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Pathological models to test drugs or to reveal a cardiac phenotype in mutant mice.
| Model | Angiotensin II | DOCA Salt (+ uninephrectomy) | Isoproterenol | L NAME |
| Blood pressure | +37% | +18% | +10% | +17% |
| LV Mass | +17% | +50% | +68% | +23% |
| Description | Small decrease of myocardial relaxation | Aorta and pulmonary artery are thickened with narrowed lumina. Kidney show glomerulome phritis | Major Fibrosis. Hyperkinetic. No diastolic dysfunction. | No diastolic dysfunction. Fibrosis |
Azlet osmotic pumps (Charles River Laboratories, Châtillon-sur-chalaronne, France)
Number of animals: 9 mice/gender/genotype
Body weight limit: 25 grams
To induce cardiac hypertrophy and cardiac remodeling by chronic isoproterenol infusion in mice as a model to further investigate the effects of mutation and/or pharmacological interventions.
- non-invasive blood pressure equipment (BP-2000 Blood Pressure Analysis System (Visitech Systems)
- echocardiography equipment
- osmotic mini pumps for isoproterenol solution
Number of animals : 9 mice/gender/genotype/experimental group
