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2017


A Fast, Easy, and Customizable Eight-Color Flow Cytometric Method for Analysis of the Cellular Content of Bronchoalveolar Lavage Fluid in the Mouse.

Daubeuf F(1)(2), Becker J(3), Aguilar-Pimentel JA(4), Ebel C(5), Hrabe de Angelis M(4), Herault Y(3)(5)(6)(7)(8), Frossard N(1)(2).
Curr Protoc Mouse Biol 2017 Jun 19;7(2):88-99

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Atp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies.

Wendling O(1), Champy MF(1), Jaubert S(2), Pavlovic G(1), Dubos A(1)(3)(4)(5)(6), Lindner L(1), Jacobs H(1), Mark M(1)(3)(4)(5)(6), Combe R(1), Da Cruz IG(1), Luche H(6), Mudgett JS(7), Rosahl T(7), Sorg T(1), Malissen M(2), Reilly PT(1), Herault Y(8)(9)(10)(11)(12).
Sci Rep 2017 Aug 29;7(1):9618

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Deciphering the Role of Oncogenic MITFE318K in Senescence Delay and Melanoma Progression.

Bonet C(1)(2), Luciani F(3)(4), Ottavi JF(1)(2), Leclerc J(1)(2), Jouenne FM(5), Boncompagni M(1)(2), Bille K(1)(2), Hofman V(2)(6), Bossis G(7), Marco de Donatis G(8), Strub T(9), Cheli Y(1)(2), Ohanna M(1)(2), Luciano F(10), Marchetti S(10), Rocchi S(1)(2), Birling MC(1)(11), Avril MF(12), Poulalhon N(13), Luc T(13), Bertolotto C(1)(2).
J Natl Cancer Inst 2017 Aug 1;109(8):djw340

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Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium.

Meehan TF(1), Conte N(1), West DB(2), Jacobsen JO(3), Mason J(1), Warren J(1), Chen CK(1), Tudose I(1), Relac M(1), Matthews P(1), Karp N(4), Santos L(5), Fiegel T(5), Ring N(5), Westerberg H(5), Greenaway S(5), Sneddon D(5), Morgan H(5), Codner GF(5), Stewart ME(5), Brown J(5), Horner N(5); International Mouse Phenotyping Consortium, Haendel M(6), Washington N(7), Mungall CJ(7), Reynolds CL(8), Gallegos J(8), Gailus-Durner V(9), Sorg T(10)(11)(12)(13), Pavlovic G(10)(11)(12)(13), Bower LR(14), Moore M(15), Morse I(16), Gao X(17), Tocchini-Valentini GP(18), Obata Y(19), Cho SY(20)(21), Seong JK(20)(22), Seavitt J(8), Beaudet AL(8), Dickinson ME(8), Herault Y(10)(11)(12)(13), Wurst W(9), de Angelis MH(9), Lloyd KCK(14), Flenniken AM(23), Nutter LMJ(23), Newbigging S(23), McKerlie C(23), Justice MJ(24), Murray SA(25), Svenson KL(25), Braun RE(25), White JK(4), Bradley A(4), Flicek P(1), Wells S(5), Skarnes WC(4), Adams DJ(4), Parkinson H(1), Mallon AM(5), Brown SDM(5), Smedley D(3).
Nat Genet 2017 Aug;49(8):1231-1238

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Dry ice is a reliable substrate for the distribution of frozen mouse spermatozoa: A multi-centric study.

Raspa M(1), Guan M(2), Paoletti R(3), Montoliu L(4), Ayadi A(5), Marschall S(6); EMMA/Infrafrontier Technical Working Group, Fray M(2), Scavizzi F(7).
Theriogenology 2017 Jul 1;96():49-57

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Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE.

Birling MC(1), Schaeffer L(1), Andre P(1), Lindner L(1), Marechal D(1), Ayadi A(1), Sorg T(1), Pavlovic G(1), Herault Y(1,)(2,)(3,)(4,)(5).
Sci Rep 2017 Mar 7;7():43331

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Fluorescent nanodiamond tracking reveals intraneuronal transport abnormalities induced by brain-disease-related genetic risk factors.

Haziza S(1,)(2), Mohan N(1), Loe-Mie Y(2), Lepagnol-Bestel AM(2), Massou S(1), Adam MP(1), Le XL(1), Viard J(2), Plancon C(3), Daudin R(2), Koebel P(4), Dorard E(2), Rose C(2), Hsieh FJ(5), Wu CC(6), Potier B(2), Herault Y(4), Sala C(7), Corvin A(8), Allinquant B(2), Chang HC(5), Treussart F(1), Simonneau M(1,)(2,)(9).
Nat Nanotechnol 2017 May;12(4):322-328

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Modeling human disease in rodents by CRISPR/Cas9 genome editing.

Birling MC(1), Herault Y(2)(3)(4)(5)(6), Pavlovic G(2).
Mamm Genome 2017 Jul 4

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Mouse models of 17q21.31 microdeletion and microduplication syndromes highlight the importance of Kansl1 for cognition.

Arbogast T(1)(2)(3)(4), Iacono G(5), Chevalier C(1)(2)(3)(4), Afinowi NO(6), Houbaert X(7), van Eede MC(8), Laliberte C(8), Birling MC(9), Linda K(10), Meziane H(9), Selloum M(9), Sorg T(9), Nadif Kasri N(10), Koolen DA(10), Stunnenberg HG(5), Henkelman RM(8), Kopanitsa M(6), Humeau Y(7), De Vries BBA(10), Herault Y(1)(2)(3)(4)(9).
Plos Genet 2017 Jul 13;13(7):e1006886

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Prevalence of sexual dimorphism in mammalian phenotypic traits.

Karp NA(1)(2), Mason J(3), Beaudet AL(4), Benjamini Y(5), Bower L(6), Braun RE(7), Brown SDM(8), Chesler EJ(7), Dickinson ME(9), Flenniken AM(10), Fuchs H(11), Angelis MH(11)(12)(13), Gao X(14), Guo S(14), Greenaway S(8), Heller R(5), Herault Y(15)(16)(17)(18)(19), Justice MJ(20), Kurbatova N(5), Lelliott CJ(21), Lloyd KCK(6), Mallon AM(8), Mank JE(22), Masuya H(23), McKerlie C(10)(24), Meehan TF(3), Mott RF(25), Murray SA(7), Parkinson H(3), Ramirez-Solis R(21), Santos L(8), Seavitt JR(4), Smedley D(26), Sorg T(15)(16)(17)(18)(19), Speak AO(21), Steel KP(21)(27), Svenson KL(7); International Mouse Phenotyping Consortium, Wakana S(23), West D(28), Wells S(8), Westerberg H(8), Yaacoby S(5), White JK(7)(21).
Nat Commun 2017 Jun 26;8():15475

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Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mouse.

Ung DC(1,)(2), Iacono G(3), Meziane H(4), Blanchard E(1,)(5,)(6), Papon MA(1,)(2), Selten M(7), van Rhijn JR(7), Montjean R(8,)(9,)(10,)(11), Rucci J(8,)(9,)(10,)(11), Martin S(12), Fleet A(13), Birling MC(4), Marouillat S(1,)(2), Roepman R(14,)(15), Selloum M(4), Lux A(4), Thepault RA(1,)(2), Hamel P(13), Mittal K(16), Vincent JB(16), Dorseuil O(8,)(9,)(10,)(11), Stunnenberg HG(3), Billuart P(8,)(9,)(10,)(11), Nadif Kasri N(7,)(14), Herault Y(4,)(17,)(18,)(19,)(20), Laumonnier F(1,)(2,)(6).
Mol Psychiatry 2017 Apr 18

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RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.

Elhabazi K(1), Humbert JP(2), Bertin I(3), Quillet R(4), Utard V(5), Schneider S(6), Schmitt M(7), Bourguignon JJ(8), Laboureyras E(9), Ben Boujema M(10), Simonnet G(11), Ancel C(12), Simonneaux V(13), Beltramo M(14), Bucher B(15), Sorg T(16), Meziane H(17), Schneider E(18), Petit-Demouliere B(19), Ilien B(20), Bihel F(21), Simonin F(22).
Neuropharmacology 2017 May 15;118():188-198

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Synaptic dysfunction in amygdala in intellectual disorder models.

Aincy M(1), Meziane H(2), Herault Y(3), Humeau Y(4).
Prog Neuropsychopharmacol Biol Psychiatry 2017 Jul 31

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Translation of Expanded CGG Repeats into FMRpolyG Is Pathogenic and May Contribute to Fragile X Tremor Ataxia Syndrome.

Sellier C(1), Buijsen RA(2), He F(3), Natla S(4), Jung L(5), Tropel P(5), Gaucherot A(5), Jacobs H(6), Meziane H(6), Vincent A(5), Champy MF(6), Sorg T(6), Pavlovic G(6), Wattenhofer-Donze M(6), Birling MC(6), Oulad-Abdelghani M(5), Eberling P(5), Ruffenach F(5), Joint M(5), Anheim M(7), Martinez-Cerdeno V(8), Tassone F(9), Willemsen R(2), Hukema RK(2), Viville S(10), Martinat C(11), Todd PK(12), Charlet-Berguerand N(13).
Neuron 2017 Jan 18;93(2):331-347

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2016


Altered microtubule dynamics and vesicular transport in mouse and human MeCP2-deficient astrocytes.

Delepine C(1), Meziane H(2), Nectoux J(3), Opitz M(1), Smith AB(4), Ballatore C(5), Saillour Y(1), Bennaceur-Griscelli A(6), Chang Q(7), Williams EC(7), Dahan M(8), Duboin A(9), Billuart P(1), Herault Y(2), Bienvenu T(10).
Hum Mol Genet 2016 Jan 1;25(1):146-57

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Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction.

