The metabolic exploration platform of ICS performs specific, on-demand experiments as well as comprehensive metabolic analyses with primary and secondary phenotypic screens to evaluate in vivo the energy balance in mouse. These screens are performed under either basal condition or energy challenges using standardized techniques for the detection of phenotype in energy metabolism, glucose homeostasis, intestinal function, bone metabolism and renal function. It provides users with the techniques and scientific support used to design experimental protocols as well as for the development of new techniques to investigate metabolism. The metabolic exploration platform of ICS has a large expertise in phenotyping mouse model for diabetes, obesity and atherosclerosis.
The metabolic analysis of the mice could be combined with clinical assessments, by performing biochemical analysis in blood, plasma, urine and tissues (i.e, lipid and cholesterol content, glycogen content...) and by performing autopsy of the animal at the end of phenotyping study with several tissue collections (i.e, histology, mRNA anlaysis, protein analysis...).