disease. 

CASIMIR

EUGENE2

European Network on Functional Genomics of Type 2 Diabetes
EUGENE2

EVGN 

European Vascular Genomics Network
EVGN

RIGHT

RNA Interference Technology as Human Therapeutic Tool
RIGHT

Eurexpress

A Transcriptome Atlas Database for Mouse Embryo

Eurexpress

EUMORPHIA

Understanding Human Disease through Mouse Genetics

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