Codner GF(1), Lindner L(2), Caulder A(1), Wattenhofer-Donzé M(2), Radage A(1), Mertz A(2), Eisenmann B(2), Mianné J(2), Evans EP(1), Beechey CV(1), Fray MD(1), Birling MC(2), Hérault Y(2), Pavlovic G(3), Teboul L(4).
Bmc Cell Biol 2016 Aug 5;17(1):30

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Corrigendum: Domains of genome-wide gene expression dysregulation in Down's syndrome.

Letourneau A, Santoni FA, Bonilla X, Sailani MR, Gonzalez D, Kind J, Chevalier C, Thurman R, Sandstrom RS, Hibaoui Y, Garieri M, Popadin K, Falconnet E, Gagnebin M, Gehrig C, Vannier A, Guipponi M, Farinelli L, Robyr D, Migliavacca E, Borel C, Deutsch S, Feki A, Stamatoyannopoulos JA, Herault Y, van Steensel B, Guigo R, Antonarakis SE.
Nature 2016 Mar 17;531(7594):400

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Counterregulation between thymic stromal lymphopoietin- and IL-23-driven immune axes shapes skin inflammation in mice with epidermal barrier defects.

Li J(1), Leyva-Castillo JM(1), Hener P(1), Eisenmann A(1), Zaafouri S(2), Jonca N(2), Serre G(2), Birling MC(3), Li M(4).
J Allergy Clin Immunol 2016 Jul;138(1):150-161

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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome.

Duchon A(1), Herault Y(2).
Front Behav Neurosci 2016 Jun 3;10():104

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E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis.

Goguet-Rubio P(1), Seyran B(1), Gayte L(1), Bernex F(2), Sutter A(1), Delpech H(3), Linares LK(1), Riscal R(1), Repond C(4), Rodier G(3), Kirsh O(5), Touhami J(6), Noel J(7), Vincent C(8), Pirot N(7), Pavlovic G(9), Herault Y(9), Sitbon M(6), Pellerin L(4), Sardet C(3), Lacroix M(10), Le Cam L(10).
Proc Natl Acad Sci U S A 2016 Sep 27;113(39):11004-9

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Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

Shatirishvili M(1), Burk AS(2), Franz CM(3), Pace G(1), Kastilan T(1), Breuhahn K(4), Hinterseer E(5), Dierich A(6), Bakiri L(7), Wagner EF(7), Ponta H(1), Hartmann TN(5), Tanaka M(2,)(8), Orian-Rousseau V(1).
Cell Death Dis 2016 Nov 10;7(11):e2461

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Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.

Meziane H(1), Khelfaoui M(2), Morello N(3), Hiba B(4), Calcagno E(3), Reibel-Foisset S(5), Selloum M(1), Chelly J(6), Humeau Y(7), Riet F(1), Zanni G(8), Herault Y(1), Bienvenu T(9), Giustetto M(3), Billuart P(10).
Hum Mol Genet 2016 Jun 1;25(11):2314-2323

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High-throughput discovery of novel developmental phenotypes.

Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A; International Mouse Phenotyping Consortium; Jackson Laboratory; Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource Center, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA.
Nature 2016 Sep 22;537(7621):508-514

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How Does Circadian Rhythm Impact Salt Sensitivity of Blood Pressure in Mice? A Study in Two Close C57Bl/6 Substrains.

Combe R(1), Mudgett J(2), El Fertak L(1), Champy MF(1), Ayme-Dietrich E(3), Petit-Demoulière B(1), Sorg T(1), Herault Y(1), Madwed JB(2), Monassier L(1,)(3).
Plos One 2016 Apr 18;11(4):e0153472

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Lymphopoiesis in transgenic mice over-expressing Artemis.

Rivera-Munoz P(1,)(2), Abramowski V(1,)(2), Jacquot S(3), André P(3), Charrier S(4), Lipson-Ruffert K(5), Fischer A(2,)(6,)(7), Galy A(4), Cavazzana M(2,)(6), de Villartay JP(1,)(2).
Gene Ther 2016 Feb;23(2):176-86

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Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice.

Wu T(1,)(2,)(3), Heuillard E(1,)(2,)(4), Lindner V(5), Bou About G(6), Ignat M(7,)(8), Dillenseger JP(2,)(9,)(10,)(11), Anton N(2,)(12), Dalimier E(13), Gossé F(1,)(2), Fouré G(4), Blindauer F(4), Giraudeau C(4), El-Saghire H(1,)(2), Bouhadjar M(4), Calligaro C(4), Sorg T(6), Choquet P(2,)(9,)(10,)(11), Vandamme T(2,)(12), Ferrand C(14,)(15,)(16), Marescaux J(4,)(7,)(8), Baumert TF(1,)(2,)(4,)(7), Diana M(4,)(8), Pessaux P(1,)(2,)(4,)(7,)(8), Robinet E(1,)(2,)(4).
Sci Rep 2016 Oct 14;6():35230

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Physiological Expression of AMPKgamma2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.

Yang X(1), Mudgett J(2), Bou-About G(3), Champy MF(3), Jacobs H(3), Monassier L(4), Pavlovic G(3), Sorg T(3), Herault Y(3), Petit-Demouliere B(3), Lu K(1), Feng W(1), Wang H(5), Ma LJ(1), Askew R(2), Erion MD(1), Kelley DE(1), Myers RW(1), Li C(1), Guan HP(6).
J Biol Chem 2016 Nov 4;291(45):23428-23439

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Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes.

Arbogast T(1,)(2,)(3,)(4), Ouagazzal AM(1,)(2,)(3,)(4), Chevalier C(1,)(2,)(3,)(4), Kopanitsa M(5), Afinowi N(5), Migliavacca E(6,)(7), Cowling BS(1,)(2,)(3,)(4), Birling MC(8), Champy MF(8), Reymond A(6), Herault Y(1,)(2,)(3,)(4,)(8).
Plos Genet 2016 Feb 12;12(2):e1005709

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Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism.

Lakisic G(1), Lebreton A(2,)(3,)(4), Pourpre R(1), Wendling O(5), Libertini E(6), Radford EJ(7,)(8), Le Guillou M(9), Champy MF(5), Wattenhofer-Donze M(5), Soubigou G(6), Ait-Si-Ali S(10), Feunteun J(9), Sorg T(5), Coppee JY(6), Ferguson-Smith AC(7), Cossart P(2,)(3,)(4), Bierne H(1).
Plos Genet 2016 Mar 3;12(3):e1005898

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The cell proliferation antigen Ki-67 organises heterochromatin.

Sobecki M(1)(2), Mrouj K(1)(2), Camasses A(1)(2), Parisis N(1)(2), Nicolas E(3), Lleres D(1)(2), Gerbe F(2)(4)(5), Prieto S(1)(2), Krasinska L(1)(2), David A(2)(4)(5), Eguren M(6), Birling MC(7), Urbach S(2)(4)(5)(8), Hem S(9), Dejardin J(2)(10), Malumbres M(6), Jay P(2)(4)(5), Dulic V(1)(2), Lafontaine DLj(3), Feil R(1)(2), Fisher D(1)(2).
Elife 2016 Mar 7;5():e13722

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Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss.

Scekic-Zahirovic J(1), Sendscheid O(2), El Oussini H(1), Jambeau M(3), Sun Y(3), Mersmann S(2), Wagner M(2), Dieterlé S(1), Sinniger J(1), Dirrig-Grosch S(1), Drenner K(3), Birling MC(4), Qiu J(5), Zhou Y(5), Li H(5), Fu XD(5), Rouaux C(1), Shelkovnikova T(6), Witting A(7), Ludolph AC(7), Kiefer F(8), Storkebaum E(9), Lagier-Tourenne C(10), Dupuis L(11).
Embo J 2016 Mar 7;35(10):1077-1097

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2015


A mu-delta opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks.

Erbs E(1), Faget L, Scherrer G, Matifas A, Filliol D, Vonesch JL, Koch M, Kessler P, Hentsch D, Birling MC, Koutsourakis M, Vasseur L, Veinante P, Kieffer BL, Massotte D.
Brain Struct Funct 2015 Mar;220(2):677-702

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An Early Postnatal Oxytocin Treatment Prevents Social and Learning Deficits in Adult Mice Deficient for Magel2, a Gene Involved in Prader-Willi Syndrome and Autism.

Meziane H(1), Schaller F(2), Bauer S(2), Villard C(3), Matarazzo V(2), Riet F(1), Guillon G(4), Lafitte D(3), Desarmenien MG(4), Tauber M(5), Muscatelli F(6).
Biol Psychiatry 2015 Jul 15;78(2):85-94

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Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.

