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A resource of targeted mutant mouse lines for 5,061 genes.

Birling MC, Yoshiki A, Adams DJ, Ayabe S, Beaudet AL, Bottomley J, Bradley A, Brown SDM, Bürger A, Bushell W, Chiani F, Chin HG, Christou S, Codner GF, DeMayo FJ, Dickinson ME, Doe B, Donahue LR, Fray MD, Gambadoro A, Gao X, Gertsenstein M, Gomez-Segura A, Goodwin LO, Heaney JD, Hérault Y, de Angelis MH, Jiang ST, Justice MJ, Kasparek P, King RE, Kühn R, Lee H, Lee YJ, Liu Z, Lloyd KCK, Lorenzo I, Mallon AM, McKerlie C, Meehan TF, Fuentes VM, Newman S, Nutter LMJ, Oh GT, Pavlovic G, Ramirez-Solis R, Rosen B, Ryder EJ, Santos LA, Schick J, Seavitt JR, Sedlacek R, Seisenberger C, Seong JK, Skarnes WC, Sorg T, Steel KP, Tamura M, Tocchini-Valentini GP, Wang CL, Wardle-Jones H, Wattenhofer-Donzé M, Wells S, Wiles MV, Willis BJ, Wood JA, Wurst W, Xu Y, Teboul L, Murray SA
Nat Genet 2021 Apr;53(4):416-419

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Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society

Dierssen M.a,b,c · Herault Y.d · Helguera P.e · Martínez de Lagran M.a,c · Vazquez A.b · Christian B.f · Carmona-Iragui M.g,h · Wiseman F.i · Mobley W.j · Fisher E.M.C.k · Brault V.d · Esbensen A.l · Jacola L.M.m · Potier M.C.n · Hamlett E.D.o · Abbeduto L.p · del Hoyo Soriano L.p · Busciglio J.q · Iulita M.F.r · Crispino J.s · Malinge S.t · Barone E.u · Perluigi M.u · Costanzo F.v · Delabar J.M.n · Bartesaghi R.w · Dekker A.D.x · De Deyn P.x,y · Fortea Ormaechea J.g,h · Shaw P.A.z · Haydar T.F.z · Sherman S.L.A · Strydom A.B · Bhattacharyya A.f
Molecular Syndromology 2021 MAY 2021

Characterization of the spontaneous degenerative mitral valve disease in FVB mice.

Ayme-Dietrich E, Da Silva S, Bouabout GA, Arnoux A, Guyonnet J, Becker G, Monassier L
Plos One 2021 ;16(9):e0257022

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Droplet digital PCR or quantitative PCR for in-depth genomic and functional validation of genetically altered rodents.

Lindner L, Cayrou P, Rosahl TW, Zhou HH, Birling MC, Herault Y, Pavlovic G
Methods 2021 Jul;191():107-119

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High Resolution Episcopic Microscopy for Qualitative and Quantitative Data in Phenotyping Altered Embryos and Adult Mice Using the New "Histo3D" System.

Wendling O, Hentsch D, Jacobs H, Lemercier N, Taubert S, Pertuy F, Vonesch JL, Sorg T, Di Michele M, Le Cam L, Rosahl T, Carballo-Jane E, Liu M, Mu J, Mark M, Herault Y
Biomedicines 2021 Jul 1;9(7):

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INFRAFRONTIER quality principles in systemic phenotyping.

Ehlich H, Cater HL, Flenniken AM, Goncalves Da Cruz I, Mura AM, Ntafis V, Raess M, Selloum M, Stoeger C, Suchanova S, Vuolteenaho R, Brown SDM, Hérault Y, Hinttala R, Hrabě de Angelis M, Kollias G, Kontoyiannis DL, Malissen B, McKerlie C, Sedláček R, Wells SE, Zarubica A, Rozman J, Sorg T
Mamm Genome 2021 Jul 30

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Integrative approach to interpret DYRK1A variants, leading to a frequent neurodevelopmental disorder.

Courraud J, Chater-Diehl E, Durand B, Vincent M, Del Mar Muniz Moreno M, Boujelbene I, Drouot N, Genschik L, Schaefer E, Nizon M, Gerard B, Abramowicz M, Cogné B, Bronicki L, Burglen L, Barth M, Charles P, Colin E, Coubes C, David A, Delobel B, Demurger F, Passemard S, Denommé AS, Faivre L, Feger C, Fradin M, Francannet C, Genevieve D, Goldenberg A, Guerrot AM, Isidor B, Johannesen KM, Keren B, Kibæk M, Kuentz P, Mathieu-Dramard M, Demeer B, Metreau J, Steensbjerre Møller R, Moutton S, Pasquier L, Pilekær Sørensen K, Perrin L, Renaud M, Saugier P, Rio M, Svane J, Thevenon J, Tran Mau Them F, Tronhjem CE, Vitobello A, Layet V, Auvin S, Khachnaoui K, Birling MC, Drunat S, Bayat A, Dubourg C, El Chehadeh S, Fagerberg C, Mignot C, Guipponi M, Bienvenu T, Herault Y, Thompson J, Willems M, Mandel JL, Weksberg R, Piton A
Genet Med 2021 Aug 3

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Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity.

Wang XL, Kooijman S, Gao Y, Tzeplaeff L, Cosquer B, Milanova I, Wolff SEC, Korpel N, Champy MF, Petit-Demoulière B, Goncalves Da Cruz I, Sorg-Guss T, Rensen PCN, Cassel JC, Kalsbeek A, Boutillier AL, Yi CX
Mol Psychiatry 2021 May 28

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Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models.

Duchon A, Del Mar Muniz Moreno M, Martin Lorenzo S, Silva de Souza MP, Chevalier C, Nalesso V, Meziane H, Loureiro de Sousa P, Noblet V, Armspach JP, Brault V, Herault Y
Hum Mol Genet 2021 May 28;30(9):771-788

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Pathogenesis of Anorectal Malformations in Retinoic Acid Receptor Knockout Mice Studied by HREM.

Mark M, Teletin M, Wendling O, Vonesch JL, Féret B, Hérault Y, Ghyselinck NB
Biomedicines 2021 Jun 28;9(7):

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Reliable and robust droplet digital PCR (ddPCR) and RT-ddPCR protocols for mouse studies.

Lindner L, Cayrou P, Jacquot S, Birling MC, Herault Y, Pavlovic G
Methods 2021 Jul;191():95-106

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Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models.

Martin Lorenzo S, Nalesso V, Chevalier C, Birling MC, Herault Y
Mol Autism 2021 Jan 13;12(1):1

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