Hrabe de Angelis M, Nicholson G, Selloum M, White JK, Morgan H, Ramirez-Solis R, Sorg T, Wells S, Fuchs H, Fray M, Adams DJ, Adams NC, Adler T, Aguilar-Pimentel A, Ali-Hadji D, Amann G, AndrE P, Atkins S, Auburtin A, Ayadi A, Becker J, Becker L, Bedu E, Bekeredjian R, Birling MC, Blake A, Bottomley J, Bowl MR, Brault V, Busch DH, Bussell JN, Calzada-Wack J, Cater H, Champy MF, Charles P, Chevalier C, Chiani F, Codner GF, Combe R, Cox R, Dalloneau E, Dierich A, Di Fenza A, Doe B, Duchon A, Eickelberg O, Esapa CT, Fertak LE, Feigel T, Emelyanova I, Estabel J, Favor J, Flenniken A, Gambadoro A, Garrett L, Gates H, Gerdin AK, Gkoutos G, Greenaway S, Glasl L, Goetz P, Da Cruz IG, Gotz A, Graw J, Guimond A, Hans W, Hicks G, Holter SM, Hofler H, Hancock JM, Hoehndorf R, Hough T, Houghton R, Hurt A, Ivandic B, Jacobs H, Jacquot S, Jones N, Karp NA, Katus HA, Kitchen S, Klein-Rodewald T, Klingenspor M, Klopstock T, Lalanne V, Leblanc S, Lengger C, le Marchand E, Ludwig T, Lux A, McKerlie C, Maier H, Mandel JL, Marschall S, Mark M, Melvin DG, Meziane H, Micklich K, Mittelhauser C, Monassier L, Moulaert D, Muller S, Naton B, Neff F, Nolan PM, Nutter LM, Ollert M, Pavlovic G, Pellegata NS, Peter E, Petit-Demouliere B, Pickard A, Podrini C, Potter P, Pouilly L, Puk O, Richardson D, Rousseau S, Quintanilla-Fend L, Quwailid MM, Racz I, Rathkolb B, Riet F, Rossant J, Roux M, Rozman J, Ryder E, Salisbury J, Santos L, Schable KH, Schiller E, Schrewe A, Schulz H, Steinkamp R, Simon M, Stewart M, Stoger C, Stoger T, Sun M, Sunter D, Teboul L, Tilly I, Tocchini-Valentini GP, Tost M, Treise I, Vasseur L, Velot E, Vogt-Weisenhorn D, Wagner C, Walling A, Wattenhofer-Donze M, Weber B, Wendling O, Westerberg H, Willershauser M, Wolf E, Wolter A, Wood J, Wurst W, Yildirim AO, Zeh R, Zimmer A, Zimprich A; EUMODIC Consortium, Holmes C, Steel KP, Herault Y, Gailus-Durner V, Mallon AM, Brown SD.
Nat Genet 2015 Sep;47(9):969-78

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Applying the ARRIVE Guidelines to an In Vivo Database.

Karp NA(1), Meehan TF(2), Morgan H(3), Mason JC(2), Blake A(3), Kurbatova N(2), Smedley D(1), Jacobsen J(1), Mott RF(4), Iyer V(5), Matthews P(5), Melvin DG(1), Wells S(3), Flenniken AM(6), Masuya H(7), Wakana S(7), White JK(8), Lloyd KC(9), Reynolds CL(10), Paylor R(11), West DB(12), Svenson KL(13), Chesler EJ(13), de Angelis MH(14), Tocchini-Valentini GP(15), Sorg T(16), Herault Y(16), Parkinson H(2), Mallon AM(3), Brown SD(3).
Plos Biol 2015 May 20;13(5):e1002151

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Blastocyst genotyping for quality control of mouse mutant archives: an ethical and economical approach.

Scavizzi F(1), Ryder E(2), Newman S(2), Raspa M(1), Gleeson D(2), Wardle-Jones H(2), Montoliu L(3,)(4), Fernandez A(3,)(4), Dessain ML(5), Larrigaldie V(5), Khorshidi Z(6), Vuolteenaho R(7), Soininen R(7), André P(8), Jacquot S(8), Hong Y(9), de Angelis MH(9), Ramirez-Solis R(2), Doe B(10).
Transgenic Res 2015 Oct;24(5):921-7

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Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.

Dubos A(1), Castells-Nobau A(2), Meziane H(3), Oortveld MA(2), Houbaert X(4), Iacono G(5), Martin C(4), Mittelhaeuser C(3), Lalanne V(3), Kramer JM(2), Bhukel A(6), Quentin C(7), Slabbert J(8), Verstreken P(8), Sigrist SJ(7), Messaddeq N(9), Birling MC(3), Selloum M(3), Stunnenberg HG(5), Humeau Y(4), Schenck A(10), Herault Y(11).
Hum Mol Genet 2015 Dec 1;24(23):6736-55

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Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats.

Ayme-Dietrich E(1), Marzak H, Lawson R, Mokni W, Wendling O, Combe R, Becker J, El Fertak L, Champy MF, Matz R, Andriantsitohaina R, Doly S, Boutourlinsky K, Maroteaux L, Monassier L.
J Hypertens 2015 Nov;33(11):2310-21

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Deletion of the App-Runx1 region in mice models human partial monosomy 21.

Arbogast T(1), Raveau M(1), Chevalier C(1), Nalesso V(1), Dembele D(1), Jacobs H(2), Wendling O(2), Roux M(3), Duchon A(1), Herault Y(4).
Dis Model Mech 2015 Jun;8(6):623-34

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INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community.

INFRAFRONTIER Consortium.
Nucleic Acids Res 2015 Jan;43(database issue):D1171–D1175

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LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2.

Hussein MA(1), Shrestha E(1), Ouimet M(2), Barrett TJ(2), Leone S(1), Moore KJ(2), Herault Y(3), Fisher EA(2), Garabedian MJ(1).
Plos One 2015 Aug 19;10(8):e0135218

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Opposite phenotypes of muscle strength and locomotor function in mouse models of partial trisomy and monosomy 21 for the proximal Hspa13-App region.

Brault V(1), Duchon A(1), Romestaing C(2), Sahun I(3), Pothion S(4), Karout M(1), Borel C(5), Dembele D(1), Bizot JC(6), Messaddeq N(1), Sharp AJ(7), Roussel D(2), Antonarakis SE(8), Dierssen M(3), Herault Y(9).
Plos Genet 2015 Mar 24;11(3):e1005062

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Principles and application of LIMS in mouse clinics.

Maier H(1), Schutt C(2), Steinkamp R(2), Hurt A(2), Schneltzer E(2), Gormanns P(2), Lengger C(2), Griffiths M(3), Melvin D(3), Agrawal N(3), Alcantara R(3), Evans A(3), Gannon D(3), Holroyd S(3), Kipp C(3), Raj NP(3), Richardson D(3), LeBlanc S(4), Vasseur L(4), Masuya H(5), Kobayashi K(5), Suzuki T(5), Tanaka N(5), Wakana S(5), Walling A(6), Clary D(7), Gallegos J(8), Fuchs H(2), de Angelis MH(9,)(10,)(11), Gailus-Durner V(2).
Mamm Genome 2015 Oct;26(9-10):467-81

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Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome.

Mukherji A(1), Kobiita A(1), Damara M(1), Misra N(1), Meziane H(2), Champy MF(2), Chambon P(3).
Proc Natl Acad Sci U S A 2015 Dec 1;112(48):E6691-8

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2014


Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome.

Mouton-Liger F(1), Sahún I(2), Collin T(3), Lopes Pereira P(4), Masini D(2), Thomas S(1), Paly E(1), Luilier S(5), Même S(6), Jouhault Q(1), Bennaï S(1), Beloeil JC(6), Bizot JC(5), Hérault Y(7), Dierssen M(2), Créau N(8).
Neurobiol Dis 2014 Mar;63():92-106

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Generation and Use of Transgenic Mice in Drug Discovery

Guillaume Pavlovic, Véronique Brault, Tania Sorg andYann Hérault
Methods And Principles In Medicinal Chemistry: In Vivo Models For Drug Discovery 2014 11 AUG 2014;62(part 6):131-148

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Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice.

Lopez-Delisle L(1), Pierre-Eugène C, Bloch-Gallego E, Birling MC, Duband JL, Durand E, Bourgeois T, Matrot B, Sorg T, Huerre M, Meziane H, Roux MJ, Champy MF, Gallego J, Delattre O, Janoueix-Lerosey I.
Oncotarget 2014 May 15;5(9):2703-13

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Impact of temporal variation on design and analysis of mouse knockout phenotyping studies.

Karp NA(1), Speak AO(1), White JK(1), Adams DJ(1), Hrabé de Angelis M(2), Hérault Y(3), Mott RF(4).
Plos One 2014 Oct 24;9(10):e111239

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Impact of the apolipoprotein E polymorphism, age and sex on neurogenesis in mice: Pathophysiological relevance for Alzheimer's disease?

Koutseff A, Mittelhaeuser C, Essabri K, Auwerx J, Meziane H.
Brain Res 2014 Jan 13;1542():32-40

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In Vivo 9.4T MRI and1H MRS for Evaluation of Brain Structural and Metabolic Changes in the Ts65Dn Mouse Model for Down Syndrome

S. Même1*, N. Joudiou1, N. Yousfi1, F. Szeremeta1, P. Lopes-Pereira2, J. C. Beloeil1, Y. Herault2,3,4, W. Même1
World Journal Of Neuroscience 2014 2014;4():152-163

Old spontaneously hypertensive rats gather together typical features of human chronic left-ventricular dysfunction with preserved ejection fraction.

Marzak H(1), Ayme-Dietrich E, Lawson R, Mokni W, Combe R, Becker J, Fertak LE, Champy MF, Monassier L.
J Hypertens 2014 Jun;32(6):1307-16

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Proteomic survey reveals altered energetic patterns and metabolic failure prior to retinal degeneration.

Griciuc A(1), Roux MJ, Merl J, Giangrande A, Hauck SM, Aron L, Ueffing M.
J Neurosci 2014 Feb 19;34(8):2797-812

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Regulator of G-protein signaling 18 controls both platelet generation and function.

Delesque-Touchard N(1), Pendaries C(1), Volle-Challier C(1), Millet L(1), Salel V(1), Hervé C(1), Pflieger AM(1), Berthou-Soulie L(2), Prades C(2), Sorg T(3), Herbert JM(1), Savi P(1), Bono F(1).
Plos One 2014 Nov 18;9(11):e113215

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Rfx6 maintains the functional identity of adult pancreatic beta cells.

Piccand J(1), Strasser P(1), Hodson DJ(2), Meunier A(1), Ye T(1), Keime C(1), Birling MC(3), Rutter GA(2), Gradwohl G(4).
Cell Rep 2014 Dec 24;9(6):2219-32

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Skin progenitor cells contribute to bleomycin-induced skin fibrosis.

Liu S(1), Herault Y, Pavlovic G, Leask A.
Arthritis Rheumatol 2014 Mar;66(3):707-13

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Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy.

Clar J(1), Gri B(1), Calderaro J(2), Birling MC(3), Hérault Y(3), Smit GP(4), Mithieux G(1), Rajas F(1).
Kidney Int 2014 Oct;86(4):747-56

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2013


A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.

Simon MM, Greenaway S, White JK, Fuchs H, Gailus-Durner V, Wells S, Sorg T, Wong K, Bedu E, Cartwright EJ, Dacquin R, Djebali S, Estabel J, Graw J, Ingham NJ, Jackson IJ, Lengeling A, Mandillo S, Marvel J, Meziane H, Preitner F, Puk O, Roux M, Adams DJ, Atkins S, Ayadi A, Becker L, Blake A, Brooker D, Cater H, Champy MF, Combe R, Danecek P, di Fenza A, Gates H, Gerdin AK, Golini E, Hancock JM, Hans W, Holter SM, Hough T, Jurdic P, Keane TM, Morgan H, Muller W, Neff F, Nicholson G, Pasche B, Roberson LA, Rozman J, Sanderson M, Santos L, Selloum M, Shannon C, Southwell A, Tocchini-Valentini GP, Vancollie VE, Westerberg H, Wurst W, Zi M, Yalcin B, Ramirez-Solis R, Steel KP, Mallon AM, de Angelis MH, Herault Y, Brown SD.
Genome Biol 2013 Jul 31;14(7):R82

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A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation.

Kolotuev I(1), Hyenne V, Schwab Y, Rodriguez D, Labouesse M.
Nat Cell Biol 2013 Feb;15(2):157-68

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Distinct fibroblast lineages determine dermal architecture in skin development and repair.

Driskell RR(1), Lichtenberger BM(2), Hoste E(3), Kretzschmar K(2), Simons BD(4), Charalambous M(5), Ferron SR(5), Herault Y(6), Pavlovic G(6), Ferguson-Smith AC(5), Watt FM(7).
Nature 2013 Dec 12;504(7479):277-81

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Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors.

Elhabazi K, Humbert JP, Bertin I, Schmitt M, Bihel F, Bourguignon JJ, Bucher B, Becker JA, Sorg T, Meziane H, Petit-Demoulière B, Ilien B, Simonin F.
Neuropharmacology 2013 Aug 2;75C():164-171

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FELASA guidelines for the refinement of methods for genotyping genetically-modified rodents: a report of the Federation of European Laboratory Animal Science Associations Working Group.

Bonaparte D(1), Cinelli P, Douni E, Hérault Y, Maas M, Pakarinen P, Poutanen M, Lafuente MS, Scavizzi F; Federation of European Laboratory Animal Science Associations Working Group.
Lab Anim 2013 Jul;47(3):134-45

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Repression of Osteoblast Maturation by ERR Accounts for Bone Loss Induced by Estrogen Deficiency.

Gallet M, Saïdi S, Haÿ E, Photsavang J, Marty C, Sailland J, Carnesecchi J, Tribollet V, Barenton B, Forcet C, Birling MC, Sorg T, Chassande O, Cohen-Solal M, Vanacker JM.
Plos One 2013 ;8(1):e54837

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Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media.

Bhutta MF, Cheeseman MT, Herault Y, Yu YE, Brown SD.
Mamm Genome 2013 Dec;24(11-12):439-45

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The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord.

Meziane H, Fraulob V, Riet F, Krezel W, Selloum M, Geffarth M, Acampora D, Hérault Y, Simeone A, Brand M, Dollé P, Rhinn M.
Peerj 2013 Aug 29;1():e142

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The STRA6 Receptor Is Essential for Retinol-binding Protein-induced Insulin Resistance but Not for Maintaining Vitamin A Homeostasis in Tissues Other Than the Eye.

Berry DC, Jacobs H, Marwarha G, Gely-Pernot A, O'Byrne SM, Desantis D, Klopfenstein M, Feret B, Dennefeld C, Blaner WS, Croniger CM, Mark M, Noy N, Ghyselinck NB.
J Biol Chem 2013 Aug 23;288(34):24528-39

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2012


Absence of TI-VAMP/Vamp7 leads to increased anxiety in mice.

Danglot L, Zylbersztejn K, Petkovic M, Gauberti M, Meziane H, Combe R, Champy MF, Birling MC, Pavlovic G, Bizot JC, Trovero F, Della Ragione F, Proux-Gillardeaux V, Sorg T, Vivien D, D'Esposito M, Galli T.
J Neurosci 2012 Feb 8;32(6):1962-8

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Acoustic Startle Reflex and Prepulse Inhibition.

Ouagazzal AM(1), Meziane H(2).
Curr Protoc Mouse Biol 2012 Mar 1;2(1):25-35

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Activation of nociceptin/orphanin FQ peptide receptors disrupts visual but not auditory sensorimotor gating in BALB/cByJ mice: comparison to dopamine receptor agonists.

Ces A, Reiss D, Walter O, Wichmann J, Prinssen EP, Kieffer BL, Ouagazzal AM.
Neuropsychopharmacology 2012 Jan;37(2):378-89

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Estrogen dependent activation function of ER is essential for the sexual behavior of mouse females.

Antal MC, Petit-Demoulière B, Meziane H, Chambon P, Krust A.
Proc Natl Acad Sci U S A 2012 Nov 27;109(48):19822-7

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Highly-efficient, fluorescent, locus directed cre and FlpO deleter mice on a pure C57BL/6N genetic background.

Birling MC, Dierich A, Jacquot S, Hérault Y, Pavlovic G.
Genesis 2012 Jun;50(6):482-9

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Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.

Elhabazi K, Trigo JM, Mollereau C, Moulédous L, Zajac JM, Bihel F, Schmitt M, Bourguignon JJ, Meziane H, Petit-demoulière B, Bockel F, Maldonado R, Simonin F.
Br J Pharmacol 2012 Jan;165(2):424-35

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Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.

Ayadi A, Birling MC, Bottomley J, Bussell J, Fuchs H, Fray M, Gailus-Durner V, Greenaway S, Houghton R, Karp N, Leblanc S, Lengger C, Maier H, Mallon AM, Marschall S, Melvin D, Morgan H, Pavlovic G, Ryder E, Skarnes WC, Selloum M, Ramirez-Solis R, Sorg T, Teboul L, Vasseur L, Walling A, Weaver T, Wells S, White JK, Bradley A, Adams DJ, Steel KP, Hrab? de Angelis M, Brown SD, Herault Y.
Mamm Genome 2012 Oct;23(9-10):600-10

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Targeted ultramicrotomy: a valuable tool for correlated light and electron microscopy of small model organisms.

Kolotuev I(1), Bumbarger DJ, Labouesse M, Schwab Y.
Methods Cell Biol 2012 ;111():203-22

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The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.

Raveau M(1), Lignon JM, Nalesso V, Duchon A, Groner Y, Sharp AJ, Dembele D, Brault V, Herault Y.
Plos Genet 2012 May;8(5):e1002724

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The mammalian gene function resource: the International Knockout Mouse Consortium.

Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W.
Mamm Genome 2012 Oct;23(9-10):580-6

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The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.

Glasco DM(1), Sittaramane V, Bryant W, Fritzsch B, Sawant A, Paudyal A, Stewart M, Andre P, Cadete Vilhais-Neto G, Yang Y, Song MR, Murdoch JN, Chandrasekhar A.
Dev Biol 2012 Sep 15;369(2):211-22

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2011


Characterization and Validation of Cre-Driver Mouse Lines

Gofflot F, Wendling O, Chartoire N, Birling MC, Warot X, Auwerx J
Curr. Protoc. Mouse Biol. 2011 March, 2011;1():1-15

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Chronic Treatment with a Promnesiant GABA-A 5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model.

Braudeau J, Dauphinot L, Duchon A, Loistron A, Dodd RH, Hérault Y, Delatour B, Potier MC.
Adv Pharmacol Sci 2011 ;2011():153218

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Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma.

Deschamps K, Cromlish W, Weicker S, Lamontagne S, Huszar SL, Gauthier JY, Mudgett JS, Guimond A, Romand R, Frossard N, Percival MD, Slipetz D, Tan CM.
Am J Respir Cell Mol Biol 2011 Jul;45(1):81-7

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Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment.

Rhinn M, Schuhbaur B, Niederreither K, Dollé P.
Proc Natl Acad Sci U S A 2011 Oct 4;108(40):16687-92

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Mouse Breeding and Colony Management

Ayadi A, Ferrand G, Goncalves da Cruz I, Warot X
Curr. Protoc. Mouse Biol. 2011 March, 2011;1():239?264

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PTBP1 Is Required for Embryonic Development before Gastrulation

Suckale J., Wendling O., Masjkur J., Jager M., Munster C., Anastassiadis K., Stewart A.F., Solimena M.
Plos One 2011 ;6(2):e16992

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Reduced body weight in male Tspan8-deficient mice.

Champy MF, Le Voci L, Selloum M, Peterson LB, Cumiskey AM, Blom D.
Int J Obes (Lond) 2011 Apr;35(4):605-17

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Standardized Post-Mortem Examination and Fixation Procedures for Mutant and Treated Mice

Antal M.C., muller S., Wendling O, Herault Y, Mark M.
Current Protocols In Mouse Biology 2011 ;1():1-38

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TASK-3 as a potential antidepressant target.

Gotter AL, Santarelli VP, Doran SM, Tannenbaum PL, Kraus RL, Rosahl TW, Meziane H, Montial M, Reiss DR, Wessner K, McCampbell A, Stevens J, Brunner JI, Fox SV, Uebele VN, Bayliss DA, Winrow CJ, Renger JJ.
Brain Res 2011 Oct 6;1416():69-79

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The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome

Duchon A., Pothion S., Brault V., Sharp A.J., Tybulewicz V.L., Fisher E.M., Herault Y.
Behav Brain Res 2011 Mar 1;217(2):271-81

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TIF1beta association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis

Herzog M., Wendling O., Guillou F., Chambon P., Mark M., Losson R., Cammas F.
Dev Biol 2011 Feb 15;350(2):548-58

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2010


Active multilayered capsules for in vivo bone formation

Facca S., Cortez C., Mendoza-Palomares C., Messadeq N., Dierich A., Johnston A.P., Mainard D., Voegel J.C., Caruso F., Benkirane-Jessel N.
Proc Natl Acad Sci U S A 2010 Feb 23;107(8):3406-11

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Altered lipoprotein metabolism in P2Y(13) knockout mice

Blom D., Yamin T.T., Champy M.F., Selloum M., Bedu E., Carballo-Jane E., Gerckens L., Luell S., Meurer R., Chin J., Mudgett J., Puig O.
Biochim Biophys Acta 2010 Dec;1801(12):1349-60

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beta-Endorphin expression in the mouse retina

Gallagher S.K., Witkovsky P., Roux M.J., Low M.J., Otero-Corchon V., Hentges S.T., Vigh J.
J Comp Neurol 2010 Aug 1;518(15):3130-48

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Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin

Monassier L., Laplante M.A., Ayadi T., Doly S., Maroteaux L.
Pharmacol Ther 2010 Dec;128(3):559-67

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Down Syndrome: From Understanding the Neurobiology to Therapy

Gardiner K., Herault Y., Lott I.T., Antonarakis S.E., Reeves R.H., Dierssen M.
J Neurosci 2010 Nov 10;30(45):14943-14945

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Enterovirus-related activation of the cardiomyocyte mitochondrial apoptotic pathway in patients with acute myocarditis.

Ventéo L, Bourlet T, Renois F, Douche-Aourik F, Mosnier JF, Maison GL, Pluot M, Pozzetto B, Andreoletti L.
Eur Heart J 2010 Mar;31(6):728-36

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EuroPhenome: a repository for high-throughput mouse phenotyping data

Morgan H., Beck T., Blake A., Gates H., Adams N., Debouzy G., Leblanc S., Lengger C., Maier H., Melvin D., Meziane H., Richardson D., Wells S., White J., Wood J., de Angelis M.H., Brown S.D., Hancock J.M., Mallon A.M.
Nucleic Acids Res 2010 Jan;38(Database issue):D577-85

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Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse f2 intercross

Derry J.M., Zhong H., Molony C., Macneil D., Guhathakurta D., Zhang B., Mudgett J., Small K., El Fertak L., Guimond A., Selloum M., Zhao W., Champy M.F., Monassier L., Vogt T., Cully D., Kasarskis A., Schadt E.E.
Plos One 2010 ;5(12):e14319

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Murine neonatal infection provides an efficient model for congenital ocular toxoplasmosis

Lahmar I., Guinard M., Sauer A., Marcellin L., Abdelrahman T., Roux M., Mousli M., Moussa A., Babba H., Pfaff A.W., Candolfi E.
Exp Parasitol 2010 Feb;124(2):190-6

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Mutations in lama1 disrupt retinal vascular development and inner limiting membrane formation

Edwards M.M., Mammadova-Bach E., Alpy F., Klein A., Hicks W.L., Roux M., Simon-Assmann P., Smith R.S., Orend G., Wu J., Peachey N.S., Naggert J.K., Lefebvre O., Nishina P.M.
J Biol Chem 2010 Mar 5;285(10):7697-711

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Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.

Marty C, Lacout C, Martin A, Hasan S, Jacquot S, Birling MC, Vainchenker W, Villeval JL.
Blood 2010 Aug 5;116(5):783-7

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Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo

Morsut L., Yan K.P., Enzo E., Aragona M., Soligo S.M., Wendling O., Mark M., Khetchoumian K., Bressan G., Chambon P., Dupont S., Losson R., Piccolo S.
Development 2010 Aug 1;137(15):2571-8

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Oxidative stress in skeletal muscle stimulates early expression of Rad in a mouse model of amyotrophic lateral sclerosis.

Halter B, Gonzalez de Aguilar JL, Rene F, Petri S, Fricker B, Echaniz-Laguna A, Dupuis L, Larmet Y, Loeffler JP.
Free Radic Biol Med 2010 Apr 1;48(7):915-23

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PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.

Liu M, Wu G, Baysarowich J, Kavana M, Addona GH, Bierilo KK, Mudgett JS, Pavlovic G, Sitlani A, Renger JJ, Hubbard BK, Fisher TS, Zerbinatti CV.
J Lipid Res 2010 Sep;51(9):2611-8

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Retinoic acid receptor (RAR)-alpha is not critically required for mediating retinoic acid effects in the developing mouse retina

Cammas L., Trensz F., Jellali A., Ghyselinck N.B., Roux M.J., Dolle P.
Invest Ophthalmol Vis Sci 2010 Jun;51(6):3281-90

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The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms.

Feige JN, Gerber A, Casals-Casas C, Yang Q, Winkler C, Bedu E, Bueno M, Gelman L, Auwerx J, Gonzalez FJ, Desvergne B.
Environ Health Perspect 2010 Feb;118(2):234-41

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2009


A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP.

Meng X, Leyva ML, Jenny M, Gross I, Benosman S, Fricker B, Harlepp S, Hébraud P, Boos A, Wlosik P, Bischoff P, Sirlin C, Pfeffer M, Loeffler JP, Gaiddon C.
Cancer Res 2009 Jul 1;69(13):5458-66

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Brain structures implicated in the four-plate test in naive and experienced Swiss mice using injection of diazepam and the 5-HT2A agonist DOI.

Petit-Demoulière B, Massé F, Cogrel N, Hascoët M, Bourin M.
Behav Brain Res 2009 Dec 1;204(1):200-5

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Efficient temporally-controlled targeted mutagenesis in smooth muscle cells of the adult mouse

Wendling O., Bornert J.M., Chambon P., Metzger D.
Genesis 2009 Oct 21;47(1):14-18

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Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.

Koutnikova H, Laakso M, Lu L, Combe R, Paananen J, Kuulasmaa T, Kuusisto J, Häring HU, Hansen T, Pedersen O, Smith U, Hanefeld M, Williams RW, Auwerx J.
Plos Genet 2009 Aug;5(8):e1000591

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Ppargamma2 is a key driver of longevity in the mouse

Argmann C., Dobrin R., Heikkinen S., Auburtin A., Pouilly L., Cock T.A., Koutnikova H., Zhu J., Schadt E.E., Auwerx J.
Plos Genet 2009 Dec;5(12):e1000752

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Site-specific recombinases for manipulation of the mouse genome

Birling M.C., Gofflot F., Warot X.
Methods Mol Biol 2009 ;561():245-63

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The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling

Kolthur-Seetharam U., Teerds K., Rooij D.G., Wendling O., McBurney M., Sassone-Corsi P., Davidson I.
Biol Reprod 2009 Feb;80(2):384-91

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The Pro12Ala PPARgamma2 Variant Determines Metabolism at the Gene-Environment Interface

Heikkinen S., Argmann C., Feige J.N., Koutnikova H., Champy M.F., Dali-Youcef N., Schadt E.E., Laakso M., Auwerx J.
Cell Metab 2009 Jan 7;9(1):88-98

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2008


Anxiolytic-like effects of DOI microinjections into the hippocampus (but not the amygdala nor the PAG) in the mice four plates test.

Masse F, Petit-Demouliere B, Dubois I, Hascoët M, Bourin M.
Behav Brain Res 2008 Apr 9;188(2):291-7

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Evaluation tools and animal models of peripheral neuropathies.

Fricker B, Muller A, René F.
Neurodegener Dis 2008 ;5(2):72-108

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Factors triggering abolishment of benzodiazepines effects in the Four-Plate Test--retest in mice.

Petit-Demoulière B, Hascoët M, Bourin M.
Eur Neuropsychopharmacol 2008 Jan;18(1):41-7

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Genetic background determines metabolic phenotypes in the mouse

Champy M.F., Selloum M., Zeitler V., Caradec C., Jung B., Rousseau S., Pouilly L., Sorg T., Auwerx J.
Mamm Genome 2008 May;19(5):318-31

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Nociceptin receptor impairs recognition memory via interaction with NMDA receptor-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in the hippocampus

Goeldner C., Reiss D., Wichmann J., Meziane H., Kieffer B.L., Ouagazzal A.M.
J Neurosci 2008 Feb 27;28(9):2190-8

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Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study

Mandillo S., Tucci V., Holter S.M., Meziane H., Banchaabouchi M.A., Kallnik M., Lad H.V., Nolan P.M., Ouagazzal A.M., Coghill E.L., Gale K., Golini E., Jacquot S., Krezel W., Parker A., Riet F., Schneider I., Marazziti D., Auwerx J., Brown S.D., Chambon P., Rosenthal N., Tocchini-Valentini G., Wurst W.
Physiol Genomics 2008 Aug 15;34(3):243-55

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The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}

Coste A., Louet J.F., Lagouge M., Lerin C., Antal M.C., Meziane H., Schoonjans K., Puigserver P., O'Malley B.W., Auwerx J.
Proc Natl Acad Sci U S A 2008 Nov 4;105(44):17187-92

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Variations in DNA elucidate molecular networks that cause disease

Chen Y., Zhu J., Lum P.Y., Yang X., Pinto S., MacNeil D.J., Zhang C., Lamb J., Edwards S., Sieberts S.K., Leonardson A., Castellini L.W., Wang S., Champy M.F., Zhang B., Emilsson V., Doss S., Ghazalpour A., Horvath S., Drake T.A., Lusis A.J., Schadt E.E.
Nature 2008 Mar 27;452(7186):429-35

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2007


Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine

Welter M., Vallone D., Samad T.A., Meziane H., Usiello A., Borrelli E.
Proc Natl Acad Sci U S A 2007 Apr 17;104(16):6840-5

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Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure

Dali-Youcef N., Mataki C., Coste A., Messaddeq N., Giroud S., Blanc S., Koehl C., Champy M.F., Chambon P., Fajas L., Metzger D., Schoonjans K., Auwerx J.
Proc Natl Acad Sci U S A 2007 Jun 19;104(25):10703-10708

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Animal models of anxiety in mice.

Bourin M, Petit-Demoulière B, Dhonnchadha BN, Hascöet M.
Fundam Clin Pharmacol 2007 Dec;21(6):567-74

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Bone Formation Mediated by Synergy-Acting Growth Factors Embedded in a Polyelectrolyte Multilayer Film

Dierich A., Le Guen E., Messaddeq N., Stoltz J.F., Netter P., Schaaf P., Voegel J.C., Benkirane-Jessel N.
Advanced Material 2007 ;19(5):693-97

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Estrous cycle effects on behavior of C57BL/6J and BALB/cByJ female mice: implications for phenotyping strategies

Meziane H., Ouagazzal A.M., Aubert L., Wietrzych M., Krezel W.
Genes Brain Behav 2007 Mar;6(2):192-200

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Evaluation of glucose homeostasis

Heikkinen S, Argmann CA, Champy MF, Auwerx J
Current Protocols In Molecular Biology 2007 January, 2007;Chapter 29():Unit 29B.3

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Histopathology in mouse metabolic investigations

Mark M., Teletin M., Antal C., Wendling O., Auwerx J., Heikkinen S., Khetchoumian K., Argmann C.A., Dgheem M.
Curr Protoc Mol Biol 2007 Apr;Chapter 29():Unit 29B 4

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IL-13 induces expression of CD36 in human monocytes through PPARgamma activation

Berry A., Balard P., Coste A., Olagnier D., Lagane C., Authier H., Benoit-Vical F., Lepert J.C., Seguela J.P., Magnaval J.F., Chambon P., Metzger D., Desvergne B., Wahli W., Auwerx J., Pipy B.
Eur J Immunol 2007 Apr 25;37(6):1642-1652

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In Vivo Imaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile Acid Signaling Tissue

Houten S.M., Volle D.H., Cummins C.L., Mangelsdorf D.J., Auwerx J.
Mol Endocrinol 2007 Jun;21(6):1312-1323

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Increased peripheral lipid clearance in an animal model of amyotrophic lateral sclerosis.

Fergani A, Oudart H, Gonzalez De Aguilar JL, Fricker B, René F, Hocquette JF, Meininger V, Dupuis L, Loeffler JP.
J Lipid Res 2007 Jul;48(7):1571-80

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LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

Coste A., Dubuquoy L., Barnouin R., Annicotte J.S., Magnier B., Notti M., Corazza N., Antal M.C., Metzger D., Desreumaux P., Brunner T., Auwerx J., Schoonjans K.
Proc Natl Acad Sci U S A 2007 Aug 7;104(32):13098-103

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LRP1 Functions as an Atheroprotective Integrator of TGFbeta and PDFG Signals in the Vascular Wall: Implications for Marfan Syndrome

Boucher P., Li W.P., Matz R.L., Takayama Y., Auwerx J., Anderson R.G., Herz J.
Plos One 2007 ;2():e448

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Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes

Indra A.K., Castaneda E., Antal M.C., Jiang M., Messaddeq N., Meng X., Loehr C.V., Gariglio P., Kato S., Wahli W., Desvergne B., Metzger D., Chambon P.
J Invest Dermatol 2007 May;127(5):1250-60

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Peroxisome Proliferator-Activated Receptor-{alpha} Activation Inhibits Langerhans Cell Function

Dubrac S., Stoitzner P., Pirkebner D., Elentner A., Schoonjans K., Auwerx J., Saeland S., Hengster P., Fritsch P., Romani N., Schmuth M.
J Immunol 2007 Apr 1;178(7):4362-72

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Quantitative ultrasonic tissue characterization as a new tool for continuous monitoring of chronic liver remodelling in mice

Guimond A., Teletin M., Garo E., D'Sa A., Selloum M., Champy M.F., Vonesch J.L., Monassier L.
Liver Int 2007 Aug;27(6):854-64

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Studies of the Common DIO2 Thr92Ala Polymorphism and Metabolic Phenotypes in 7342 Danish White Subjects

Grarup N., Andersen M.K., Andreasen C.H., Albrechtsen A., Borch-Johnsen K., Jorgensen T., Auwerx J., Schmitz O., Hansen T., Pedersen O.
J Clin Endocrinol Metab 2007 Jan;92(1):363-6

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Systematic gene expression mapping clusters nuclear receptors according to their function in the brain

Gofflot F., Chartoire N., Vasseur L., Heikkinen S., Dembele D., Le Merrer J., Auwerx J.
Cell 2007 Oct 19;131(2):405-18

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Temporal parameters of one-trial tolerance to benzodiazepines in four-plate test-retest.

Petit-Demouliere B, Bourin M.
Behav Brain Res 2007 Nov 2;183(2):222-5

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The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

Volle D.H., Duggavathi R., Magnier B.C., Houten S.M., Cummins C.L., Lobaccaro J.M., Verhoeven G., Schoonjans K., Auwerx J.
Genes Dev 2007 Feb 1;21(3):303-15

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Tissue collection for systematic phenotyping in the mouse

Antal C., Teletin M., Wendling O., Dgheem M., Auwerx J., Mark M.
Curr Protoc Mol Biol 2007 Oct;Chapter 29():Unit 29A 4

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[Functional genomics of the mouse: the European dynamics].

Masson R, Sorg T, Warot X.
Med Sci (Paris) 2007 Oct;23(10):877-9

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2006


A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development

Cobb J., Dierich A., Huss-Garcia Y., Duboule D.
Proc Natl Acad Sci U S A 2006 Mar 21;103(12):4511-5

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Absence of the steroid receptor coactivator-3 induces B-cell lymphoma

Coste A., Antal M.C., Chan S., Kastner P., Mark M., O'Malley B.W., Auwerx J.
Embo J 2006 Jun 7;25(11):2453-64

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ACE inhibition prevents myocardial infarction-induced skeletal muscle mitochondrial dysfunction.

Zoll J, Monassier L, Garnier A, N'Guessan B, Mettauer B, Veksler V, Piquard F, Ventura-Clapier R, Geny B.
J Appl Physiol 2006 Aug;101(2):385-91

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Apoptosis and differentiation commitment: novel insights revealed by gene profiling studies in mouse embryonic stem cells

Duval D., Trouillas M., Thibault C., Dembele D., Diemunsch F., Reinhardt B., Mertz A.L., Dierich A., Boeuf H.
Cell Death Differ 2006 Apr;13(4):564-75

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Auditory and visual prepulse inhibition in mice: parametric analysis and strain comparisons

Aubert L., Reiss D., Ouagazzal A.M.
Genes Brain Behav 2006 Jul;5(5):423-31

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Brg1 is required for murine neural stem cell maintenance and gliogenesis

Matsumoto S., Banine F., Struve J., Xing R., Adams C., Liu Y., Metzger D., Chambon P., Rao M.S., Sherman L.S.
Dev Biol 2006 Jan 15;289(2):372-83

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Cardiovascular disorders: insights into in vivo cardiovascular phenotyping

Monassier L, Constantinesco A
Standards Of Mouse Model Phenotyping 2006 ;Chapter 7. ():

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Collection of Blood and Plasma from the Mouse

Argmann CA, Auwerx J
2006 August, 2006

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Conditional (loxP-flanked) allele for the gene encoding the retinoic acid-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2)

Vermot J., Garnier J.M., Dierich A., Niederreither K., Harvey R.P., Chambon P., Dolle P.
Genesis 2006 Mar;44(3):155-8

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Deletion of peroxisome proliferator-activated receptor-alpha induces an alteration of cardiac functions

Loichot C., Jesel L., Tesse A., Tabernero A., Schoonjans K., Roul G., Carpusca I., Auwerx J., Andriantsitohaina R.
Am J Physiol Heart Circ Physiol 2006 Jul;291(1):H161-6

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Dissociation of analgesic and hormonal responses to forced swim stress using opioid receptor knockout mice

Contet C., Gaveriaux-Ruff C., Matifas A., Caradec C., Champy M.F., Kieffer B.L.
Neuropsychopharmacology 2006 Aug;31(8):1733-44

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Dynamic expression of retinoic acid-synthesizing and -metabolizing enzymes in the developing mouse inner ear

Romand R., Kondo T., Fraulob V., Petkovich M., Dolle P., Hashino E.
J Comp Neurol 2006 Jun 10;496(5):643-54

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Endocrine functions of bile acids

Houten S.M., Watanabe M., Auwerx J.
Embo J 2006 Apr 5;25(7):1419-25

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Evaluation of Energy Homeostasis

Argmann CA, Champy MF, Auwerx J
Current Protocols In Molecular Biology 2006 February, 2006;Chapter 29(Unit 29B.1):

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Exploration of metabolic and endocrine function in the mouse

Champy MF, Argmann CA, Chambon P, Auwerx J
Standards Of Mouse Model Phenotyping 2006

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Expression analysis of murine genes using in situ hybridization with radioactive and nonradioactively labeled RNA probes

Chotteau-Lelievre A., Dolle P., Gofflot F.
Methods Mol Biol 2006 ;326():61-87

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Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis.

Mark M(1), Ghyselinck NB, Chambon P.
Annu Rev Pharmacol Toxicol 2006 ;46():451-80

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Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes

Calleja C., Messaddeq N., Chapellier B., Yang H., Krezel W., Li M., Metzger D., Mascrez B., Ohta K., Kagechika H., Endo Y., Mark M., Ghyselinck N.B., Chambon P.
Genes Dev 2006 Jun 1;20(11):1525-38

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Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo

Scherrer G., Tryoen-Toth P., Filliol D., Matifas A., Laustriat D., Cao Y.Q., Basbaum A.I., Dierich A., Vonesh J.L., Gaveriaux-Ruff C., Kieffer B.L.
Proc Natl Acad Sci U S A 2006 Jun 20;103(25):9691-6

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Lipid and Bile Acid Analysis

Argmann CA, Houten SM, Champy MF, Auwerx j
Current Protocols In Molecular Biology 2006 August, 2006

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Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis

Stratis A., Pasparakis M., Markur D., Knaup R., Pofahl R., Metzger D., Chambon P., Krieg T., Haase I.
J Invest Dermatol 2006 Mar;126(3):614-20

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Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62

Rodriguez A., Duran A., Selloum M., Champy M.F., Diez-Guerra F.J., Flores J.M., Serrano M., Auwerx J., Diaz-Meco M.T., Moscat J.
Cell Metab 2006 Mar;3(3):211-22

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Mice models of hypertension

Monassier L, Combe R, El Fertak L
Drug Discovery Today: Disease Models 2006 ;3(3):273-281

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Minimizing Variation Due to Genotype and Environment

Argmann CA, Auwerx J
Current Protocols In Molecular Biology 2006 February, 2006;29A.2.1-29A.2.3():

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Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program

Louet J.F., Coste A., Amazit L., Tannour-Louet M., Wu R.C., Tsai S.Y., Tsai M.J., Auwerx J., O'Malley B.W.
Proc Natl Acad Sci U S A 2006 Nov 21;103(47):17868-73

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PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes

Schuler M., Ali F., Chambon C., Duteil D., Bornert J.M., Tardivel A., Desvergne B., Wahli W., Chambon P., Metzger D.
Cell Metab 2006 Nov;4(5):407-14

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Receptor protein tyrosine phosphatase gamma is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development

Lamprianou S., Vacaresse N., Suzuki Y., Meziane H., Buxbaum J.D., Schlessinger J., Harroch S.
Mol Cell Biol 2006 Jul;26(13):5106-19

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., Auwerx J.
Cell 2006 Dec 15;127(6):1109-22

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Retinoic Acid Metabolism and Signaling Pathways in the Adult and Developing Mouse Testis

Vernet N., Dennefeld C., Rochette-Egly C., Oulad-Abdelghani M., Chambon P., Ghyselinck N.B., Mark M.
Endocrinology 2006 Jan;147(1):96-110

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Retinoid signaling in inner ear development

Romand R., Dolle P., Hashino E.
J Neurobiol 2006 May 10;66(7):687-704

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Retinoids and spermatogenesis: Lessons from mutant mice lacking the plasma retinol binding protein

Ghyselinck N.B., Vernet N., Dennefeld C., Giese N., Nau H., Chambon P., Viville S., Mark M.
Dev Dyn 2006 Apr 3;235(6):1608-1622

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Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death.

Andrieu D, Meziane H, Marly F, Angelats C, Fernandez PA, Muscatelli F.
Bmc Dev Biol 2006 Nov 20;6():56

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Skin epidermis lacking the c-myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene

Oskarsson T., Essers M.A., Dubois N., Offner S., Dubey C., Roger C., Metzger D., Chambon P., Hummler E., Beard P., Trumpp A.
Genes Dev 2006 Aug 1;20(15):2024-9

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Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling

Nenci A., Huth M., Funteh A., Schmidt-Supprian M., Bloch W., Metzger D., Chambon P., Rajewsky K., Krieg T., Haase I., Pasparakis M.
Hum Mol Genet 2006 Feb 15;15(4):531-42

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Temporal regulation of Cre recombinase activity in neural stem cells

Imayoshi I., Ohtsuka T., Metzger D., Chambon P., Kageyama R.
Genesis 2006 May;44(5):233-8

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Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis

Li M., Hener P., Zhang Z., Kato S., Metzger D., Chambon P.
Proc Natl Acad Sci U S A 2006 Aug 1;103(31):11736-41

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Uses of Forward and Reverse Genetics in Mice to Study Gene Function

Argmann CA, Dierich A, Auwerx J
2006 February, 2006

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Viral-mediated temporally controlled dopamine production in a rat model of Parkinson disease

Li X.G., Okada T., Kodera M., Nara Y., Takino N., Muramatsu C., Ikeguchi K., Urano F., Ichinose H., Metzger D., Chambon P., Nakano I., Ozawa K., Muramatsu S.
Mol Ther 2006 Jan;13(1):160-6

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Visceral obesity is associated with high levels of serum squalene

Peltola P., Pihlajamaki J., Koutnikova H., Ruotsalainen E., Salmenniemi U., Vauhkonen I., Kainulainen S., Gylling H., Miettinen T.A., Auwerx J., Laakso M.
Obesity (Silver Spring) 2006 Jul;14(7):1155-63

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2005


Assessment of left ventricular perfusion, volumes, and motion in mice using pinhole gated SPECT.

Constantinesco A, Choquet P, Monassier L, Israel-Jost V, Mertz L.
J Nucl Med 2005 Jun;46(6):1005-11

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Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development

Matt N., Schmidt C.K., Dupe V., Dennefeld C., Nau H., Chambon P., Mark M., Ghyselinck N.B.
Dev Dyn 2005 Mar 11;233(1):167-176

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Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice

Martin M., Gallego-Llamas J., Ribes V., Kedinger M., Niederreither K., Chambon P., Dolle P., Gradwohl G.
Dev Biol 2005 Aug 15;284(2):399-411

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EMPReSS: standardized phenotype screens for functional annotation of the mouse genome.

Brown SD, Chambon P, de Angelis MH; Eumorphia Consortium.
Nat Genet 2005 Nov;37(11):1155

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Functional role of RXRs and PPARgamma in mature adipocytes

Metzger D., Imai T., Jiang M., Takukawa R., Desvergne B., Wahli W., Chambon P.
Prostaglandins Leukot Essent Fatty Acids 2005 Jul;73(1):51-8

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Genomewide production of multipurpose alleles for the functional analysis of the mouse genome

Schnutgen F., De-Zolt S., Van Sloun P., Hollatz M., Hansen J., Altschmied J., Seisenberger C., Ghyselinck N.B., Ruiz P., Chambon P., Wurst W., von Melchner H.
Proc Natl Acad Sci U S A 2005 May 17;102(20):7221-6

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Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection

Dharancy S., Malapel M., Perlemuter G., Roskams T., Cheng Y., Dubuquoy L., Podevin P., Conti F., Canva V., Philippe D., Gambiez L., Mathurin P., Paris J.C., Schoonjans K., Calmus Y., Pol S., Auwerx J., Desreumaux P.
Gastroenterology 2005 Feb;128(2):334-42

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Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation

Schoonjans K., Dubuquoy L., Mebis J., Fayard E., Wendling O., Haby C., Geboes K., Auwerx J.
Proc Natl Acad Sci U S A 2005 Feb 8;102(6):2058-62

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Mouse phenogenomics: the fast track to "systems metabolism"

Argmann C.A., Chambon P., Auwerx J.
Cell Metab 2005 Dec;2(6):349-60

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Peroxisome proliferator-activated receptor gamma: the more the merrier?

Argmann C.A., Cock T.A., Auwerx J.
Eur J Clin Invest 2005 Feb;35(2):82-92

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Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells

Matt N., Dupe V., Garnier J.M., Dennefeld C., Chambon P., Mark M., Ghyselinck N.B.
Development 2005 Nov;132(21):4789-800

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TAF10 is required for the establishment of skin barrier function in foetal, but not in adult mouse epidermis

Indra A.K., Mohan W.S., Frontini M., Scheer E., Messaddeq N., Metzger D., Tora L.
Dev Biol 2005 Sep 1;285(1):28-37

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Targeted somatic mutagenesis in the mouse epidermis

Metzger D., Li M., Chambon P.
Methods Mol Biol 2005 ;289():329-40

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Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse

Schuler M., Ali F., Metzger E., Chambon P., Metzger D.
Genesis 2005 Apr;41(4):165-70

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The optomotor response: a robust first-line visual screening method for mice.

Abdeljalil J, Hamid M, Abdel-Mouttalib O, Stéphane R, Raymond R, Johan A, José S, Pierre C, Serge P.
Vision Res 2005 May;45(11):1439-46

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Working memory deficits in retinoid X receptor gamma-deficient mice

Wietrzych M., Meziane H., Sutter A., Ghyselinck N., Chapman P.F., Chambon P., Krezel W.
Learn Mem 2005 May-Jun;12(3):318-26

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2004


Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Um S.H., Frigerio F., Watanabe M., Picard F., Joaquin M., Sticker M., Fumagalli S., Allegrini P.R., Kozma S.C., Auwerx J., Thomas G.
Nature 2004 Sep 9;431(7005):200-5

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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

Watanabe M., Houten S.M., Wang L., Moschetta A., Mangelsdorf D.J., Heyman R.A., Moore D.D., Auwerx J.
J Clin Invest 2004 May;113(10):1408-18

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Cardiovascular and survival effects of sympatho-inhibitors in adriamycin-induced cardiomyopathy in rats.

Thomas L, Bellmont S, Christen MO, La Roche B, Monassier L.
Fundam Clin Pharmacol 2004 Dec;18(6):649-55

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Cre-mediated conditional gene targeting to understand liver functions

Metzger D., Chambon P
Drug Discovery Today: Disease Models 2004 ;1(3):229-234

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Current mouse models for studying cardiac dysfunctions: technical and imaging aspects

Monassier L, Theodoropoulos C, Sandler R, Constantinesco A.
Drug Discovery Today 2004 ;1():235-241

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Disease progression despite early loss of polyglutamine protein expression in SCA7 mouse model

Helmlinger D., Abou-Sleymane G., Yvert G., Rousseau S., Weber C., Trottier Y., Mandel J.L., Devys D.
J Neurosci 2004 Feb 25;24(8):1881-7

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Efficient temporally controlled targeted somatic mutagenesis in hepatocytes of the mouse

Schuler M., Dierich A., Chambon P., Metzger D.
Genesis 2004 Jul;39(3):167-72

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Expression of the liver X receptor alpha and beta in embryonic and adult mice

Annicotte J.S., Schoonjans K., Auwerx J.
Anat Rec 2004 Apr;277A(2):312-6

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Idebenone delays the onset of cardiac functional alteration without correction of Fe-S enzymes deficit in a mouse model for Friedreich ataxia

Seznec H., Simon D., Monassier L., Criqui-Filipe P., Gansmuller A., Rustin P., Koenig M., Puccio H.
Hum Mol Genet 2004 May 15;13(10):1017-24

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Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice

Fajas L., Annicotte J.S., Miard S., Sarruf D., Watanabe M., Auwerx J.
J Clin Invest 2004 May;113(9):1288-95

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Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts

Jaffre F., Callebert J., Sarre A., Etienne N., Nebigil C.G., Launay J.M., Maroteaux L., Monassier L.
Circulation 2004 Aug 24;110(8):969-74

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Knockout mouse models in pain research

Dierich A., Kieffer B.L.
Methods Mol Med 2004 ;99():269-300

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Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells

Mascrez B., Ghyselinck N.B., Watanabe M., Annicotte J.S., Chambon P., Auwerx J., Mark M.
Embo Rep 2004 Mar;5(3):285-290

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LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis

Fayard E., Auwerx J., Schoonjans K.
Trends Cell Biol 2004 May;14(5):250-60

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Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene

Yan K.P., Dolle P., Mark M., Lerouge T., Wendling O., Chambon P., Losson R.
Gene 2004 Jun 9;334():3-13

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Mouse functional genomics requires standardization of mouse handling and housing conditions

Champy M.F., Selloum M., Piard L., Zeitler V., Caradec C., Chambon P., Auwerx J.
Mamm Genome 2004 Oct;15(10):768-83

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Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction

Mark M., Yoshida-Komiya H., Gehin M., Liao L., Tsai M.J., O'Malley B.W., Chambon P., Xu J.
Proc Natl Acad Sci U S A 2004 Mar 30;101(13):4453-8

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Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse.

Imai T, Takakuwa R, Marchand S, Dentz E, Bornert JM, Messaddeq N, Wendling O, Mark M, Desvergne B, Wahli W, Chambon P, Metzger D.
Proc Natl Acad Sci U S A 2004 Mar 30;101(13):4543-7

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Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm

Cock T.A., Houten S.M., Auwerx J.
Embo Rep 2004 Feb;5(2):142-7

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PU.1 determines the self-renewal capacity of erythroid progenitor cells

Back J., Dierich A., Bronn C., Kastner P., Chan S.
Blood 2004 May 15;103(10):3615-23

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Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium

Mori M., Metzger D., Picaud S., Hindelang C., Simonutti M., Sahel J., Chambon P., Mark M.
Am J Pathol 2004 Feb;164(2):701-10

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Retinoic acid signalling in the development of branchial arches

Mark M., Ghyselinck N.B., Chambon P.
Curr Opin Genet Dev 2004 Oct;14(5):591-8

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Synergy between LRH-1 and beta-Catenin Induces G(1) Cyclin-Mediated Cell Proliferation

Botrugno O.A., Fayard E., Annicotte J.S., Haby C., Brennan T., Wendling O., Tanaka T., Kodama T., Thomas W., Auwerx J., Schoonjans K.
Mol Cell 2004 Aug 27;15(4):499-509

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The European dimension for the mouse genome mutagenesis program

Auwerx J., Avner P., Baldock R., Ballabio A., Balling R., Barbacid M., Berns A., Bradley A., Brown S., Carmeliet P., Chambon P., Cox R., Davidson D., Davies K., Duboule D., Forejt J., Granucci F., Hastie N., De Angelis M.H., Jackson I., Kioussis D., Kollias G., Lathrop M., Lendahl U., Malumbres M., Von Melchner H., Muller W., Partanen J., Ricciardi-Castagnoli P., Rigby P., Rosen B., Rosenthal N., Skarnes B., Stewart A.F., Thornton J., Tocchini-Valentini G., Wagner E., Wahli W., Wurst W.
Nat Genet 2004 Sep;36(9):925-7

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Tissue-specific and inducible Cre-mediated recombination in the gut epithelium

El Marjou F., Janssen K.P., Hung-Junn Chang B., Li M., Hindie V., Chan L., Louvard D., Chambon P., Metzger D., Robine S.
Genesis 2004 Jul;39(3):186-93

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2003


A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse

Schnutgen F., Doerflinger N., Calleja C., Wendling O., Chambon P., Ghyselinck N.B.
Nat Biotechnol 2003 May;21(5):562-5

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A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment

Dupe V., Matt N., Garnier J.M., Chambon P., Mark M., Ghyselinck N.B.
Proc Natl Acad Sci U S A 2003 Nov 25;100(24):14036-14041

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Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR{gamma} hypomorphic mice

Koutnikova H., Cock T.A., Watanabe M., Houten S.M., Champy M.F., Dierich A., Auwerx J.
Proc Natl Acad Sci U S A 2003 Nov 25;100(24):14457-14462

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Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse

Menissier de Murcia J., Ricoul M., Tartier L., Niedergang C., Huber A., Dantzer F., Schreiber V., Ame J.C., Dierich A., LeMeur M., Sabatier L., Chambon P., de Murcia G.
Embo J 2003 May 1;22(9):2255-63

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I(1) imidazoline receptors involved in cardiovascular regulation: where are we and where are we going?

Bousquet P, Greney H, Bruban V, Schann S, Ehrhardt JD, Monassier L, Feldman J.
Ann N Y Acad Sci 2003 Dec;1009():228-33

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Knockout mice as model systems for studying nm23/NDP kinase gene functions. Application to the nm23-M1 gene

Arnaud-Dabernat S., Bourbon P.M., Dierich A., Le Meur M., Daniel J.Y.
J Bioenerg Biomembr 2003 Feb;35(1):19-30

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Leptin: cutting the fat off the bone

Cock T.A., Auwerx J.
Lancet 2003 Nov 8;362(9395):1572-4

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NSD1 is essential for early post-implantation development and has a catalytically active SET domain

Rayasam G.V., Wendling O., Angrand P.O., Mark M., Niederreither K., Song L., Lerouge T., Hager G.L., Chambon P., Losson R.
Embo J 2003 Jun 16;22(12):3153-3163

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Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy

Nebigil C.G., Jaffre F., Messaddeq N., Hickel P., Monassier L., Launay J.M., Maroteaux L.
Circulation 2003 Jul 1;107(25):3223-9

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Pancreatic-Duodenal Homeobox 1 Regulates Expression of Liver Receptor Homolog 1 during Pancreas Development

Annicotte J.S., Fayard E., Swift G.H., Selander L., Edlund H., Tanaka T., Kodama T., Schoonjans K., Auwerx J.
Mol Cell Biol 2003 Oct 1;23(19):6713-6724

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Récepteurs à la Provençale. EMBO workshop on the biology of nuclear receptors.

Auwerx J., Drouin J., Laudet V.
Embo Rep 2003 Nov 21;4(12):

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TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice

Mohan W.S., Scheer E., Wendling O., Metzger D., Tora L.
Mol Cell Biol 2003 Jun;23(12):4307-18

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2002


A conditional floxed (loxP-flanked) allele for the retinoic acid receptor beta (RARbeta) gene

Chapellier B., Mark M., Bastien J., Dierich A., LeMeur M., Chambon P., Ghyselinck N.B.
Genesis 2002 Feb;32(2):91-4

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A conditional floxed (loxP-flanked) allele for the retinoic acid receptor gamma (RARgamma) gene

Chapellier B., Mark M., Garnier J.M., Dierich A., Chambon P., Ghyselinck N.B.
Genesis 2002 Feb;32(2):95-8

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A Hoxa2 knockin allele that expresses EGFP upon conditional Cre- mediated recombination

Pasqualetti M., Ren S.Y., Poulet M., LeMeur M., Dierich A., Rijli F.M.
Genesis 2002 ;32(2):109-11.

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A Hoxa2 mutant conditional allele generated by Flp- and Cre-mediated recombination

Ren S.Y., Pasqualetti M., Dierich A., Le Meur M., Rijli F.M.
Genesis 2002 ;32(2):105-8.

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Evidence for synergy between alpha(2)-adrenergic and nonadrenergic mechanisms in central blood pressure regulation.

Bruban V, Estato V, Schann S, Ehrhardt JD, Monassier L, Renard P, Scalbert E, Feldman J, Bousquet P.
Circulation 2002 Mar 5;105(9):1116-21

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Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I

Schoonjans K., Annicotte J.S., Huby T., Botrugno O.A., Fayard E., Ueda Y., Chapman J., Auwerx J.
Embo Rep 2002 Dec;3(12):1181-7

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Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation

Picard F., Wanatabe M., Schoonjans K., Lydon J., O'Malley B.W., Auwerx J.
Proc Natl Acad Sci U S A 2002 ;99(24):15644-15648.

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Sigma receptors: from discovery to highlights of their implications in the cardiovascular system.

Monassier L, Bousquet P.
Fundam Clin Pharmacol 2002 Feb;16(1):1-8

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SRC-1 and TIF2 control energy balance between white and brown adipose tissues

Picard F., Gehin M., Annicotte J., Rocchi S., Champy M.F., O'Malley B.W., Chambon P., Auwerx J.
Cell 2002 Dec 27;111(7):931-41

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The AF-1 activation-function of ERalpha may be dispensable to mediate the effect of estradiol on endothelial NO production in mice

Pendaries C., Darblade B., Rochaix P., Krust A., Chambon P., Korach K.S., Bayard F., Arnal J.F.
Proc Natl Acad Sci U S A 2002 ;99(4):2205-10.

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The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP

Gehin M., Mark M., Dennefeld C., Dierich A., Gronemeyer H., Chambon P.
Mol Cell Biol 2002 ;22(16):5923-37.

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The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation

Fajas L., Egler V., Reiter R., Hansen J., Kristiansen K., Debril M.B., Miard S., Auwerx J.
Dev Cell 2002 Dec;3(6):903-10

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